Abstract
Purpose
To compare oral rehydration solution (ORS) with saline infusion for preventing contrast-induced nephropathy (CIN) in a rat model.
Materials and methods
Adult male Sprague–Dawley rats (310–360 g) received intravenous indomethacin (10 mg/kg), N G-nitro-l-arginine methyl ester (10 mg/kg), and iohexol (10 mL/kg) to induce acute contrast-induced renal injury (CIN group); control rats received saline only. For hydration, rats received either continuous infusion (20 mL/kg/h) of saline or three oral doses (20 mL/kg each) of ORS. Acute renal injury was evaluated by assaying urine collected for 24 h beginning 2 h before the contrast injection, evaluating blood taken 22 h after the contrast injection, and examining the kidneys histopathologically.
Results
Hydration with saline prevented only the contrast-induced increase in plasma creatinine, whereas ORS prevented deleterious changes in plasma creatinine, blood urea nitrogen, and creatinine clearance as well as in urinary protein, albumin, and N-acetyl-d-glucosaminidase concentrations. Histopathologic changes noted in the CIN group were diminished in both saline and ORS groups.
Conclusion
Both intravenous saline administration and oral hydration with ORS decreased the severity of CIN. Hydration with ORS was comparable to intravenous saline infusion in preventing CIN-associated abnormalities.
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Acknowledgements
For experimental accomplishment, the author received technical support of Otsuka Pharmaceutical Factory, Inc which was the affiliation of the joint author. We thank Atsushi Tosaka (Otsuka Pharmaceutical Factory, Inc) for technical assistance in animal experiment.
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TM, RD, and RK declare that they have no conflict of interest. KH, SM, and GE are employees of the Otsuka Pharmaceutical Factory, Inc.
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Matsunami, T., Hino, K., Dosho, R. et al. Efficacy of oral supplemental hydration for the prevention of contrast-induced nephropathy in rats. Jpn J Radiol 35, 190–196 (2017). https://doi.org/10.1007/s11604-017-0620-4
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DOI: https://doi.org/10.1007/s11604-017-0620-4