Articles

Science China Chemistry

, Volume 55, Issue 10, pp 2134-2153

Synthesis and biological activities of thio-triazole derivatives as novel potential antibacterial and antifungal agents

  • QingPeng WangAffiliated withSchool of Chemistry and Chemical Engineering, Southwest University
  • , JingQing ZhangAffiliated withChongqing Key Laboratory of Biochemical & Molecular Pharmacology, Medicine Engineering Research Center, Chongqing Medical University
  • , Guri L. V. DamuAffiliated withSchool of Chemistry and Chemical Engineering, Southwest University
  • , Kun WanAffiliated withSchool of Chemistry and Chemical Engineering, Southwest University
  • , HuiZhen ZhangAffiliated withSchool of Chemistry and Chemical Engineering, Southwest University
  • , ChengHe ZhouAffiliated withSchool of Chemistry and Chemical Engineering, Southwest University Email author 

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Abstract

A series of novel thio-triazole derivatives including thiols, thioethers and thiones as well as some corresponding triazolium compounds were conveniently and efficiently synthesized from commercially available halobenzyl halides and thiosemicarbazide. All the new compounds were characterized by 1H NMR, 13C NMR, FTIR, MS and HRMS spectra. Their antibacterial and antifungal activities in vitro were evaluated against four Gram-positive bacteria, four Gram-negative bacteria and two fungi by two-fold serial dilution technique. The preliminary bioassay indicated that some prepared triazoles exhibited effective antibacterial and antifungal activities. Especially, 3,4-dichlorobenzyl triazole-thione and its triazolium derivatives displayed the most potent activities against all the tested strains.

Keywords

triazole triazolium antibacterial antifungal cyclization