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Hypofractionated stereotactic radiotherapy (HFSRT) for who grade I anterior clinoid meningiomas (ACM)

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Abstract

Purpose

While microsurgical resection plays a central role in the management of ACMs, extensive surgery may be associated with substantial morbidity particularly for tumors in intimate association with critical structures. In this study, we evaluated the use of HFSRT in the management of ACM.

Materials and methods

A total of 22 patients with ACM were treated using HFSRT. Frameless image guided volumetric modulated arc therapy (VMAT) was performed with a 6 MV linear accelerator (LINAC). The total dose was 25 Gy delivered in five fractions over five consecutive treatment days. Local control (LC) and progression free survival (PFS) rates were calculated using the Kaplan–Meier method. Common Terminology Criteria for Adverse Events, version 4.0 was used in toxicity grading.

Results

Out of the total 22 patients, outcomes of 19 patients with at least 36 months of periodic follow-up were assessed. Median patient age was 40 years old (range 24–77 years old). Median follow-up time was 53 months (range 36–63 months). LC and PFS rates were 100 and 89.4 % at 1 and 3 years, respectively. Only two patients (10.5 %) experienced clinical deterioration during the follow-up period.

Conclusion

LINAC-based HFSRT offers high rates of LC and PFS for patients with ACMs.

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Acknowledgments

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Authors and Affiliations

  1. Department of Radiation Oncology, Gulhane Medical School, Ankara, Turkey

    Selcuk Demiral, Ferrat Dincoglan, Omer Sager, Hakan Gamsiz, Bora Uysal, Esin Gundem, Yelda Elcim, Bahar Dirican & Murat Beyzadeoglu

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  1. Selcuk Demiral
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  2. Ferrat Dincoglan
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  3. Omer Sager
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  4. Hakan Gamsiz
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  5. Bora Uysal
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  8. Bahar Dirican
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  9. Murat Beyzadeoglu
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Correspondence to Selcuk Demiral.

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Ethical statement

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards.

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Informed consent was obtained from all individual participants included in the study.

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Demiral, S., Dincoglan, F., Sager, O. et al. Hypofractionated stereotactic radiotherapy (HFSRT) for who grade I anterior clinoid meningiomas (ACM). Jpn J Radiol 34, 730–737 (2016). https://doi.org/10.1007/s11604-016-0581-z

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  • DOI: https://doi.org/10.1007/s11604-016-0581-z

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