Abstract
Objective
To observe the therapeutic efficacy of Xiaopi-I(消痞I号) on functional dyspepsia and its effects on gastric emptying.
Methods
A total of 134 patients with functional dyspepsia were randomly assigned to 2 groups. The patients in the Xiaopi-I group (66 cases) and the Domperidone group (68 cases) were given Xiaopi-I granules and Domperidone 10 mg, 3 times a day, respectively. Another 20 healthy volunteers were chosen as the negative control group. The severity scores of the symptoms, as well as the gastric emptying, were detected before and after 4-week treatment by barium strip-trial meal.
Results
During therapy, 6 cases from the Xiaopi-I group and 8 cases from the Domperidone group were lost to follow, and 120 cases finally finished the study. Statistical differences were observed from both groups in terms of the symptoms of postprandial fullness early satiety, epigastric pain, and epigastric burning after 4-week treatment (P<0.01). The symptomatic severity scores of the Xiaopi-I group before and after the treatment were 7.48±1.64 and 2.16±1.26, respectively (P<0.01). Gastric emptying rates were also improved in the patients with delayed gastric emptying, and the effective rates were 91.3% and 75.8% in the Xiaopi-I and Domperidone groups, respectively. No obvious adverse effects were found from both groups.
Conclusion
Xiaopi-I was an effective and safe agent in the treatment of functional dyspepsia and was worth of further development in clinical.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Xiong LS, Chen MH, Chen HX, Xu AG, Wang WA, Hu PJ. A population-based epidemiologic study of irritable bowel syndrome in Guangdong province. Natl Med J Chin (Chin) 2004;84:278–281.
Pan GZ, Lu SC, Ke MY, Han SM, Guo HP, Fang XC. An epidemiologic study of irritable bowel syndrome in Beijing: a stratified randomized study by clustering sampling. Chin J Epidemiol (Chin) 2000;21:26–29.
Wei XQ, Chen MH, Wang JH, Hu PJ. The epidemiology of irritable bowel syndrome and functional constipation of Guangzhou residents. Chin J Intern Med (Chin) 2001;40:517–520.
Thompson WG. The road to Rome. Gastroenterology 2006;130:1552–1556.
Song ZQ, Ke MY, Wang ZF, Chen LB, Wang ZH, Fang XC, et al. Solid gastric emptying function in patients with functional dyspepsia fulfilling Rome III Criteria. Chin J Gastroenterol (Chin) 2008;13:528–532.
Zhu HX, Li Y. The study of Xiaopi No.I by taken apart on gastrointestinal motility. Med J Liaoning (Chin) 2008;22:237–238.
Wang ZH, Da SP, Gong NP, Wu LC, Zhao C, Jiang MD. Mosapride in treating functional dyspepsia: a multicenter, double blind study. Chin J New Drugs Clin Rem (Chin) 2009;19:363–366.
Zheng XY, ed. Guiding principle of clinical research on new drugs of traditional Chinese medicine. Beijing: China Medic-Pharmaceutical Sciences and Technology Publishing House; 2002:134–139.
Zhu JZ, Leng ER, Chen DF, Shi HT, Gui XY. A screening study of the kinetogenie effects of l5 Chinese herbal medicines on the gastrointestinal tract in rats. Acta Acad Med Mil Tertiae (Chin) 2000;22:436–438.
Ci XL, Wang BE, Guo CY, Chen L. The effect of magnolia bark on gastrointestinal electrical activity in normal and endotoxin-shock rat. Chin J Tradit Med Sci Tech (Chin) 1999;6:154–157.
Ye DJ, Zhang SC, eds. Science of processing Chinese materia medica. Beijing: People’s Medical Publishing House; 1998:736–738.
Li SD. The effect of domperidone on functional dyspepsia. Chin J Dig (Chin) 2003;23:220–222.
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Li, H., Yang, Zy. & Li, Y. The therapeutic effect of Xiaopi-I(消痞I号) on functional dyspepsia. Chin. J. Integr. Med. 19, 223–227 (2013). https://doi.org/10.1007/s11655-011-0951-4
Received:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s11655-011-0951-4