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MicroRNAs in Opioid Pharmacology

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Journal of Neuroimmune Pharmacology Aims and scope Submit manuscript

Abstract

MicroRNAs (miRNA), a class of ~22-nucleotide RNA molecules, are important gene regulators that bind to the target sites of mRNAs to inhibit the gene expressions either through translational inhibition or mRNA destabilization. There are growing evidences that miRNAs have played several regulatory roles in opioid pharmacology. Like other research fields such as cancer biology, the area where numerous miRNAs are found to be involved in gene regulation, we assume that in opioid studies including research fields of drug additions and opioid receptor regulation, there may be more miRNAs waiting to be discovered. This review will summarize our current knowledge of miRNA functions on opioids biology and briefly describe future research directions of miRNAs related to opioids.

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Abbreviations

Ago2:

Argonaute 2

BDNF:

Brain-derived neurotrophic factor

CNS:

Central nervous system

CREB:

cAMP-response element binding protein

CYP2D6:

cytochrome P450 2D6

Drd2:

Dopamine 2 receptor

Drd3:

dopamine D3 receptor

ERK:

Extracellular signal-regulated kinase

FGF-2:

Fibroblast growth factor-2

FosB:

FBJ murine osteosarcoma viral oncogene homolog B

GPCR:

G protein-coupled receptor

HEK:

Human embryonic kidney

HIV-1:

Human immunodeficiency virus type 1

MeCP2:

Methyl CpG binding protein 2

MOR:

Mu opioid receptor

NeuroD:

Neurogenic differentiation 1

PKA:

Protein kinase A

PKC:

Protein kinase C

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Acknowledgements

This work was supported by the National Institutes of Health National Institutes of Drug Abuse [Grants DA000564, DA001583, DA011806, K05-DA070554, DA011190, DA013926]; and by the A & F Stark Fund of the Minnesota Medical Foundation. The authors declare no conflict of interest.

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  1. Department of Pharmacology, University of Minnesota Medical School, 6-120 Jackson Hall, 321 Church St. S.E., Minneapolis, MN, 55455, USA

    Cheol Kyu Hwang, Yadav Wagley, Ping-Yee Law, Li-Na Wei & Horace H. Loh

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  1. Cheol Kyu Hwang
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  2. Yadav Wagley
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Correspondence to Cheol Kyu Hwang.

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Hwang, C.K., Wagley, Y., Law, PY. et al. MicroRNAs in Opioid Pharmacology. J Neuroimmune Pharmacol 7, 808–819 (2012). https://doi.org/10.1007/s11481-011-9323-2

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