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3-Tesla MR spectroscopy in patients subjected to bone marrow transplantation: clinical correlations

Spettroscopia-RM a 3 T nei pazienti sottoposti a trapianto di midollo osseo: correlazioni cliniche

  • Musculoskeletal Radiology / Radiologia Muscolo-Scheletrica
  • Published:
La radiologia medica Aims and scope Submit manuscript

Abstract

Purpose

This study evaluated the usefulness of 3-Tesla magnetic resonance (MR) spectroscopy in patients with non-Hodgkin’s lymphoma (NHL) undergoing bone marrow transplantation (BMT).

Materials and methods

Twelve NHL patients who were candidates for BMT underwent three MR examinations of the lumbosacral spine: before ablative therapy for BMT, 15±4 days and 54±24 days after BMT. The MR study was supplemented by spectroscopic analysis. The lipid content was calculated and expressed as a percentage of lipid signal intensity relative to total signal intensity [fat fraction (FF)].

Results

In the first MR study, the FF was 62.5±7%, in the second it was 70.75±5% and in the third it was 75±1%. We observed a statistically significant difference between FF values calculated at the various MR studies (p=0.02) and between red blood cell count (p=0.017), platelet count (p=0.003) and haematocrit (p<0.001) at the three MR studies. FF had a statistically significant correlation with the number of circulating platelets (p<0.01)

Conclusions

MR spectroscopy of the bone marrow of NHL patients undergoing BMT is noninvasive and highly sensitive for characterising and monitoring bone marrow after BMT.

Riassunto

Obiettivo

Scopo del presente lavoro è stato valutare l’utilità della spettroscopia mediante risonanza magnetica (RM) a 3 tesla nei pazienti affetti da linfoma non-Hodgkin (LNH) sottoposti a trapianto di midollo osseo (TMO).

Materiali e metodi

Dodici pazienti affetti da LNH candidati al TMO sono stati sottoposti a 3 esami RM del rachide lombo-sacrale: prima della terapia ablativa per il TMO, dopo 15±4 giorni dal TMO e dopo 54±24 giorni. Lo studio RM è stato integrato con analisi spettroscopica. è stato calcolato il contenuto di lipidi, espresso in percentuale come intensità di segnale relativa dei lipidi rispetto all’intensità di segnale totale (fat fraction, FF).

Risultati

Nel primo studio RM si riscontrava una FF=62,5%±7%; nel secondo una FF=70,75%±5%; nel terzo una FF=75%±1%. Abbiamo osservato una differenza statisticamente significativa tra i valori di FF calcolati ai vari controlli RM (p=0,02), tra il numero dei globuli rossi (p=0,017), delle piastrine (p=0,003) e tra i valori dell’ematocrito (p<0,001) tra i tre controlli RM. La FF presenta una correlazione statisticamente significativa con il numero delle piastrine circolanti (p<0,01).

Conclusioni

La RM con studio spettroscopico del midollo osseo su pazienti con LNH sottoposti a TMO rappresenta una metodica non invasiva e molto sensibile nella caratterizzazione e monitoraggio del midollo osseo dopo TMO.

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Authors and Affiliations

  1. Dipartimento di Diagnostica per Immagini, Imaging Molecolare, Radiologia Interventistica e Radioterapia, Fondazione Policlinico Universitario “Tor Vergata”, Viale Oxford 81, 00133, Roma, Italy

    G. Sergiacomi, E. Gaspari, A. Taglieri, A. Meschini, V. Gisone, L. Cudillo, W. Arcese & G. Simonetti

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  1. G. Sergiacomi
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  2. E. Gaspari
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  3. A. Taglieri
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  4. A. Meschini
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  5. V. Gisone
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  6. L. Cudillo
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  7. W. Arcese
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  8. G. Simonetti
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Correspondence to G. Sergiacomi.

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Sergiacomi, G., Gaspari, E., Taglieri, A. et al. 3-Tesla MR spectroscopy in patients subjected to bone marrow transplantation: clinical correlations. Radiol med 118, 101–111 (2013). https://doi.org/10.1007/s11547-012-0796-8

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  • DOI: https://doi.org/10.1007/s11547-012-0796-8

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