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Hybrid stent device of flow-diverting effect and stent-assisted coil embolization formed by fractal structure

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Abstract

This paper presents a novel hybrid medical stent device. This hybrid stent device formed by fractal mesh structures provides a flow-diverting effect and stent-assisted coil embolization. Flow-diverter stents decrease blood flow into an aneurysm to prevent its rupture. In general, the mesh size of a flow-diverter stent needs to be small enough to prevent blood flow into the aneurysm. Conventional flow-diverter stents are not available for stent-assisted coil embolization, which is an effective method for aneurysm occlusion, because the mesh size is too small to insert a micro-catheter for coil embolization. The proposed hybrid stent device is capable of stent-assisted coil embolization while simultaneously providing a flow-diverting effect. The fractal stent device is composed of mesh structures with fine and rough mesh areas. The rough mesh area can be used to insert a micro-catheter for stent-assisted coil embolization. Flow-diverting effects of two fractal stent designs were composed to three commercially available stent designs. Flow-diverting effects were analyzed using computational fluid dynamics (CFD) analysis and particle image velocimetry (PIV) experiment. Based on the CFD and PIV results, the fractal stent devices reduce the flow velocity inside an aneurism just as much as the commercially available flow-diverting stents while allowing stent-assisted coil embolization.

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References

  1. Armoiry X, Paysant M, Hartmann D, Aulagner G, Turjman F (2012) Interest of flow diversion prostheses in the management of unruptured intracranial aneurysms. Int J Vasc Med 2012:1–5. doi:10.1155/2012/654627

    Article  Google Scholar 

  2. Henkes H, Bose A, Felber S, Miloslavski E, Berg-Dammer E, Kuhne D (2002) Endovascular coil occlusion of intracranial aneurysms assisted by a novel self-expandable nitinol microstent (neuroform). Interv Neuroradiol 8:107–120

    CAS  PubMed  PubMed Central  Google Scholar 

  3. Hurst D, Vassilicos JC (2007) Scalings and decay of fractal-generated turbulence. Phys Fluids 19:035103

    Article  Google Scholar 

  4. Ikeda S, Arai F, Fukuda T, Negoro M, Irie K (2005) an in vitro patient-specific biological model of the cerebral artery reproduced with a membranous configuration for simulating endovascular intervention. J Robot Mechatron 17:327–334

    Google Scholar 

  5. Jeong W, Han MH, Rhee K (2013) Effects of framing coil shape, orientation, and thickness on intra-aneurysmal flow. Med Biol Eng Comput 51:981–990

    Article  PubMed  Google Scholar 

  6. Kojima M, Irie K, Fukuda T, Arai F, Hirose Y, Negoro M (2012) The study of flow diversion effects on aneurysm using multiple enterprise stents and two flow diverters. Asian J Neurosurg 7:159–165

    Article  PubMed  PubMed Central  Google Scholar 

  7. Kojima M, Irie K, Ikeda S, Fukuda T, Arai F, Hirose Y, Negoro M (2012) The hemodynamic study for growth factor evaluation of rupture cerebral aneurysm followed up for five years. J Biomed Sci Eng 5:884–891

    Article  Google Scholar 

  8. Lubicz B, Collignon L, Raphaeli G, Pruvo JP, Bruneau M, Witte OD, Leclerc X (2010) Flowdiverter stent for the endovascular treatment of intracranial aneurysms a prospective study in 29 patients with 34 aneurysms. Stroke 41:2247–2253

    Article  PubMed  Google Scholar 

  9. Lylyk P, Cohen JE, Ceratto R, Ferrario A, Miranda C (2002) Endovascular reconstruction of intracranial arteries by stent placement and combined techniques. J Neurosurg 97:1306–1313

    Article  PubMed  Google Scholar 

  10. Lylyk P, Miranda C, Ceratto R, Ferrario A, Scrivano E, Luna HR, Berez AL, Tran Q, Nelson PK, Fiorella D (2009) Curative endovascular reconstruction of cerebral aneurysms with the pipeline embolization device: the buenos aires experience. Neurosurgery 64:632–643

    Article  PubMed  Google Scholar 

  11. Mazellier N, Vassilicos JC (2010) Turbulence without Richardson–Kolmogorov cascade. Phys Fluids 22:075101

    Article  Google Scholar 

  12. Mehta B, Burke T, Kole M, Bydon A, Seyfried D, Malik G (2003) Stent-within-a-stent technique for the treatment of dissecting vertebral artery aneurysms. Am J Neuroradiol 24:1814–1818

    PubMed  Google Scholar 

  13. Nagata K, Sakai Y, Inaba T, Suzuki H, Terashima O, Suzuki H (2013) Turbulence structure and turbulence kinetic energy transport in multiscale/fractal-generated turbulence. Phys Fluids 25:065102

    Article  Google Scholar 

  14. Nelson PK, Lylyk P, Szikora I, Wetzel SG, Wanke I, Fiorella D (2011) The pipeline embolization device for the intracranial treatment of aneurysms trial. Am J Neuroradiol 32:34–40

    Article  CAS  PubMed  Google Scholar 

  15. Otani T, Nakamura M, Fujinaka T, Hirata M, Kuroda J, Shibano K, Wada S (2013) Computational fluid dynamics of blood flow in coil-embolized aneurysms: effect of packing density on flow stagnation in an idealized geometry. Med Biol Eng Comput 51:901–910

    Article  PubMed  Google Scholar 

  16. Pedley TJ (1980) The fluid mechanics of large blood vessels. Cambridge University Press, Cambridge

    Book  Google Scholar 

  17. Seoud RE, Vassilicos JC (2007) Dissipation and decay of fractal-generated turbulence. Phys Fluids 19:105108

    Article  Google Scholar 

  18. Shapiro M, Babb J, Becske T, Nelson PK (2008) Safety and efficacy of adjunctive balloon remodeling during endovascular treatment of intracranial aneurysms: a literature review. Am J Neuroradiol 29:1777–1781

    Article  CAS  PubMed  Google Scholar 

  19. Szikora I, Berentei Z, Kulcsar Z, Marosfoi M, Vajda ZS, Lee W, Berez A, Nelson PK (2010) Treatment of intracranial aneurysms by functional reconstruction of the parent artery: the budapest experience with the pipeline embolization device. Am J Neuroradiol 31:1139–1147

    Article  CAS  PubMed  Google Scholar 

  20. Torii R, Oshima M, Kobayashi T, Takagi K, Tezduyar TE (2008) Fluid-structure interaction modeling of a patient-specific cerebral aneurysm: influence of structural modeling. Comput Mech 43:151–159

    Article  Google Scholar 

  21. Torii R, Oshima M, Kobayashi T, Takagi K, Tezduyar TE (2009) Fluid-structure interaction modeling of blood flow and cerebral aneurysm: significance of artery and aneurysm shapes. Comput Methods Appl Mech Eng 198:3613–3621

    Article  Google Scholar 

  22. Vanninen R, Manninen H, Ronkainen A (2003) Broadbased intracranial aneurysms: thrombosis induced by stent placement. Am J Neuroradiol 24:263–266

    PubMed  Google Scholar 

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Acknowledgments

This research is partially supported by the Ministry of Education, Culture, Sports, Science and Technology grant-in-aid scientific research.

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Authors and Affiliations

  1. Department of Micro-Nano Systems Engineering, Nagoya University, Nagoya, Aichi, Japan

    Masahiro Kojima, Masaru Takeuchi & Fumihito Arai

  2. Department of Neurosurgery of Fujita, Health University, Nagoya, Aichi, Japan

    Keiko Irie

  3. Department of Mechanical Science and Engineering, Nagoya University, Nagoya, Aichi, Japan

    Kouhei Masunaga & Yasuhiko Sakai

  4. Center for Micro-Nano Mechatronics, Nagoya University, Furo-cho, Chikusa-ku, Nagoya, Aichi, 464-8603, Japan

    Masahiro Nakajima

  5. Faculty of Science and Engineering, Meijo University, Siogamaguchi 1-501, Tenpaku-ku, Nagoya, Aichi, 468-8502, Japan

    Toshio Fukuda

  6. Institute for Advanced Research, Nagoya University, Nagoya, Aichi, Japan

    Toshio Fukuda

  7. Intelligent Robotics Institute, School of Mechatronical Engineering, Beijing Institute of Technology, Beijing, China

    Toshio Fukuda

  8. Ichinomiyanishi Hospital, Nagoya, Aichi, Japan

    Makoto Negoro

Authors
  1. Masahiro Kojima
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  2. Keiko Irie
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  3. Kouhei Masunaga
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  4. Yasuhiko Sakai
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  5. Masahiro Nakajima
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  6. Masaru Takeuchi
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  7. Toshio Fukuda
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  8. Fumihito Arai
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  9. Makoto Negoro
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Corresponding authors

Correspondence to Masahiro Nakajima or Toshio Fukuda.

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Kojima, M., Irie, K., Masunaga, K. et al. Hybrid stent device of flow-diverting effect and stent-assisted coil embolization formed by fractal structure. Med Biol Eng Comput 54, 831–841 (2016). https://doi.org/10.1007/s11517-015-1374-8

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  • DOI: https://doi.org/10.1007/s11517-015-1374-8

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