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Dopamine Increases CD14+CD16+ Monocyte Transmigration across the Blood Brain Barrier: Implications for Substance Abuse and HIV Neuropathogenesis

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Abstract

In human immunodeficiency virus-1 (HIV) infected individuals, substance abuse may accelerate the development and/or increase the severity of HIV associated neurocognitive disorders (HAND). It is proposed that CD14+CD16+ monocytes mediate HIV entry into the central nervous system (CNS) and that uninfected and infected CD14+CD16+ monocyte transmigration across the blood brain barrier (BBB) contributes to the establishment and propagation of CNS HIV viral reservoirs and chronic neuroinflammation, important factors in the development of HAND. The effects of substance abuse on the frequency of CD14+CD16+ monocytes in the peripheral circulation and on the entry of these cells into the CNS during HIV neuropathogenesis are not known. PBMC from HIV infected individuals were analyzed by flow cytometry and we demonstrate that the frequency of peripheral blood CD14+CD16+ monocytes in HIV infected substance abusers is increased when compared to those without active substance use. Since drug use elevates extracellular dopamine concentrations in the CNS, we examined the effects of dopamine on CD14+CD16+ monocyte transmigration across our in vitro model of the human BBB. The transmigration of this monocyte subpopulation is increased by dopamine and the dopamine receptor agonist, SKF 38393, implicating D1-like dopamine receptors in the increase in transmigration elicited by this neurotransmitter. Thus, elevated extracellular CNS dopamine may be a novel common mechanism by which active substance use increases uninfected and HIV infected CD14+CD16+ monocyte transmigration across the BBB. The influx of these cells into the CNS may increase viral seeding and neuroinflammation, contributing to the development of HIV associated neurocognitive impairments.

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Acknowledgements

Data in this manuscript were collected by the Women’s Interagency HIV Study (WIHS) with the Bronx WIHS principal investigator, Dr. Kathryn Anastos. The contents of this publication are solely the responsibility of the authors and do not represent the official views of the National Institutes of Health (NIH). The WIHS is funded primarily by the National Institute of Allergy and Infectious Diseases (NIAID), with additional co-funding from the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), the National Cancer Institute (NCI), the National Institute on Drug Abuse (NIDA), and the National Institute on Mental Health (NIMH). Targeted supplemental funding for specific projects is also provided by the National Institute of Dental and Craniofacial Research (NIDCR), the National Institute on Alcohol Abuse and Alcoholism (NIAAA), the National Institute on Deafness and other Communication Disorders (NIDCD), and the NIH Office of Research on Women’s Health. The authors thank Dr. Brad Poulos (Fetal Tissue Repository), the New York Blood Center, Dr. Lydia Tesfa (Flow Cytometry Core, Albert Einstein College of Medicine, Montefiore Medical Center), and the patients and staff of the MHBB and WHIS.

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Authors and Affiliations

  1. Department of Pathology, Albert Einstein College of Medicine, Bronx, NY, 10461, USA

    Tina M. Calderon, Dionna W. Williams, Lillie Lopez, Laura Cheney, Peter J. Gaskill, Mike Veenstra & Joan W. Berman

  2. Public Health Research Institute (PHRI), New Jersey Medical School, Rutgers The State University of New Jersey, Newark, NJ, 07103, USA

    Eliseo A. Eugenin

  3. Department of Microbiology and Molecular Genetics, New Jersey Medical School, Rutgers The State University of New Jersey, Newark, NJ, 07103, USA

    Eliseo A. Eugenin

  4. Department of Medicine, Albert Einstein College of Medicine, Bronx, NY, 10461, USA

    Laura Cheney & Kathryn Anastos

  5. Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY, 10461, USA

    Kathryn Anastos

  6. Department of Obstetrics and Gynecology and Women’s Health, Albert Einstein College of Medicine, Bronx, NY, 10461, USA

    Kathryn Anastos

  7. Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA

    Susan Morgello

  8. Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA

    Susan Morgello

  9. Department of Pathology, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA

    Susan Morgello

  10. Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY, 10461, USA

    Joan W. Berman

Authors
  1. Tina M. Calderon
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  2. Dionna W. Williams
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  3. Lillie Lopez
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  4. Eliseo A. Eugenin
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  5. Laura Cheney
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  6. Peter J. Gaskill
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  7. Mike Veenstra
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  8. Kathryn Anastos
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  9. Susan Morgello
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  10. Joan W. Berman
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Corresponding author

Correspondence to Joan W. Berman.

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Funding

This work was supported by U.S. NIH Grants DA025567 (to J.W.B. and T.M.C.), MH075679 and MH090958 (to J.W.B.), DA029476 (to P.J.G.), MH096625 (to E.A.E.), Al035004 and Al142590 (to K.A.), and MH083501 and MH100931 (to S.M.); Mount Sinai Institute for NeuroAIDS Disparities Pilot Funds (MH080663 to D.W.W); United Negro College Fund/Merck Graduate Science Dissertation Fellowship (to D.W.W.); and the Center for AIDS Research at the Albert Einstein College of Medicine, Montefiore Medical Center (CFAR/AI051519).

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The authors declare that they have no conflict of interest.

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Calderon, T.M., Williams, D.W., Lopez, L. et al. Dopamine Increases CD14+CD16+ Monocyte Transmigration across the Blood Brain Barrier: Implications for Substance Abuse and HIV Neuropathogenesis. J Neuroimmune Pharmacol 12, 353–370 (2017). https://doi.org/10.1007/s11481-017-9726-9

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  • DOI: https://doi.org/10.1007/s11481-017-9726-9

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