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Desynchronizing effect of high-frequency stimulation in a generic cortical network model

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Abstract

Transcranial electrical stimulation (TCES) and deep brain stimulation are two different applications of electrical current to the brain used in different areas of medicine. Both have a similar frequency dependence of their efficiency, with the most pronounced effects around 100 Hz. We apply superthreshold electrical stimulation, specifically depolarizing DC current, interrupted at different frequencies, to a simple model of a population of cortical neurons which uses phenomenological descriptions of neurons by Izhikevich and synaptic connections on a similar level of sophistication. With this model, we are able to reproduce the optimal desynchronization around 100 Hz, as well as to predict the full frequency dependence of the efficiency of desynchronization, and thereby to give a possible explanation for the action mechanism of TCES.

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Acknowledgments

Financial support by the Deutsche Forschungsgemeinschaft (DFG SFB-654 project A8 and Graduate School for Computing in Medicine and Life Science) is gratefully acknowledged.

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  1. Institute for Neuro- and Bioinformatics, Universität zu Lübeck, 23538, Lübeck, Germany

    Markus Schütt & Jens Christian Claussen

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  1. Markus Schütt
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  2. Jens Christian Claussen
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Correspondence to Jens Christian Claussen.

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Schütt, M., Claussen, J.C. Desynchronizing effect of high-frequency stimulation in a generic cortical network model. Cogn Neurodyn 6, 343–351 (2012). https://doi.org/10.1007/s11571-012-9199-8

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