Original Article

Bulletin of Mathematical Biology

, Volume 74, Issue 2, pp 346-355

First online:

Electromigration Dispersion in Capillary Electrophoresis

  • Zhen ChenAffiliated withDept. Mech. Eng., Northwestern University
  • , Sandip GhosalAffiliated withDept. Mech. Eng., Northwestern University Email author 

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In a previous paper (Ghosal and Chen in Bull. Math. Biol. 72:2047, 2010), it was shown that the evolution of the solute concentration in capillary electrophoresis is described by a nonlinear wave equation that reduced to Burger’s equation if the nonlinearity was weak. It was assumed that only strong electrolytes (fully dissociated) were present. In the present paper, it is shown that the same governing equation also describes the situation where the electrolytic buffer consists of a single weak acid (or base). A simple approximate formula is derived for the dimensionless peak variance which is shown to agree well with published experimental data.


Capillary electrophoresis Electromigration dispersion