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Management of Electrothermal Injury of Common Bile Duct with a Degradable Biliary Stent: an Experimental Study in a Porcine Model

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Journal of Gastrointestinal Surgery Aims and scope

Abstract

Background

Electrothermal injury of common bile duct is a frequent type of biliary injury. A long-term postoperative course and biliary leakage after removing T-tube are associated with external drainage. A method was developed to repair the injury with a degradable biliary stent instead of T-tube insertion.

Methods

Pigs were divided into a stent repair (SR) group (n = 18), a T-tube repair (TR) group (n = 4), and a suturing repair (SUR) group (n = 4). An electrothermal injury model was made by electric coagulation. Pigs in the SR group were further divided into five subgroups according to the observation time (2 weeks and 1, 3, 6, and 18 months). Pigs in the TR group and SUR group were observed for 6 months. Cholangiography was repeated and bilirubin level was monitored. Pigs were reoperated for further evaluation at the end of observation.

Results

No biliary stricture, bile leakage, or bile duct necrosis occurred in the SR group. The stent could be detected in the first 2 months. No stent migration or stent-related obstruction was observed. Three pigs in the SUR group had biliary stricture with elevated bilirubin levels.

Conclusions

These results suggested that the developed method for repairing electrothermal injury of common bile duct is feasible and safe.

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Acknowledgments

The authors thank Professor Liqun Wang and the members of his research team at the Institute of Polymer Science at Zhejiang University for their work in manufacturing the stent. The research was supported by the National Natural Science Foundation of China (no. 81101152) and International Program of China (2012DFA30410).

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Authors and Affiliations

  1. Department of General Surgery, Sir Run Run Shaw Hospital, Zhejiang University, 3 East Qingchun Road, Hangzhou, 310016, People’s Republic of China

    YiFan Wang, YueLong Liang, WeiJia Wang, RenAn Jin & XiuJun Cai

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  1. YiFan Wang
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  2. YueLong Liang
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  3. WeiJia Wang
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  4. RenAn Jin
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  5. XiuJun Cai
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Corresponding author

Correspondence to XiuJun Cai.

Additional information

YiFan Wang and YueLong Liang contributed equally to this work.

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Wang, Y., Liang, Y., Wang, W. et al. Management of Electrothermal Injury of Common Bile Duct with a Degradable Biliary Stent: an Experimental Study in a Porcine Model. J Gastrointest Surg 17, 1760–1765 (2013). https://doi.org/10.1007/s11605-013-2316-0

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  • DOI: https://doi.org/10.1007/s11605-013-2316-0

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