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High-Protein Diet Improves Postoperative Weight Gain After Massive Small-Bowel Resection

  • 2014 SSAT Poster Presentation
  • Published:
Journal of Gastrointestinal Surgery Aims and scope

Abstract

Introduction

Short bowel syndrome (SBS) is a morbid clinical condition that results from massive small-bowel resection (SBR). After SBR, there is a dramatic weight loss in the acute postoperative period. Our aim was to determine the impact of a high-protein diet (HPD) on weight gain and body composition in mice after SBR.

Methods

C57BL/6 mice underwent 50 % proximal SBR. Postoperatively, mice were randomly selected to receive standard rodent liquid diet (LD) (n = 6) or an isocaloric HPD (n = 9) for 28 days. Mice weights were recorded daily. Body composition analyses were obtained weekly. Student’s t test was used for statistical comparisons with p < 0.05 considered significant.

Results

Mice that were fed HPD after SBR returned to baseline weight on average at postoperative day (POD) 8 versus mice that were fed LD that returned to baseline weight on average at POD 22. Total fat mass and lean mass were significantly greater by POD 14 within the HPD group. Both groups of mice demonstrated normal structural adaptation.

Conclusion

HPD results in greater weight gain and improved body composition in mice after SBR. This finding may be clinically important for patients with SBS since improved weight gain may reduce the time needed for parenteral nutrition.

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Acknowledgments

This work was supported by T32 DK077653 (Diaz-Miron), P30DK52574—Morphology and Murine Models Cores of the Digestive Diseases Research Core Center of the Washington University School of Medicine, and the Children’s Surgical Sciences Research Institute of the St. Louis Children’s Hospital Foundation. Dr. Sun was also supported by a Research Fellowship Award through the Association for Academic Surgery Foundation.

Conflict of Interest

The authors have no conflict of interest or financial disclosures.

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Authors and Affiliations

  1. Division of Pediatric Surgery; St. Louis Children’s Hospital, Department of Surgery, Washington University School of Medicine, St. Louis, MO, 63110, USA

    Raphael C. Sun, Pamela M. Choi, Jose Diaz-Miron, Joshua Sommovilla, Jun Guo, Christopher R. Erwin & Brad W. Warner

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  1. Raphael C. Sun
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  2. Pamela M. Choi
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  3. Jose Diaz-Miron
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  5. Jun Guo
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  7. Brad W. Warner
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Corresponding author

Correspondence to Brad W. Warner.

Additional information

This paper was presented at the SSAT Poster Session at DDW in Chicago, IL, on May 6, 2014.

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Sun, R.C., Choi, P.M., Diaz-Miron, J. et al. High-Protein Diet Improves Postoperative Weight Gain After Massive Small-Bowel Resection. J Gastrointest Surg 19, 451–457 (2015). https://doi.org/10.1007/s11605-014-2715-x

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  • DOI: https://doi.org/10.1007/s11605-014-2715-x

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