Skip to main content
SpringerLink
Log in

Exposure to Mozart music reduces cognitive impairment in pilocarpine-induced status epilepticus rats

  • Research Article
  • Published:
Cognitive Neurodynamics Aims and scope Submit manuscript

Abstract

Patients with temporal lobe epilepsy (TLE) often display cognitive deficits. However, current epilepsy therapeutic interventions mainly aim at how to reduce the frequency and degree of epileptic seizures. Recovery of cognitive impairment is not attended enough, resulting in the lack of effective approaches in this respect. In the pilocarpine-induced temporal lobe epilepsy rat model, memory impairment has been classically reported. Here we evaluated spatial cognition changes at different epileptogenesis stages in rats of this model and explored the effects of long-term Mozart music exposure on the recovery of cognitive ability. Our results showed that pilocarpine rats suffered persisting cognitive impairment during epileptogenesis. Interestingly, we found that Mozart music exposure can significantly enhance cognitive ability in epileptic rats, and music intervention may be more effective for improving cognitive function during the early stages after Status epilepticus. These findings strongly suggest that Mozart music may help to promote the recovery of cognitive damage due to seizure activities, which provides a novel intervention strategy to diminish cognitive deficits in TLE patients.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3

Similar content being viewed by others

References

  • Aldenkamp A, Arends J (2004) The relative influence of epileptic EEG discharges, short nonconvulsive seizures, and type of epilepsy on cognitive function. Epilepsia 45:54–63

    Article  PubMed  Google Scholar 

  • Aoun P, Jones T, Shaw GL, Bodner M (2005) Long-term enhancement of maze learning in mice via a generalized Mozart effect. Neurol Res 27:791–796

    Article  PubMed  Google Scholar 

  • Bodner M, Muftuler LT, Nalcioglu O et al (2001) FMRI study relevant to the Mozart effect: brain areas involved in spatial-temporal reasoning. Neurol Res 23:683–690

    Article  CAS  PubMed  Google Scholar 

  • Bridgett DJ, Cuevas J (2000) Effects of listening to Mozart and Bach on the performance of a mathematical test. Percept Mot Skills 90(3):1171–1175

    Article  CAS  PubMed  Google Scholar 

  • Brown SR (2013) Emergence in the central nervous system. Cogn Neurodyn 7(3):173–195

    Article  PubMed Central  PubMed  Google Scholar 

  • Caldwell GN, Riby LM (2006) The effect of music exposure and own genre preference on conscious and unconscious cognitive processes: a pilot ERP study. Conscious Cognit 16:992–996

    Article  Google Scholar 

  • Castren E, Zafra F, Thoenen H et al (1992) Light regulates expression of brain-derived neurotrophic factor mRNA in rat visual cortex. Proc Natl Acad Sci USA 89(20):9444–9448

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  • Chauvière L, Rafrafi N, Thinus-Blanc C et al (2009) Early deficits in spatial memory and theta rhythm in experimental temporal lobe epilepsy. J Neurosci 29(17):5402–5410

    Article  PubMed  Google Scholar 

  • Chikahisa S, Sei H, Morishima M et al (2006) Exposure to music in the perinatal period enhances learning performance and alters BDNF/TrkB signaling in mice as adults. Behav Brain Res 169(2):312–319

    Article  CAS  PubMed  Google Scholar 

  • Curia G, Longo D, Biagini G et al (2008) The pilocarpine model of temporal lobe epilepsy. J Neurosci Methods 172:143–157

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  • Drane DL, Meador KJ (2002) Cognitive and behavioral effects of antiepileptic drugs. Epilepsy Behav 3(5 Suppl):S49–S53

    Article  Google Scholar 

  • Eichenbaum H (1999) Conscious awareness, memory and the hippocampus. Nat Neurosci 2:775–776

    Article  CAS  PubMed  Google Scholar 

  • Faure JB, Akimana G, Carneiro JE et al (2013) A comprehensive behavioral evaluation in the lithium–pilocarpine model in rats: effects of carisbamate administration during status epilepticus. Epilepsia 54:1203–1213

    Article  CAS  PubMed  Google Scholar 

  • Foster NA, Valentine ER (2001) The effect of auditory stimulation on autobiographical recall in dementia. Exp Aging Res 27:215–228

    Article  CAS  PubMed  Google Scholar 

  • Howe AG, Levy WB (2007) A hippocampal model predicts a fluctuating phase transition when learning certain trace conditioning paradigms. Cogn Neurodyn 1(2):143–155

    Article  PubMed Central  PubMed  Google Scholar 

  • Hughes JR (2001) The Mozart effect. Epilepsy Behav 2(5):396–417

    Article  PubMed  Google Scholar 

  • Hughes JR, Daaboul Y, Fino JJ et al (1998) The ‘Mozart effect’ on epileptiform activity. Clin Electroencephgr 29(3):109–119

    Article  CAS  Google Scholar 

  • Ivanov VK, Geake JG (2003) The Mozart effect and primary school children. Psychol Music 31:405–413

    Article  Google Scholar 

  • Jokeit H, Luerding R, Ebner A (2000) Cognitive impairment in temporal-lobe epilepsy. Lancet 355:1018–1019

    Article  CAS  PubMed  Google Scholar 

  • Kim H, Lee MH, Chang HK et al (2006) Influence of prenatal noise and music on the spatial memory and neurogenesis in the hippocampus of developing rats. Brain Dev 28(2):109–114

    Article  PubMed  Google Scholar 

  • Kuester G, Rios L, Ortiz A et al (2010) Effect of music on the recovery of a patient with refractory nonconvulsive status epilepticus. Epilepsy Behav 18(4):491–493

    Article  PubMed  Google Scholar 

  • Lin LC, Lee WT, Wu HC (2010) Mozart K.448 and epileptiform discharges: effect of ratio of lower to higher harmonics. Epilepsy Res 89:238–245

    Article  PubMed  Google Scholar 

  • Lin LC, Lee WT, Wang CH et al (2011a) Mozart K.448 acts as a potential add-on therapy in children with refractory epilepsy. Epilepsy Behav 20:490–493

    Article  PubMed  Google Scholar 

  • Lin LC, Lee WT, Wu HC et al (2011b) The long-term effect of listening to Mozart K.448 decreases epileptiform discharges in children with epilepsy. Epilepsy Behav 21(4):420–424

    Article  PubMed  Google Scholar 

  • Lin LC, Juan CT, Chang HW et al (2013) Mozart K.448 attenuates spontaneous absence seizure and related high-voltage rhythmic spike discharges in Long Evans rats. Epilepsy Res 104(3):234–240

    Article  PubMed  Google Scholar 

  • Lin L-C, Ouyang C-S, Chiang C-T et al (2014) Listening to Mozart K.448 decreases electroencephalography oscillatory power associated with an increase in sympathetic tone in adults: a post-intervention study. J R Soc Med Open 5(10):1–7

    Google Scholar 

  • Maguire J (2012) Music and epilepsy: a critical review. Epilepsia 53(6):947–961

    Article  PubMed  Google Scholar 

  • Marques CM, Caboclo LO, da Silva TI et al (2007) Cognitive decline in temporal lobe epilepsy due to unilateral hippocampal sclerosis. Epilepsy Behav 10:477–485

    Article  PubMed  Google Scholar 

  • Meador KJ (2002) Cognitive outcomes and predictive factors in epilepsy. Neurology 58(Suppl 5):S21–S26

    Article  PubMed  Google Scholar 

  • Meador KJ (2006) Cognitive and memory effects of the new antiepileptic drugs. Epilepsy Res 68:63–67

    Article  PubMed  Google Scholar 

  • Meador KJ, Gilliam FG, Kanner AM et al (2001) Cognitive and behavioral effects of antiepileptic drugs. Epilepsy Behav 2(4 Suppl):SS1–SS17

    CAS  PubMed  Google Scholar 

  • Morimoto K, Fahnestock M, Racine RJ (2004) Kindling and status epilepticus models of epilepsy: rewiring the brain. Prog Neurobiol 73:1–60

    Article  CAS  PubMed  Google Scholar 

  • Özdemir HH, Kara M, Yumrutas O et al (2014) Determination of the effects on learning and memory performance and related gene expressions of clothianidin in rat models. Cogn Neurodyn 8(5):411–416

    Article  PubMed Central  PubMed  Google Scholar 

  • Pacchetti C, Mancini F, Aglieri R (2000) Active music therapy in Parkinson’s disease: an integrative method for motor and emotional rehabilitation. Psychosom Med 62:386–393

    Article  CAS  PubMed  Google Scholar 

  • Racine RJ (1972) Modification of seizure activity by electrical stimulation: II. Motor seizure. Electroencephalogr Clin Neurophysiol 32(3):281–284

    Article  CAS  PubMed  Google Scholar 

  • Raglio A, Farina E, Giovagnoli AR (2014) Can music therapy alleviate psychological, cognitive, and behavioral impairment in epilepsy? Epilepsy Behav 31:7–8

    Article  CAS  PubMed  Google Scholar 

  • Rauscher FH (1993) Music and spatial task performance. Nature 365:611

    Article  CAS  PubMed  Google Scholar 

  • Rauscher FH, Robinson KD, Jens JJ (1998) Improved maze learning through early music exposure in rats. Neurol Res 20:427–432

    CAS  PubMed  Google Scholar 

  • Rutten A, Van Albada M, Silveira DC et al (2002) Memory impairment followingstatus epilepticus in immature rats: time-course and environmental effects. Eur J Neurosci 16(3):501–513

    Article  PubMed  Google Scholar 

  • Sack O (2006) The power of music. Brain 129:2528–2832

    Article  Google Scholar 

  • Särkämö T, Tervaniemi M, Laitinen S et al (2008) Music listening enhances cognitive recovery and mood after middle cerebral artery stroke. Brain 131(3):866–876

    Article  PubMed  Google Scholar 

  • Seth AK (2008) Causal networks in simulated neural systems. Cogn Neurodyn 2(1):49–64

    Article  PubMed Central  PubMed  Google Scholar 

  • Tellez-Zenteno JF, Hernandez-Ronquillo L (2012) A review of the epidemiology of temporal lobe epilepsy. Epilepsy Res Treat 12:1–5

    Article  Google Scholar 

  • Turner RP (2004) The acute effect of music on interictal epileptiform discharges. Epilepsy Behav 5:662–668

    Article  PubMed  Google Scholar 

  • Turski WA, Cavalheiro EA, Schwarz M et al (1983) Limbic seizures produced by pilocarpine in rats: a behavioral, electroencephalographic and neuropathological study. Behav Brain Res 9:315–335

    Article  CAS  PubMed  Google Scholar 

  • Van Praag H, Kempermann G, Gage FH (2000) Neural consequences of environmental enrichment. Nat Rev Neurosci 1:191–198

    Article  PubMed  Google Scholar 

  • Wagatsuma H, Yamaguchi Y (2007) Neural dynamics of the cognitive map in the hippocampus. Cogn Neurodyn 1(2):119–141

    Article  PubMed Central  PubMed  Google Scholar 

  • Wieser HG (2004) ILAE Commission on Neurosurgery of Epilepsy. ILAE Commission Report. Mesial temporal lobe epilepsy with hippocampal sclerosis. Epilepsia 45:695–714

    Article  PubMed  Google Scholar 

  • Zhang S (2015) Improvement of cognitive impairment and hallucination by pharmacological and non-pharmacological therapies for a parkinsonism’s disease with dementia. J Neurol Stroke 2(2):00049

    Article  Google Scholar 

Download references

Acknowledgments

This work was supported by the National Natural Science Foundation of China (No. 81371636, 81071222, and 61201278), the 111 Project (B12027) and the PCSIRT project. This study was also funded by the Scientific and Technological Research program of Chongqing Municipal Education Commission (No. KJ121309).

Author information

Authors and Affiliations

  1. Key Laboratory for NeuroInformation of Ministry of Education, School of Life Science and Technology, University of Electronic Science and Technology of China, #4, Section 2, North Jian She Road, Chengdu, 610054, People’s Republic of China

    Yingshou Xing, Yi Qin, Wei Jing, Yunxiang Zhang, Yanran Wang, Daqing Guo, Yang Xia & Dezhong Yao

  2. Center for Information in Medicine, University of Electronic Science and Technology of China, Chengdu, 610054, People’s Republic of China

    Daqing Guo, Yang Xia & Dezhong Yao

  3. The School of Electronic Information Engineering, Yangtze Normal University, Chongqing, Fuling, 408100, People’s Republic of China

    Yingshou Xing

Authors
  1. Yingshou Xing
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Yi Qin
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Wei Jing
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Yunxiang Zhang
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Yanran Wang
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Daqing Guo
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Yang Xia
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. Dezhong Yao
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Yang Xia.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Xing, Y., Qin, Y., Jing, W. et al. Exposure to Mozart music reduces cognitive impairment in pilocarpine-induced status epilepticus rats. Cogn Neurodyn 10, 23–30 (2016). https://doi.org/10.1007/s11571-015-9361-1

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s11571-015-9361-1

Keywords

Search

Navigation