Reviews Special Topic · In Honor of the 80th Birthday of Professor Ronald Breslow

Science China Chemistry

, Volume 54, Issue 11, pp 1670-1687

First online:

Transition metal-catalyzed decarboxylative cross-coupling reactions

  • Rui ShangAffiliated withKey Laboratory of Bioorganic Phosphorus Chemistry & Chemical Biology (Ministry of Education); Department of Chemistry, Tsinghua University
  • , Lei LiuAffiliated withKey Laboratory of Bioorganic Phosphorus Chemistry & Chemical Biology (Ministry of Education); Department of Chemistry, Tsinghua UniversityState Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences Email author 

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Abstract

Transition metal-catalyzed decarboxylative cross-coupling reactions have recently emerged as a new and important category of organic transformations that find versatile applications in the construction of carbon-carbon and carbon-heteroatom bonds. The use of relatively cheap and stable carboxylic acids to replace organometallic reagents enables the decarboxylative cross-coupling reactions to proceed with good selectivities and functional group tolerance. In the present review we summarize the various types of decarboxylative cross-coupling reactions catalyzed by different transition metal complexes. The scope and applications of these reactions are described. The challenges and opportunities in the field are discussed.

Keywords

decarboxylation cross-coupling reaction transition metal catalysis organic synthesis