Frontiers in Biology

, Volume 6, Issue 6, pp 446-461

First online:

Molecular mechanisms of transcription and replication of the influenza A virus genome

  • Shijian ZhangAffiliated withShanghai Medical College of Fudan University
  • , Tetsuya ToyodaAffiliated withChoju Medical Institute, Fukushimura HospitalInfectious Disease Regulation Project, Tokyo Metropolitan Institute of Medical Sciences Email author 

Rent the article at a discount

Rent now

* Final gross prices may vary according to local VAT.

Get Access


Influenza Avirus is one of the major pathogens that pose a large threat to human health worldwide and has caused pandemics. Influenza A virus is the Orthomyxoviridae prototype, and has 8 segmented negative-sense single-stranded RNA (vRNA) as its genome. Influenza virus RNA polymerase (RdRp) consists of three subunits PB2, PB1 and PA, and catalyzes both transcription and replication. Recently, intensive biochemical and structural analysis of its RdRp has been performed. In this paper, we review the details from the biochemical analysis of the purified influenza virus RdRp and the classical ribonucleoprotein complex, as well as piece together their structures to form an overall picture.


influenza virus RNA polymerase ribonucleoprotein complex transcription replication