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Advanced computational workflow for the multi-scale modeling of the bone metabolic processes

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Abstract

Multi-scale modeling of the musculoskeletal system plays an essential role in the deep understanding of complex mechanisms underlying the biological phenomena and processes such as bone metabolic processes. Current multi-scale models suffer from the isolation of sub-models at each anatomical scale. The objective of this present work was to develop a new fully integrated computational workflow for simulating bone metabolic processes at multi-scale levels. Organ-level model employs multi-body dynamics to estimate body boundary and loading conditions from body kinematics. Tissue-level model uses finite element method to estimate the tissue deformation and mechanical loading under body loading conditions. Finally, cell-level model includes bone remodeling mechanism through an agent-based simulation under tissue loading. A case study on the bone remodeling process located on the human jaw was performed and presented. The developed multi-scale model of the human jaw was validated using the literature-based data at each anatomical level. Simulation outcomes fall within the literature-based ranges of values for estimated muscle force, tissue loading and cell dynamics during bone remodeling process. This study opens perspectives for accurately simulating bone metabolic processes using a fully integrated computational workflow leading to a better understanding of the musculoskeletal system function from multiple length scales as well as to provide new informative data for clinical decision support and industrial applications.

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Acknowledgments

The author would like to thank P. Pouletaut for his assistance in the development of finite element model of the jaw system.

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Authors and Affiliations

  1. Sorbonne University, Université de Technologie de Compiègne, CNRS, UMR 7338 Biomechanics and Bioengineering, Centre de recherche Royallieu, CS 60 319, 60203, Compiègne Cedex, France

    Tien Tuan Dao

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Correspondence to Tien Tuan Dao.

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Dao, T.T. Advanced computational workflow for the multi-scale modeling of the bone metabolic processes. Med Biol Eng Comput 55, 923–933 (2017). https://doi.org/10.1007/s11517-016-1572-z

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  • DOI: https://doi.org/10.1007/s11517-016-1572-z

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