Article

Plasmonics

, Volume 2, Issue 4, pp 173-183

Gold Nanoparticle Based FRET for DNA Detection

  • Paresh Chandra RayAffiliated withDepartment of Chemistry, Jackson State University Email author 
  • , Gopala Krishna DarbhaAffiliated withDepartment of Chemistry, Jackson State University
  • , Anandhi RayAffiliated withDepartment of Chemistry, Jackson State University
  • , Joshua WalkerAffiliated withDepartment of Chemistry, Jackson State University
  • , William HardyAffiliated withDepartment of Chemistry, Jackson State University

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Abstract

The nanoscience revolution that sprouted throughout the 1990s is having great impact in current and future DNA detection technology around the world. In this review, we report our recent progress on gold nanoparticle based fluorescence resonance energy transfer assay to monitor DNA hybridization as well as the cleavage of DNA by nucleases. We tried to discuss a reasonable account of the science and the important fundamental work carried out in this area. We also report the development of a compact, highly specific, inexpensive and user-friendly optical fiber laser-induced fluorescence sensor based on fluorescence quenching by nanoparticles to detect single-strand DNA hybridization at femtomolar level.

Keywords

Gold nanoparticle FRET DNA detection Sensor