Abstract
Objective
To observe the clinical effect of Astragalus Injection (黄芪注射液, AI) and its immuno-regulatory action in treating chronic aplastic anemia (CAA).
Methods
Sixty patients with CAA were randomly assigned to two groups equally, both were treated with Stanozolol three times a day, 2 mg each time through oral intake, but AI was given additionally to the patients in the treated group once a day via intravenous dripping. All were treated for 15 days as one therapeutic course and the whole medication lasted for more than 4 months totally, with follow-up adopted. The clinical efficacy was estimated and the changes of T-lymphocyte subsets in peripheral blood as well as the serum levels of tumor necrosis factor-α (TNF-α) and interleukin-2 (IL-2) were observed.
Results
The total effective rate in the treated group was 83.3% (25/30), which was higher than that in the control group 66.7% (20/30), showing significant difference between them (P<0.05). Levels of hemoglobin, WBC, reticular cell and platelet were elevated in both groups after treatment, but the improvement was significantly better in the treated group than that in the control group with respect to the former three indexes (P<0.05). The level of CD4+ increased and that of CD8+ decreased significantly after treatment in the treated group (P<0.05), which showed significant difference as compared with those in the control group (P<0.05). Levels of serum TNF-α and IL-2 lowered after treatment in both groups, but significance only showed in the treated group (P<0.05). The degree of proliferation in bone marrow got raised significantly and the percentage of non-hemopoietic cells reduced significantly in the treated group after treatment, also showing significant difference to those in the control group (P<0.05).
Conclusion
AI could promote the recovery of hemopoietic function, which might be through improving T-lymphocyte subsets and reducing the release of negative regulatory factors such as TNF-α and IL-2 to alleviate the inhibition on hemopoietic function.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Zhang ZN, editor. Standard for diagnosis and treatment of blood disease. 2nd ed. Beijing: Science Press, 1998: 33–36.
Maciejewski JP, Hlbbs JR, Anderson S, et al. Bone marrow and peripheral blood lymphocyte phenotype in patients with bone marrow failure. Exp Hematol 1994;22:1102–1110.
Mentzel U, Vogt H, Rossol R, et al. Analysis of lymphocyte subsets in patients with aplastic anemia before and during immunosuppressive therapy. Ann Hematol 1993;66:127–129.
He H, Shao ZH, He GS, et al. Role of Th1 cell in the pathogenesis of aplastic anemia. Chin J Hematol 2002;23(11):547–577.
Shao ZH, Chen KQ, Chen GB, et al. Correlation between the serum levels of interleukin-2 and soluble interleukin-2 receptor and the response to immunosuppressive therapy in severe aplastic anemia patients. Chin J Hematol 1997;18(4):180–182.
Zhang T, Sun BZ, Feng Q, et al. A comparative study on the expressions of IL-4, IFN-gamma and TNF-alpha in BMMNC of acute and chronic aplastic anemia patients. Chin J Hematol 2000;21(10):530–532.
Selleri C, Sato T, Anderson S, et al. Interferon-gamma and tumor necrosis factor-alpha suppress both early and late stages of hematopoiesis and induce programmed cell death. J Cell Physiol 1995;165:538–546.
Xu SF, OU YX. Progress on study of immunological pathogenetic mechanism of aplastic anemia. Med J Natl Defend Forces Northwest China 2002;23(1):56–58.
Wang ZG, Zhou JH, editors. Progress on pharmacological and clinical study of Chinese materia medica (Vol. 1). Beijing: Chinese Publishing House of Science and Technology, 1992:254–261.
Liu XK, Yu ZK. Progress on study of constituents and pharmacologic activity of astragalus. Shanghai Med Pharm J 1995;16(2):23–28.
Hu JM. Effect of astragalus polysaccharides on progenitors of granular macrophage series in mice. Chin J Exp Clin Immunol 1997;9(6):53–55.
Author information
Authors and Affiliations
Corresponding author
Additional information
Supported by the Funds of Langfang Municipal Department of Science and Technology (No. 2005050245)
Rights and permissions
About this article
Cite this article
Wang, Ms., Li, J., Di, Hx. et al. Clinical study on effect of Astragalus Injection (黄芪注射液) and its immuno-regulation action in treating chronic aplastic anemia. Chin. J Integ. Med. 13, 98–102 (2007). https://doi.org/10.1007/s11655-007-0098-5
Received:
Issue Date:
DOI: https://doi.org/10.1007/s11655-007-0098-5