Skip to main content
SpringerLink
Log in

RETRACTED ARTICLE: Does the Hepatic Branch of Vagus Mediate the Secretion of Glucagon-Like Peptide-1 During the Roux-en-Y Gastric Bypass Surgery?

  • Original Article
  • Published:
Journal of Gastrointestinal Surgery Aims and scope

This article was retracted on 16 November 2015

Abstract

Objectives

The purpose of this study is to investigate the impact of the hepatic branch of the vagus and Roux-en-Y gastric bypass (RYGB) on the level of fasting and postprandial serum glucagon-like peptide-1 (GLP-1) in type 2 diabetic mellitus rats.

Methods

Randomized block design, factorial experiment. Forty-five type 2 diabetic rats were divided into four groups: sham operation (S, n = 10) and sham operation with the hepatic branch of the vagotomy (SV, n = 11), Roux-en-Y gastric bypass (RYGB, n = 12) and RYGB without preservation of the vagus (RYGBV, n = 12). Levels of fasting and postprandial serum GLP-1 30 min after 50 % glucose solution (2 g/kg) by gavage were determined before surgery and postoperatively at 1, 4, and 8 weeks. Interactions between RYGB and the common hepatic branch were also assessed.

Results

Roux-en-Y gastric bypass surgery significantly increased the concentration of postprandial serum GLP-1 and maintained it at a higher level (P < 0.05). Preservation of vagus hepatic branch only increased the concentration of postprandial serum GLP-1 at the initial stage (P < 0.05), which gradually weakened over time (P > 0.05). Both RYGB and vagotomy of the hepatic branch had no influence on fasting serum GLP-1 (P > 0.05).

Conclusions

During RYGB surgery for the long-term treatment of T2DM, preservation of the hepatic branch of the vagus might have no impact on serum GLP-1 level.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3
Fig. 4
Fig. 5
Fig. 6
Fig. 7

Similar content being viewed by others

References

  1. Shah, M., Law, J. H., Micheletto, F., Sathananthan, M., Dalla Man, C., Cobelli, C. & Vella, A. (2014). Contribution of endogenous glucagon-like peptide 1 to glucose metabolism after Roux-en-Y gastric bypass. Diabetes, 63(2), 483-493.

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  2. Lips, M. A., Groot, G. H., Klinken, J. B., Aarts, E., Berends, F. J., Janssen, I. M., … & Pijl, H. (2013). Calorie Restriction is a Major Determinant of the Short‐Term Metabolic Effects of Gastric Bypass Surgery in Obese Type 2 Diabetic Patients. Clinical endocrinology.

  3. Hayes, M. R., Kanoski, S. E., De Jonghe, B. C., Leichner, T. M., Alhadeff, A. L., Fortin, S. M., … & Grill, H. J. (2011). The common hepatic branch of the vagus is not required to mediate the glycemic and food intake suppressive effects of glucagon-like-peptide-1. American Journal of Physiology-Regulatory, Integrative and Comparative Physiology, 301(5), R1479.

  4. Nishizawa, M., Nakabayashi, H., Uehara, K., Nakagawa, A., Uchida, K., & Koya, D. (2013). Intraportal GLP-1 stimulates insulin secretion predominantly through the hepatoportal-pancreatic vagal reflex pathways. American Journal of Physiology-Endocrinology and Metabolism, 305(3), E376-E387.

    Article  CAS  PubMed  Google Scholar 

  5. Shin, A. C., Zheng, H., & Berthoud, H. R. (2012). Vagal innervation of hepatic portal vein and liver is not necessary for Roux-en-Y gastric bypass surgery-induced hypophagia, weight loss, and hypermetabolism. Annals of surgery, 255(2), 294.

    Article  PubMed Central  PubMed  Google Scholar 

  6. Lam, T. K., Pocai, A., Gutierrez-Juarez, R., Obici, S., Bryan, J., Aguilar-Bryan, L., & Rossetti, L. (2005). Hypothalamic sensing of circulating fatty acids is required for glucose homeostasis. Nature medicine, 11(3), 320-327.

    Article  CAS  PubMed  Google Scholar 

  7. Pocai, A., Obici, S., Schwartz, G. J., & Rossetti, L. (2005). A brain-liver circuit regulates glucose homeostasis. Cell metabolism, 1(1), 53-61.

    Article  CAS  PubMed  Google Scholar 

  8. Hira, T., Mochida, T., Miyashita, K., & Hara, H. (2009). GLP-1 secretion is enhanced directly in the ileum but indirectly in the duodenum by a newly identified potent stimulator, zein hydrolysate, in rats. American Journal of Physiology-Gastrointestinal and Liver Physiology, 297(4), G663-G671.

    Article  CAS  PubMed  Google Scholar 

  9. Bueter, M., Löwenstein, C., Ashrafian, H., Hillebrand, J., Bloom, S. R., Olbers, T., & le Roux, C. W. (2010). Vagal sparing surgical technique but not stoma size affects body weight loss in rodent model of gastric bypass. Obesity surgery, 20(5), 616-622.

    Article  PubMed Central  PubMed  Google Scholar 

  10. Kumar, E. K., & Janardhana, G. R. (2011). Antidiabetic activity of alcoholic stem extracts of < i > Nervilia plicata</i > in streptozotocin-nicotinamide induced type 2 diabetic rats. Journal of ethnopharmacology, 133(2), 480-483.

    Article  PubMed  Google Scholar 

  11. Hansen, C. F., Bueter, M., Theis, N., Lutz, T., Paulsen, S., Dalbøge, L. S., & Jelsing, J. (2013). Hypertrophy dependent doubling of l-cells in roux-en-y gastric bypass operated rats. PloS one, 8(6), e65696.

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  12. Berthoud, H. R., Shin, A. C., & Zheng, H. (2011). Obesity surgery and gut–brain communication. Physiology & behavior, 105(1), 106-119.

    Article  CAS  Google Scholar 

  13. J Neff, K., OShea, D., & W le Roux, C. (2013). Glucagon like peptide-1 (GLP-1) dynamics following bariatric surgery: a signpost to a new frontier.Current diabetes reviews, 9(2), 93-101.

  14. Campos, G. M., Rabl, C., Peeva, S., Ciovica, R., Rao, M., Schwarz, J. M., & Mulligan, K. (2010). Improvement in peripheral glucose uptake after gastric bypass surgery is observed only after substantial weight loss has occurred and correlates with the magnitude of weight lost. Journal of Gastrointestinal Surgery, 14(1), 15-23.

    Article  PubMed Central  PubMed  Google Scholar 

  15. Yu, H., Zheng, X., & Zhang, Z. (2013). Mechanism of Roux-en-Y gastric bypass treatment for type 2 diabetes in rats. Journal of Gastrointestinal Surgery, 17(6), 1073-1083.

    Article  PubMed Central  PubMed  Google Scholar 

Download references

Acknowledgments

This work was supported by grants from the NSFC (National Nature Science Foundation of China) (No.81270969/H0729) and STCSM (Science and Technology Commission of Shanghai Municipality) (No.12ZR1454300). Nian-Cun Qiu, Miao-E Liu and Bin Wang had the original conception, designed and carried out the experimental work, wrote the article. Xin Song and Ying Jiang participated in the data analysis and interpretation. Juan Wang and Zi-Qun Gu participated in data collection and coordination of experiment. Cheng-Xiang Shan and Ming Qiu were involved in the revision of the article. All authors read and approved the final manuscript.

Author information

Authors and Affiliations

  1. Department of General Surgery, Changzheng Hospital, Second Military Medical University, Shanghai, 200003, China

    Nian-Cun Qiu, Bin Wang, Xin Song, Ying Jiang, Juan Wang, Zi-Qun Gu, Cheng-Xiang Shan & Ming Qiu

  2. Key Laboratory of Reproductive Genetics, Ministry of Education, Zhengjiang University, Zhengjiang, China

    Miao-E Liu

Authors
  1. Nian-Cun Qiu
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Miao-E Liu
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Bin Wang
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Xin Song
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Ying Jiang
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Juan Wang
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Zi-Qun Gu
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. Cheng-Xiang Shan
    View author publications

    You can also search for this author in PubMed Google Scholar

  9. Ming Qiu
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding authors

Correspondence to Cheng-Xiang Shan or Ming Qiu.

Additional information

Nian-Cun Qiu, Miao-E Liu, and Bing Wang were co-first authors and Cheng-xiang Shan and Ming Qiu were corresponding authors.

The Journal Editors have retracted the article “Does the hepatic branch of vagus mediate the secretion of glucagon-like pepetide-1 during the Roux-en-Y gastric bypass surgery”, by Nian-Cun Qiu, Miao-E Liu, Bin Wang, Xin Song, Ying Jiang, Juan Wang, Zi-Qun Gu, Cheng-Xiang Shan, and Ming Qiu, which was published in Journal of Gastrointestinal Surgery, Volume 18, No. 11, 2014 pp 1957-1964. This is due to considerable overlap with the article “ Impact of the hepatic branch of the vagus and Roux-en Y gastric bypass on the hypoglycemic effect and glucagon-like peptide-1 in rats with type 2 diabetes mellitus”, by Nian-Cun Qiu, Qin Zhang, Xin Song, Miao-E Liu, Xiao-Ke Li, Cheng-Xiang Shan, and Ming Qiu which was published in Journal of Surgical Research, Volume 191, Issue 1, 2014, pp 123-129.

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Qiu, NC., Liu, ME., Wang, B. et al. RETRACTED ARTICLE: Does the Hepatic Branch of Vagus Mediate the Secretion of Glucagon-Like Peptide-1 During the Roux-en-Y Gastric Bypass Surgery?. J Gastrointest Surg 18, 1957–1964 (2014). https://doi.org/10.1007/s11605-014-2632-z

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s11605-014-2632-z

Keywords

Search

Navigation