A Peculiar Cause of Anaphylaxis: No More steak?
- Susan E. WolverAffiliated withGeneral Internal Medicine, Virginia Commonwealth University Email author
- , Diane R. SunAffiliated withDivision of Rheumatology, Allergy and Immunology, Virginia Commonwealth University
- , Scott P. ComminsAffiliated withAsthma and Allergic Diseases Center, The University of Virginia
- , Lawrence B. SchwartzAffiliated withDivision of Rheumatology, Allergy and Immunology, Virginia Commonwealth University
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In recent years, a newly recognized allergic disease has been uncovered, and seemingly idiopathic causes of anaphylaxis now have an explanation. Individuals bitten by the lone star tick may develop IgE antibodies to the carbohydrate galactose-α-1,3-galactose (alpha-gal). Upon exposure of sensitized subjects to mammalian meat containing alpha-gal on glycoproteins or glycolipids, delayed anaphylaxis may ensue, often three to six hours after ingestion.1 Many of these individuals have negative allergy skin prick tests to meat, further obscuring the diagnosis. With the recent development of IgE alpha-gal tests, the clinical diagnosis can be confirmed in the laboratory.
KEY WORDSallergy anaphylaxis immunology tick meat
- A Peculiar Cause of Anaphylaxis: No More steak?
Journal of General Internal Medicine
Volume 28, Issue 2 , pp 322-325
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- 1. General Internal Medicine, Virginia Commonwealth University, PO BOX 980120, Richmond, VA, 23298-0102, USA
- 2. Division of Rheumatology, Allergy and Immunology, Virginia Commonwealth University, Richmond, VA, USA
- 3. Asthma and Allergic Diseases Center, The University of Virginia, Charlottesville, VA, USA