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Towards Clinical Application of Mesenchymal Stem Cells for Treatment of Neurological Diseases of the Central Nervous System

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Abstract

The diagnosis of a neurological disease of the central nervous system (CNS) is often associated with the anticipation of an irreversible and untreatable disability. This is the case also of multiple sclerosis (MS) where approved treatments effectively modulate the autoimmune attack to myelin antigens, but poorly affect neurodegeneration and do not promote tissue repair. Thus, stem cell-based therapies are increasingly being considered a possible strategy for diseases of the CNS. Mesenchymal stem cells (MSC), the safety of which has been demonstrated in the last 20 years through clinical trials and case studies, are of particular interest in view not only of their neuroprotective, but also of their immunomodulatory properties. Here, we review the therapeutic features of MSC that make them relevant in the treatment of CNS illnesses and discuss the pioneer clinical experience with MSC-based therapy in neurological diseases.

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Authors and Affiliations

  1. Department of Neurosciences Ophthalmology, Genetics, Rehabilitation and Child Health, University of Genoa, Genoa, Italy

    Alice Laroni, Giovanni Novi, Nicole Kerlero de Rosbo & Antonio Uccelli

  2. Advanced Biotechnology Center (ABC), Genoa, Italy

    Nicole Kerlero de Rosbo & Antonio Uccelli

  3. Center of Excellence for Biomedical Research, University of Genoa, Genoa, Italy

    Antonio Uccelli

  4. Department of Neurosciences, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health, University of Genova, Largo Daneo 3, 16132, Genoa, Italy

    Antonio Uccelli

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  1. Alice Laroni
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  2. Giovanni Novi
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  4. Antonio Uccelli
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Correspondence to Antonio Uccelli.

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Laroni, A., Novi, G., Kerlero de Rosbo, N. et al. Towards Clinical Application of Mesenchymal Stem Cells for Treatment of Neurological Diseases of the Central Nervous System. J Neuroimmune Pharmacol 8, 1062–1076 (2013). https://doi.org/10.1007/s11481-013-9456-6

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