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Barrett’s Esophagus: A Review of the Literature

  • Review Article
  • Published:
Journal of Gastrointestinal Surgery Aims and scope

Abstract

Barrett’s esophagus (BE) is the premalignant lesion of esophageal adenocarcinoma (EAC) defined as specialized intestinal metaplasia of the tubular esophagus that results from chronic gastroesophageal reflux. Which patients are at risk of having BE and which are at further risk of developing EAC has yet to be fully established. Many aspects of the management of BE have changed considerably in the past 5 years alone. The aim of this review is to define the critical elements necessary to effectively manage individuals with BE. The general prevalence of BE is estimated at 1.6–3% and follows a demographic distribution similar to EAC. Both short-segment (<3 cm) and long-segment (≥3 cm) BE confer a significant risk for EAC that is increased by the development of dysplasia. The treatment for flat high-grade dysplasia is endoscopic radiofrequency ablation therapy. The benefits of ablation for non-dysplastic BE and BE with low-grade dysplasia have yet to be validated. By understanding the intricacies of the development, screening, surveillance, and treatment of BE, new insights will be gained into the prevention and early detection of EAC that may ultimately lead to a reduction in morbidity and mortality in this patient population.

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References

  1. H. Pohl and H. G. Welch. (2005, Jan 19). The role of overdiagnosis and reclassification in the marked increase of esophageal adenocarcinoma incidence. J. Natl. Cancer Inst. 97(2), pp. 142–146. Available: http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med4&AN=15657344.

    Article  PubMed  Google Scholar 

  2. N. R. Barrett, "Chronic peptic ulcer of the oesophagus and 'oesophagitis'." Br. J. Surg., vol. 38, pp. 175–182, Oct, 1950.

    Article  PubMed  CAS  Google Scholar 

  3. J. Hayward, "The lower end of the oesophagus." Thorax, vol. 16, pp. 36–41, Mar, 1961.

    Article  PubMed  CAS  Google Scholar 

  4. K. K. Wang, R. E. Sampliner and Practice Parameters Committee of the American College of,Gastroenterology, “Updated guidelines 2008 for the diagnosis, surveillance and therapy of Barrett’s esophagus.” Am. J. Gastroenterol., vol. 103, pp. 788–797, Mar, 2008.

    Article  PubMed  Google Scholar 

  5. A. J. Cameron, A. R. Zinsmeister, D. J. Ballard and J. A. Carney, “Prevalence of columnar-lined (Barrett’s) esophagus. Comparison of population-based clinical and autopsy findings.” Gastroenterology, vol. 99, pp. 918–922, Oct, 1990.

    PubMed  CAS  Google Scholar 

  6. J. Ronkainen, P. Aro, T. Storskrubb, S. E. Johansson, T. Lind, E. Bolling-Sternevald, M. Vieth, M. Stolte, N. J. Talley and L. Agreus, “Prevalence of Barrett’s esophagus in the general population: an endoscopic study.” Gastroenterology, vol. 129, pp. 1825–1831, Dec, 2005.

    Article  PubMed  Google Scholar 

  7. X. Fan, N. Snyder. (2009, Mar). Prevalence of Barrett’s esophagus in patients with or without GERD symptoms: Role of race, age, and gender. Dig. Dis. Sci. 54(3), pp. 572–577. Available: http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=medl&AN=18654849.

    Article  PubMed  Google Scholar 

  8. M. A. Eloubeidi and D. Provenzale, “Clinical and demographic predictors of Barrett’s esophagus among patients with gastroesophageal reflux disease: a multivariable analysis in veterans.” J. Clin. Gastroenterol., vol. 33, pp. 306–309, Oct, 2001.

    Article  PubMed  CAS  Google Scholar 

  9. R. V. Lord, K. Wickramasinghe, J. J. Johansson, S. R. Demeester, J. Brabender and T. R. Demeester, “Cardiac mucosa in the remnant esophagus after esophagectomy is an acquired epithelium with Barrett’s-like features.” Surgery, vol. 136, pp. 633–640, Sep, 2004.

    Article  PubMed  Google Scholar 

  10. A. C. Ford, D. Forman, P. D. Reynolds, B. T. Cooper and P. Moayyedi, “Ethnicity, gender, and socioeconomic status as risk factors for esophagitis and Barrett’s esophagus.” Am. J. Epidemiol., vol. 162, pp. 454–460, Sep 1, 2005.

    Article  PubMed  Google Scholar 

  11. Z. R. Edelstein, D. C. Farrow, M. P. Bronner, S. N. Rosen and T. L. Vaughan, “Central adiposity and risk of Barrett’s esophagus.” Gastroenterology, vol. 133, pp. 403–411, Aug, 2007.

    Article  PubMed  Google Scholar 

  12. Z. R. Edelstein, M. P. Bronner, S. N. Rosen and T. L. Vaughan. (2009, Apr). Risk factors for Barrett's esophagus among patients with gastroesophageal reflux disease: A community clinic-based case-control study. Am. J. Gastroenterol. 104(4), pp. 834–842. Available: http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=medl&AN=19319131.

    Article  PubMed  Google Scholar 

  13. V. N. Shirvani, R. Ouatu-Lascar, B. S. Kaur, M. B. Omary and G. Triadafilopoulos, “Cyclooxygenase 2 expression in Barrett’s esophagus and adenocarcinoma: Ex vivo induction by bile salts and acid exposure.” Gastroenterology, vol. 118, pp. 487–496, Mar, 2000.

    Article  PubMed  CAS  Google Scholar 

  14. D. Das, A. P. Chilton and J. A. Jankowski, “Chemoprevention of oesophageal cancer and the AspECT trial,” Recent Results Cancer Res., vol. 181, pp. 161–169, 2009.

    Article  PubMed  CAS  Google Scholar 

  15. L. A. Anderson, S. J. Murphy, B. T. Johnston, R. G. Watson, H. R. Ferguson, K. B. Bamford, A. Ghazy, P. McCarron, J. McGuigan, J. V. Reynolds, H. Comber and L. J. Murray. (2008, Jun). Relationship between helicobacter pylori infection and gastric atrophy and the stages of the oesophageal inflammation, metaplasia, adenocarcinoma sequence: Results from the FINBAR case-control study. Gut 57(6), pp. 734–739. Available: http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=medl&AN=18025067.

    Article  PubMed  CAS  Google Scholar 

  16. F. Yousef, C. Cardwell, M. M. Cantwell, K. Galway, B. T. Johnston and L. Murray. (2008, Aug 1). The incidence of esophageal cancer and high-grade dysplasia in Barrett's esophagus: A systematic review and meta-analysis. Am. J. Epidemiol. 168(3), pp. 237–249. Available: http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=medl&AN=18550563.

    Article  PubMed  Google Scholar 

  17. P. Sharma, G. W. Falk, A. P. Weston, D. Reker, M. Johnston and R. E. Sampliner, “Dysplasia and cancer in a large multicenter cohort of patients with Barrett’s esophagus.” Clin. Gastroenterol. Hepatol., vol. 4, pp. 566–572, May, 2006.

    Article  PubMed  Google Scholar 

  18. Conio M. Blanchi S. Lapertosa G. Ferraris R. Sablich R. Marchi S. D’Onofrio V. Lacchin T. Iaquinto G. Missale G. Ravelli P. Cestari R. Benedetti G. Macrì G. Fiocca R. Munizzi F. Filiberti R, “Long-term endoscopic surveillance of patients with Barrett’s esophagus. Incidence of dysplasia and adenocarcinoma: a prospective study.” Am. J. Gastroenterol., vol. 98, pp. 1931–1939, Sep, 2003.

    Article  PubMed  Google Scholar 

  19. J. Theisen, H. J. Stein, H. J. Dittler, M. Feith, C. Moebius, W. K. Kauer, M. Werner and J. R. Siewert. (2002, Apr). Preoperative chemotherapy unmasks underlying Barrett’s mucosa in patients with adenocarcinoma of the distal esophagus. Surg. Endosc. 16(4), pp. 671–673. Available: http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med4&AN=11972212.

    Article  PubMed  CAS  Google Scholar 

  20. A. P. Weston, P. Sharma, S. Mathur, S. Banerjee, A. K. Jafri, R. Cherian, D. McGregor, R. S. Hassanein and M. Hall, “Risk stratification of Barrett’s esophagus: updated prospective multivariate analysis.” Am. J. Gastroenterol., vol. 99, pp. 1657–1666, Sep, 2004.

    Article  PubMed  Google Scholar 

  21. J. Martinek, M. Benes, P. Brandtl, T. Hucl, M. Vasicek, L. Voska, V. Lanska, V. Nosek and J. Spicak. (2008, Sep). Low incidence of adenocarcinoma and high-grade intraepithelial neoplasia in patients with Barrett's esophagus: A prospective cohort study. Endoscopy 40(9), pp. 711–716. Available: http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=medl&AN=18698534.

    Article  PubMed  CAS  Google Scholar 

  22. R. E. Rudolph, T. L. Vaughan, B. E. Storer, R. C. Haggitt, P. S. Rabinovitch, D. S. Levine and B. J. Reid, “Effect of segment length on risk for neoplastic progression in patients with Barrett esophagus.” Ann. Intern. Med., vol. 132, pp. 612–620, Apr 18, 2000.

    PubMed  CAS  Google Scholar 

  23. P. T. Chandrasoma, R. Der, P. Dalton, G. Kobayashi, Y. Ma, J. Peters and T. Demeester, “Distribution and significance of epithelial types in columnar-lined esophagus.” Am. J. Surg. Pathol., vol. 25, pp. 1188–1193, Sep, 2001.

    Article  PubMed  CAS  Google Scholar 

  24. P. T. Chandrasoma, R. Der, Y. Ma, P. Dalton and M. Taira, “Histology of the gastroesophageal junction: an autopsy study.” Am. J. Surg. Pathol., vol. 24, pp. 402–409, Mar, 2000.

    Article  PubMed  CAS  Google Scholar 

  25. K. Takubo, J. Aida, Y. Naomoto, M. Sawabe, T. Arai, H. Shiraishi, M. Matsuura, C. Ell, A. May, O. Pech, M. Stolte and M. Vieth. (2009, Jan). Cardiac rather than intestinal-type background in endoscopic resection specimens of minute Barrett adenocarcinoma. Hum. Pathol. 40(1), pp. 65–74. Available: http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=medl&AN=18755496.

    Article  PubMed  Google Scholar 

  26. W. Liu, H. Hahn, R. D. Odze and R. K. Goyal. (2009, Apr). Metaplastic esophageal columnar epithelium without goblet cells shows DNA content abnormalities similar to goblet cell-containing epithelium. Am. J. Gastroenterol. 104(4), pp. 816–824. Available: http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=medl&AN=19293780.

    Article  PubMed  CAS  Google Scholar 

  27. F. Paraf, J. F. Flejou, J. P. Pignon, F. Fekete and F. Potet, “Surgical pathology of adenocarcinoma arising in Barrett’s esophagus. Analysis of 67 cases.” Am. J. Surg. Pathol., vol. 19, pp. 183–191, Feb, 1995.

    Article  PubMed  CAS  Google Scholar 

  28. R. J. Schlemper, R. H. Riddell, Y. Kato, F. Borchard, H. S. Cooper, S. M. Dawsey, M. F. Dixon, C. M. Fenoglio-Preiser, J. F. Flejou, K. Geboes, T. Hattori, T. Hirota, M. Itabashi, M. Iwafuchi, A. Iwashita, Y. I. Kim, T. Kirchner, M. Klimpfinger, M. Koike, G. Y. Lauwers, K. J. Lewin, G. Oberhuber, F. Offner, A. B. Price, C. A. Rubio, M. Shimizu, T. Shimoda, P. Sipponen, E. Solcia, M. Stolte, H. Watanabe and H. Yamabe, “The Vienna classification of gastrointestinal epithelial neoplasia.” Gut, vol. 47, pp. 251–255, Aug, 2000.

    Article  PubMed  CAS  Google Scholar 

  29. P. J. de Jonge, M. van Blankenstein, C. W. Looman, M. K. Casparie, G. A. Meijer and E. J. Kuipers. (2010, Aug). Risk of malignant progression in patients with Barrett's oesophagus: A dutch nationwide cohort study. Gut 59(8), pp. 1030–1036. Available: http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=medl&AN=20639249.

    Article  PubMed  Google Scholar 

  30. W. L. Curvers, F. J. ten Kate, K. K. Krishnadath, M. Visser, B. Elzer, L. C. Baak, C. Bohmer, R. C. Mallant-Hent, A. van Oijen, A. H. Naber, P. Scholten, O. R. Busch, H. G. Blaauwgeers, G. A. Meijer and J. J. Bergman. (2010, Jul). Low-grade dysplasia in Barrett's esophagus: Overdiagnosed and underestimated. Am. J. Gastroenterol. 105(7), pp. 1523–1530, Available: http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=medl&AN=20461069.

    Article  PubMed  Google Scholar 

  31. P. Gatenby, J. Ramus, C. Caygill, N. Shepherd, M. Winslet and A. Watson. (2009, Jun). Routinely diagnosed low-grade dysplasia in Barrett's oesophagus: A population-based study of natural history. Histopathology 54(7), pp. 814–819. Available: http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=medl&AN=19635100.

    Article  PubMed  Google Scholar 

  32. G. S. Dulai, P. G. Shekelle, D. M. Jensen, B. M. Spiegel, J. Chen, D. Oh and K. L. Kahn, “Dysplasia and risk of further neoplastic progression in a regional Veterans Administration Barrett’s cohort.” Am. J. Gastroenterol., vol. 100, pp. 775–783, Apr, 2005.

    Article  PubMed  Google Scholar 

  33. M. Kerkhof, H. van Dekken, E. W. Steyerberg, G. A. Meijer, A. H. Mulder, A. de Bruine, A. Driessen, F. J. ten Kate, J. G. Kusters, E. J. Kuipers, P. D. Siersema and g. CYBAR study, “Grading of dysplasia in Barrett’s oesophagus: substantial interobserver variation between general and gastrointestinal pathologists.” Histopathology, vol. 50, pp. 920–927, Jun, 2007.

    Article  PubMed  CAS  Google Scholar 

  34. S. B. Edge, D. R. Byrd, C. C. Compton, A. G. Fritz, F. L. Greene and A. Tritti, Eds., AJCC Cancer Staging Manual. New York: Springer, 2009.

    Google Scholar 

  35. A. P. Barbour, M. Jones, I. Brown, D. C. Gotley, I. Martin, J. Thomas, A. Clouston and B. M. Smithers. (2010, Sep). Risk stratification for early esophageal adenocarcinoma: Analysis of lymphatic spread and prognostic factors. Ann. Surg. Oncol. 17(9), pp. 2494–2502. Available: http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=medl&AN=20349213.

    Article  PubMed  Google Scholar 

  36. P. Sharma, J. Dent, D. Armstrong, J. J. Bergman, L. Gossner, Y. Hoshihara, J. A. Jankowski, O. Junghard, L. Lundell, G. N. Tytgat and M. Vieth, “The development and validation of an endoscopic grading system for Barrett’s esophagus: the Prague C & M criteria.” Gastroenterology, vol. 131, pp. 1392–1399, Nov, 2006.

    Article  PubMed  Google Scholar 

  37. R. Harrison, I. Perry, W. Haddadin, S. McDonald, R. Bryan, K. Abrams, R. Sampliner, N. J. Talley, P. Moayyedi and J. A. Jankowski, “Detection of intestinal metaplasia in Barrett’s esophagus: an observational comparator study suggests the need for a minimum of eight biopsies.” Am. J. Gastroenterol., vol. 102, pp. 1154–1161, Jun, 2007.

    Article  PubMed  Google Scholar 

  38. B. J. Reid, P. L. Blount, Z. Feng and D. S. Levine, “Optimizing endoscopic biopsy detection of early cancers in Barrett’s high-grade dysplasia.” Am. J. Gastroenterol., vol. 95, pp. 3089–3096, Nov, 2000.

    Article  PubMed  CAS  Google Scholar 

  39. A. May, E. Gunter, F. Roth, L. Gossner, M. Stolte, M. Vieth and C. Ell, “Accuracy of staging in early oesophageal cancer using high resolution endoscopy and high resolution endosonography: a comparative, prospective, and blinded trial.” Gut, vol. 53, pp. 634–640, May, 2004.

    Article  PubMed  CAS  Google Scholar 

  40. S. Ngamruengphong, V. K. Sharma and A. Das, “Diagnostic yield of methylene blue chromoendoscopy for detecting specialized intestinal metaplasia and dysplasia in Barrett’s esophagus: a meta-analysis.” Gastrointest. Endosc., vol. 69, pp. 1021–1028, May, 2009.

    Article  PubMed  Google Scholar 

  41. H. C. Wolfsen, J. E. Crook, M. Krishna, S. R. Achem, K. R. Devault, E. P. Bouras, D. S. Loeb, M. E. Stark, T. A. Woodward, L. L. Hemminger, F. K. Cayer and M. B. Wallace. (2008, Jul). Prospective, controlled tandem endoscopy study of narrow band imaging for dysplasia detection in Barrett's esophagus. Gastroenterology 135(1), pp. 24–31. Available: http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=medl&AN=18442484.

    Article  PubMed  Google Scholar 

  42. W. L. Curvers, L. A. Herrero, M. B. Wallace, L. M. Wong Kee Song, K. Ragunath, H. C. Wolfsen, G. A. Prasad, K. K. Wang, V. Subramanian, B. L. Weusten, F. J. Ten Kate and J. J. Bergman. (2010, Oct). Endoscopic tri-modal imaging is more effective than standard endoscopy in identifying early-stage neoplasia in Barrett's esophagus. Gastroenterology 139(4), pp. 1106–1114. Available: http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=medl&AN=20600033.

    Article  PubMed  Google Scholar 

  43. J. M. Inadomi, R. Sampliner, J. Lagergren, D. Lieberman, A. M. Fendrick and N. Vakil, “Screening and surveillance for Barrett esophagus in high-risk groups: a cost-utility analysis.” Ann. Intern. Med., vol. 138, pp. 176–186, Feb 4, 2003.

    PubMed  Google Scholar 

  44. A. Chak, A. Faulx, C. Eng, W. Grady, M. Kinnard, H. Ochs-Balcom and G. Falk, “Gastroesophageal reflux symptoms in patients with adenocarcinoma of the esophagus or cardia.” Cancer, vol. 107, pp. 2160–2166, Nov 1, 2006.

    Article  PubMed  Google Scholar 

  45. M. Maffei and J. M. Dumonceau, “Transnasal esogastroduodenoscopy (EGD): comparison with conventional EGD and new applications,” Swiss Med. Wkly., vol. 138, pp. 658–664, Nov 15, 2008.

    PubMed  Google Scholar 

  46. B. A. Jobe, J. G. Hunter, E. Y. Chang, C. Y. Kim, G. M. Eisen, J. D. Robinson, B. S. Diggs, R. W. O’Rourke, A. E. Rader, P. Schipper, D. A. Sauer, J. H. Peters, D. A. Lieberman and C. D. Morris, “Office-based unsedated small-caliber endoscopy is equivalent to conventional sedated endoscopy in screening and surveillance for Barrett’s esophagus: a randomized and blinded comparison.” Am. J. Gastroenterol., vol. 101, pp. 2693–2703, Dec, 2006.

    Article  PubMed  Google Scholar 

  47. K. J. Roberts, E. Harper, D. Alderson and M. Hallissey. (2010, Apr). Long-term survival and cost analysis of an annual Barrett's surveillance programme. Eur. J. Gastroenterol. Hepatol. 22(4), pp. 399–403. Available: http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=medl&AN=19858726.

    Article  PubMed  Google Scholar 

  48. T. Bright, A. Schloithe, J. A. Bull, R. J. Fraser, P. Bampton and D. I. Watson. (2009, Nov). Outcome of endoscopy surveillance for Barrett's oesophagus. ANZ J. Surg. 79(11), pp. 812–816. Available: http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=medl&AN=20078532.

    Article  PubMed  Google Scholar 

  49. R. C. Fitzgerald, I. T. Saeed, D. Khoo, M. J. Farthing and W. R. Burnham, “Rigorous surveillance protocol increases detection of curable cancers associated with Barrett’s esophagus.” Dig. Dis. Sci., vol. 46, pp. 1892–1898, Sep, 2001.

    Article  PubMed  CAS  Google Scholar 

  50. M. F. Reed, G. Tolis Jr, B. H. Edil, J. S. Allan, D. M. Donahue, H. A. Gaissert, A. C. Moncure, J. C. Wain, C. D. Wright and D. J. Mathisen. (2005, discussion 1110–5; Apr). Surgical treatment of esophageal high-grade dysplasia. Ann. Thorac. Surg. 79(4), pp. 1110–1115. Available: http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med4&AN=15797034.

    Article  PubMed  Google Scholar 

  51. N. S. Buttar, K. K. Wang, T. J. Sebo, D. M. Riehle, K. K. Krishnadath, L. S. Lutzke, M. A. Anderson, T. M. Petterson and L. J. Burgart, “Extent of high-grade dysplasia in Barrett’s esophagus correlates with risk of adenocarcinoma.” Gastroenterology, vol. 120, pp. 1630–1639, Jun, 2001.

    Article  PubMed  CAS  Google Scholar 

  52. E. E. Tseng, T. T. Wu, C. J. Yeo and R. F. Heitmiller, “Barrett’s esophagus with high grade dysplasia: surgical results and long-term outcome--an update.” J. Gastrointest. Surg., vol. 7, pp. 164–170, discussion 170–1; Feb, 2003.

    Article  PubMed  Google Scholar 

  53. W. Zhu, H. D. Appelman, J. K. Greenson, S. R. Ramsburgh, M. B. Orringer, A. C. Chang and B. J. McKenna. (2009, Jul). A histologically defined subset of high-grade dysplasia in Barrett mucosa is predictive of associated carcinoma. Am. J. Clin. Pathol. 132(1), pp. 94–100. Available: http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=medl&AN=19864239.

    Article  PubMed  Google Scholar 

  54. L. C. Hillman, L. Chiragakis, B. Shadbolt, G. L. Kaye and A. C. Clarke. (2008, Feb 15). Effect of proton pump inhibitors on markers of risk for high-grade dysplasia and oesophageal cancer in Barrett's oesophagus. Aliment. Pharmacol. Ther. 27(4), pp. 321–326. Available: http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=medl&AN=18047565.

    Article  PubMed  CAS  Google Scholar 

  55. R. Ouatu-Lascar and G. Triadafilopoulos, “Complete elimination of reflux symptoms does not guarantee normalization of intraesophageal acid reflux in patients with Barrett’s esophagus.” Am. J. Gastroenterol., vol. 93, pp. 711–716, May, 1998.

    Article  PubMed  CAS  Google Scholar 

  56. R. W. Yeh, L. B. Gerson and G. Triadafilopoulos, “Efficacy of esomeprazole in controlling reflux symptoms, intraesophageal, and intragastric pH in patients with Barrett’s esophagus.” Dis. Esophagus, vol. 16, pp. 193–198, 2003.

    Article  PubMed  CAS  Google Scholar 

  57. R. C. Fitzgerald, R. Lascar and G. Triadafilopoulos, “Review article: Barrett’s oesophagus, dysplasia and pharmacologic acid suppression,” Aliment. Pharmacol. Ther., vol. 15, pp. 269–276, Mar, 2001.

    Article  PubMed  CAS  Google Scholar 

  58. J. D. Horwhat, D. Baroni, C. Maydonovitch, E. Osgard, E. Ormseth, E. Rueda-Pedraza, H. J. Lee, W. K. Hirota and R. K. Wong, “Normalization of intestinal metaplasia in the esophagus and esophagogastric junction: incidence and clinical data.” Am. J. Gastroenterol., vol. 102, pp. 497–506, Mar, 2007.

    Article  PubMed  Google Scholar 

  59. F. T. Peters, S. Ganesh, E. J. Kuipers, W. J. Sluiter, E. C. Klinkenberg-Knol, C. B. Lamers and J. H. Kleibeuker, “Endoscopic regression of Barrett’s oesophagus during omeprazole treatment; a randomised double blind study,” Gut, vol. 45, pp. 489–494, Oct, 1999.

    Article  PubMed  CAS  Google Scholar 

  60. D. M. Nguyen, H. B. El-Serag, L. Henderson, D. Stein, A. Bhattacharyya and R. E. Sampliner. (2009, Dec). Medication usage and the risk of neoplasia in patients with Barrett's esophagus. Clin. Gastroenterol. Hepatol. 7(12), pp. 1299–1304. Available: http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=medl&AN=19523538.

    Article  PubMed  Google Scholar 

  61. H. B. El-Serag, T. V. Aguirre, S. Davis, M. Kuebeler, A. Bhattacharyya and R. E. Sampliner, “Proton pump inhibitors are associated with reduced incidence of dysplasia in Barrett’s esophagus.” Am. J. Gastroenterol., vol. 99, pp. 1877–1883, Oct, 2004.

    Article  PubMed  CAS  Google Scholar 

  62. L. Monaco, A. Brillantino, F. Torelli, M. Schettino, G. Izzo, A. Cosenza and N. Di Martino, “Prevalence of bile reflux in gastroesophageal reflux disease patients not responsive to proton pump inhibitors.” World J. Gastroenterol., vol. 15, pp. 334–338, Jan 21, 2009.

    Article  PubMed  Google Scholar 

  63. C. B. Morgenthal, M. D. Shane, A. Stival, N. Gletsu, G. Milam, V. Swafford, J. G. Hunter and C. D. Smith, “The durability of laparoscopic Nissen fundoplication: 11-year outcomes.” J. Gastrointest. Surg., vol. 11, pp. 693–700, Jun, 2007.

    Article  PubMed  Google Scholar 

  64. S. E. Attwood, L. Lundell, J. G. Hatlebakk, S. Eklund, O. Junghard, J. P. Galmiche, C. Ell, R. Fiocca and T. Lind. (2008, discussion 1654–5; Oct). Medical or surgical management of GERD patients with Barrett's esophagus: The LOTUS trial 3-year experience. J. Gastrointest. Surg. 12(10), pp. 1646–1654. Available: http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=medl&AN=18709511.

    Article  PubMed  CAS  Google Scholar 

  65. A. Ortiz, L. F. Martinez de Haro, P. Parrilla, G. Morales, J. Molina, J. Bermejo, R. Liron and J. Aguilar, “Conservative treatment versus antireflux surgery in Barrett’s oesophagus: long-term results of a prospective study.” Br. J. Surg., vol. 83, pp. 274–278, Feb, 1996.

    Article  PubMed  CAS  Google Scholar 

  66. M. Rossi, M. Barreca, N. de Bortoli, C. Renzi, S. Santi, A. Gennai, M. Bellini, F. Costa, M. Conio and S. Marchi, “Efficacy of Nissen fundoplication versus medical therapy in the regression of low-grade dysplasia in patients with Barrett esophagus: a prospective study.” Ann. Surg., vol. 243, pp. 58–63, Jan, 2006.

    Article  PubMed  Google Scholar 

  67. D. Epstein, L. Bojke, M. J. Sculpher and g. REFLUX trial. 2009, BMJ 339 pp. b2576. Available: http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=medl&AN=19654097.

  68. E. Y. Chang, C. D. Morris, A. K. Seltman, R. W. O’Rourke, B. K. Chan, J. G. Hunter and B. A. Jobe, “The effect of antireflux surgery on esophageal carcinogenesis in patients with Barrett esophagus: a systematic review,” Ann. Surg., vol. 246, pp. 11–21, Jul, 2007.

    Article  PubMed  Google Scholar 

  69. J. Lagergren and P. Viklund, “Is esophageal adenocarcinoma occurring late after antireflux surgery due to persistent postoperative reflux?.” World J. Surg., vol. 31, pp. 465–469, Mar, 2007.

    Article  PubMed  Google Scholar 

  70. Oberg S. Wenner J. Johansson J. Walther B. Willén R, “Barrett esophagus: risk factors for progression to dysplasia and adenocarcinoma.” Ann. Surg., vol. 242, pp. 49–54, Jul, 2005.

    Article  PubMed  Google Scholar 

  71. D. E. Fleischer, R. Odze, B. F. Overholt, J. Carroll, K. J. Chang, A. Das, J. Goldblum, D. Miller, C. J. Lightdale, J. Peters, R. Rothstein, V. K. Sharma, D. Smith, V. Velanovich, H. Wolfsen and G. Triadafilopoulos. (2010, Jul). The case for endoscopic treatment of non-dysplastic and low-grade dysplastic Barrett's esophagus. Dig. Dis. Sci. 55(7), pp. 1918–1931. Available: http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=medl&AN=20405211.

    Article  PubMed  Google Scholar 

  72. B. J. Reid, R. C. Haggitt, C. E. Rubin, G. Roth, C. M. Surawicz, G. Van Belle, K. Lewin, W. M. Weinstein, D. A. Antonioli and H. Goldman, “Observer variation in the diagnosis of dysplasia in Barrett’s esophagus.” Hum. Pathol., vol. 19, pp. 166–178, Feb, 1988.

    Article  PubMed  CAS  Google Scholar 

  73. N. J. Shaheen, P. Sharma, B. F. Overholt, H. C. Wolfsen, R. E. Sampliner, K. K. Wang, J. A. Galanko, M. P. Bronner, J. R. Goldblum, A. E. Bennett, B. A. Jobe, G. M. Eisen, M. B. Fennerty, J. G. Hunter, D. E. Fleischer, V. K. Sharma, R. H. Hawes, B. J. Hoffman, R. I. Rothstein, S. R. Gordon, H. Mashimo, K. J. Chang, V. R. Muthusamy, S. A. Edmundowicz, S. J. Spechler, A. A. Siddiqui, R. F. Souza, A. Infantolino, G. W. Falk, M. B. Kimmey, R. D. Madanick, A. Chak and C. J. Lightdale. (2009, May 28). Radiofrequency ablation in Barrett’s esophagus with dysplasia. N. Engl. J. Med. 360(22), pp. 2277–2288. Available: http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=medl&AN=19474425.

    Article  PubMed  CAS  Google Scholar 

  74. S. Wani, S. R. Puli, N. J. Shaheen, B. Westhoff, S. Slehria, A. Bansal, A. Rastogi, H. Sayana and P. Sharma. (2009, Feb). Esophageal adenocarcinoma in Barrett’s esophagus after endoscopic ablative therapy: A meta-analysis and systematic review. Am. J. Gastroenterol. 104(2), pp. 502–513. Available: http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=medl&AN=19174812.

    Article  PubMed  Google Scholar 

  75. A. Das, C. Wells, H. J. Kim, D. E. Fleischer, M. D. Crowell and V. K. Sharma. (2009, May). An economic analysis of endoscopic ablative therapy for management of nondysplastic Barrett’s esophagus. Endoscopy 41(5), pp. 400–408. Available: http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=medl&AN=19418393.

    Article  PubMed  CAS  Google Scholar 

  76. H. J. Stein, M. Feith, B. L. Bruecher, J. Naehrig, M. Sarbia and J. R. Siewert, “Early esophageal cancer: pattern of lymphatic spread and prognostic factors for long-term survival after surgical resection.” Ann. Surg., vol. 242, pp. 566–573, discussion 573–5; Oct, 2005.

    PubMed  Google Scholar 

  77. H. Fujita, S. Sueyoshi, H. Yamana, K. Shinozaki, U. Toh, Y. Tanaka, T. Mine, M. Kubota, K. Shirouzu, A. Toyonaga, H. Harada, S. Ban, M. Watanabe, Y. Toda, E. Tabuchi, N. Hayabuchi and H. Inutsuka, “Optimum treatment strategy for superficial esophageal cancer: endoscopic mucosal resection versus radical esophagectomy.” World J. Surg., vol. 25, pp. 424–431, Apr, 2001.

    Article  PubMed  CAS  Google Scholar 

  78. C. G. Peyre, S. R. DeMeester, C. Rizzetto, N. Bansal, A. L. Tang, S. Ayazi, J. M. Leers, J. C. Lipham, J. A. Hagen and T. R. DeMeester, “Vagal-sparing esophagectomy: the ideal operation for intramucosal adenocarcinoma and Barrett with high-grade dysplasia.” Ann. Surg., vol. 246, pp. 665–671, discussion 671–4; Oct, 2007.

    Article  PubMed  Google Scholar 

  79. M. Vieth, C. Ell, L. Gossner, A. May and M. Stolte, “Histological analysis of endoscopic resection specimens from 326 patients with Barrett’s esophagus and early neoplasia.” Endoscopy, vol. 36, pp. 776–781, Sep, 2004.

    Article  PubMed  CAS  Google Scholar 

  80. B. J. Dunkin, J. Martinez, P. A. Bejarano, C. D. Smith, K. Chang, A. S. Livingstone and W. S. Melvin. (2006, Jan). Thin-layer ablation of human esophageal epithelium using a bipolar radiofrequency balloon device. Surg. Endosc. 20(1), pp. 125–130. Available: http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med4&AN=16333533.

    Article  PubMed  CAS  Google Scholar 

  81. H. Heinrich and P. Bauerfeind, “Endoscopic mucosal resection for staging and therapy of adenocarcinoma of the esophagus, gastric cardia, and upper gastric third,” Recent Results Cancer Res., vol. 182, pp. 85–91, 2010.

    Article  PubMed  Google Scholar 

  82. A. Das, V. Singh, D. E. Fleischer and V. K. Sharma. (2008, Jun). A comparison of endoscopic treatment and surgery in early esophageal cancer: An analysis of surveillance epidemiology and end results data. Am. J. Gastroenterol. 103(6), pp. 1340–1345. Available: http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=medl&AN=18510606.

    Article  PubMed  Google Scholar 

  83. J. Zehetner, S. R. DeMeester, J. A. Hagen, S. Ayazi, F. Augustin, J. C. Lipham and T. R. DeMeester. (2011, Jan). Endoscopic resection and ablation versus esophagectomy for high-grade dysplasia and intramucosal adenocarcinoma. J. Thorac. Cardiovasc. Surg. 141(1), pp. 39–47. Available: http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=medl&AN=21055772.

    Article  PubMed  Google Scholar 

  84. D. K. Rex, O. W. Cummings, M. Shaw, M. D. Cumings, R. K. Wong, R. S. Vasudeva, D. Dunne, E. Y. Rahmani and D. J. Helper, “Screening for Barrett’s esophagus in colonoscopy patients with and without heartburn.” Gastroenterology, vol. 125, pp. 1670–1677, Dec, 2003.

    Article  PubMed  Google Scholar 

  85. D. A. Corley, A. Kubo, T. R. Levin, G. Block, L. Habel, G. Rumore, C. Quesenberry and P. Buffler. (2009, Feb). Race, ethnicity, sex and temporal differences in Barrett's oesophagus diagnosis: A large community-based study, 1994–2006. Gut 58(2), pp. 182–188. Available: http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=medl&AN=18978173.

    Article  PubMed  CAS  Google Scholar 

  86. L. B. Gerson, K. Shetler and G. Triadafilopoulos, “Prevalence of Barrett’s esophagus in asymptomatic individuals.” Gastroenterology, vol. 123, pp. 461–467, Aug, 2002.

    Article  PubMed  Google Scholar 

  87. J. A. Abrams, S. Fields, C. J. Lightdale and A. I. Neugut. (2008, Jan). Racial and ethnic disparities in the prevalence of Barrett’s esophagus among patients who undergo upper endoscopy. Clin. Gastroenterol. Hepatol. 6(1), pp. 30–34. Available: http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=medl&AN=18063419.

    Article  PubMed  Google Scholar 

  88. R. M. Zagari, L. Fuccio, M. A. Wallander, S. Johansson, R. Fiocca, S. Casanova, B. Y. Farahmand, C. C. Winchester, E. Roda and F. Bazzoli. (2008, Oct). Gastro-oesophageal reflux symptoms, oesophagitis and Barrett's oesophagus in the general population: The loiano-monghidoro study. Gut 57(10), pp. 1354–1359. Available: http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=medl&AN=18424568.

    Article  PubMed  CAS  Google Scholar 

  89. B. Westhoff, S. Brotze, A. Weston, C. McElhinney, R. Cherian, M. S. Mayo, H. J. Smith and P. Sharma, “The frequency of Barrett’s esophagus in high-risk patients with chronic GERD.” Gastrointest. Endosc., vol. 61, pp. 226–231, Feb, 2005.

    Article  PubMed  Google Scholar 

  90. S. J. Veldhuyzen van Zanten, A. B. Thomson, A. N. Barkun, D. Armstrong, N. Chiba, R. J. White, S. Escobedo and P. Sinclair, “The prevalence of Barrett’s oesophagus in a cohort of 1040 Canadian primary care patients with uninvestigated dyspepsia undergoing prompt endoscopy.” Aliment. Pharmacol. Ther., vol. 23, pp. 595–599, Mar 1, 2006.

    Article  PubMed  CAS  Google Scholar 

  91. N. Ishimura, Y. Amano and Y. Kinoshita. (2009, Oct). Endoscopic definition of esophagogastric junction for diagnosis of Barrett’s esophagus: Importance of systematic education and training. Dig. Endosc. 21(4), pp. 213–218. Available: http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=medl&AN=19961518.

    Article  PubMed  Google Scholar 

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  1. Department of Surgery, School of Medicine, Oregon Health Sciences University, 3181 SW Sam Jackson Road, Portland, OR, 97239, USA

    Erin W. Gilbert, Renato A. Luna, Vincent L. Harrison & John G. Hunter

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Gilbert, E.W., Luna, R.A., Harrison, V.L. et al. Barrett’s Esophagus: A Review of the Literature. J Gastrointest Surg 15, 708–718 (2011). https://doi.org/10.1007/s11605-011-1485-y

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