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Graphene/Graphene Oxide-Based Ultrasensitive Surface Plasmon Resonance Biosensor

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Abstract

Surface plasmon resonance (SPR)-based biosensing is an accurate and sensitive technique used to evaluate the biomolecular interactions in real time in a label-free environment. Several new approaches have been proposed to improve the sensitivity of SPR sensors. The development of sensing surfaces can significantly improve the performance of biosensors; graphene and graphene oxide (GO) offer several advantages due to their extraordinary optical and structural properties. In this paper, the SPR biosensor structure based on graphene and GO linking layers are suggested. For proposed configurations, the features and characteristics such as reflectivity and sensitivity using the finite element analysis (FEA) model are discussed and compared with results from N-layer model. The effect of cap layer thickness in the sensitivity of the SPR biosensor has been calculated. Computational results show that the proposed graphene and GO-based SPR biosensor have more than two and four times greater sensitivity than the conventional gold film-based SPR sensor respectively due to their better adsorption of biomolecules.

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References

  1. Homola J, Yee SS, Gauglitz G (1999) Surface plasmon resonance sensors: review. Sensors Actuators B-Chemical 54(1–2):3–15

    Article  CAS  Google Scholar 

  2. Piliarik M, Vaisocherova H, Homola J (2009) Surface plasmon resonance biosensing. Methods Mol Biol 503:65–88

    Article  CAS  Google Scholar 

  3. Zhang M, Li K, Shum PP et al (2016) Graphene enhanced surface plasmon resonance fiber-optic biosensor. In: Conference on Lasers and Electro-Optics. Optical Society of America, San Jose, California

  4. Kaur G et al (2016) Detection of Neisseria meningitidis using surface plasmon resonance based DNA biosensor. Biosensors & Bioelectronics 78:106–110

    Article  CAS  Google Scholar 

  5. Liedberg B, Nylander C, Lundstrom I (1995) Biosensing with surface plasmon resonance—how it all started. Biosens Bioelectron 10(8):i–ix

    Article  CAS  Google Scholar 

  6. Verma A, Prakash A, Tripathi R (2016) Sensitivity improvement of graphene based surface plasmon resonance biosensors with chaclogenide prism. Optik – Int J Light Electron Optics 127(4):1787–1791

    Article  CAS  Google Scholar 

  7. Homola JI, Dostálek J (2006) Surface plasmon resonance based sensors

  8. Zeng S, Yong K-T, Roy I et al (2011) A review on functionalized gold nanoparticles for biosensing applications. Plasmonics 6(3):491–506

    Article  CAS  Google Scholar 

  9. Zuppella P, Tosatto S, Corso AJ et al (2013) Graphene–noble metal bilayers for inverted surface plasmon resonance biosensors. J Opt 15(5):055010

  10. Bhavsar K, Prabhu R, Pollard P (2015) Ultrasensitive graphene coated SPR sensor for biosensing applications

  11. Subramanian P, Barka-Bouaifel F, Bouckaert J et al (2014) Graphene-coated surface Plasmon resonance interfaces for studying the interactions between bacteria and surfaces. ACS Appl Mater Interfaces 6(8):5422–5431

    Article  CAS  Google Scholar 

  12. Subramanian P, Lesniewski A, Kaminska I et al (2013) Lysozyme detection on aptamer functionalized graphene-coated SPR interfaces. Biosens Bioelectron 50:239–243

    Article  CAS  Google Scholar 

  13. Pei S, Cheng H-M (2012) The reduction of graphene oxide. Carbon 50(9):3210–3228

    Article  CAS  Google Scholar 

  14. Yushanov SP, Gritter LT, Crompton JS et al (2012) Surface plasmon resonance. In: Proceedings of the 2012 COMSOL Conference in Boston. www.comsol.com/offers/conference2012papers/papers/presentation/area/optics/id/13685/

  15. Born M, Wolf E, Bhatia AB et al (2000) Principles of optics: electromagnetic theory of propagation, interference and diffraction of light. Cambridge University Press, Cambridge

    Google Scholar 

  16. Liu L, Ryu S, Tomasik MR et al (2008) Graphene oxidation: thickness-dependent etching and strong chemical doping. Nano Lett 8(7):1965–1970

    Article  CAS  Google Scholar 

  17. Homola J (2003) Present and future of surface plasmon resonance biosensors. Anal Bioanal Chem 377(3):528–539

    Article  CAS  Google Scholar 

  18. Liu J (2012) Adsorption of DNA onto gold nanoparticles and graphene oxide: surface science and applications. Phys Chem Chem Phys 14(30):10485–10496

    Article  CAS  Google Scholar 

  19. Bruna M, Borini S (2009) Optical constants of graphene layers in the visible range. Appl Phys Lett 94(3):031901

    Article  Google Scholar 

  20. Jung I, Vaupel M, Pelton M et al (2008) Characterization of thermally reduced graphene oxide by imaging ellipsometry. J Phys Chem C 112(23):8499–8506

  21. Elhadj S, Singh G, Saraf RF (2004) Optical properties of an immobilized DNA monolayer from 255 to 700 nm. Langmuir 20(13):5539–5543

    Article  CAS  Google Scholar 

  22. Choi SH, Kim YL, Byun KM (2011) Graphene-on-silver substrates for sensitive surface plasmon resonance imaging biosensors. Opt Express 19(2):458–466

    Article  CAS  Google Scholar 

  23. Song B, Li D, Qi W et al (2010) Graphene on Au(111): a highly conductive material with excellent adsorption properties for high-resolution bio/nanodetection and identification. Chem Phys Chem 11(3):585–589

    Article  CAS  Google Scholar 

  24. Stebunov YV, Aftenieva OA, Arsenin AV et al (2015) Highly sensitive and selective sensor chips with graphene-oxide linking layer. ACS Appl Mater Interfaces 7(39):21727–21734

    Article  CAS  Google Scholar 

Download references

Acknowledgements

The authors would like to acknowledge the Computational Nanoelectronic Research Group (Cone) at the Faculty of Electrical Engineering, Universiti Teknologi Malaysia, for their support and contribution to this study under visiting research program.

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Correspondence to Mohammad Taghi Ahmadi.

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Meshginqalam, B., Ahmadi, M.T., Ismail, R. et al. Graphene/Graphene Oxide-Based Ultrasensitive Surface Plasmon Resonance Biosensor. Plasmonics 12, 1991–1997 (2017). https://doi.org/10.1007/s11468-016-0472-2

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  • DOI: https://doi.org/10.1007/s11468-016-0472-2

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