, Volume 54, Issue 11, pp 1670-1687
Date: 12 Oct 2011

Transition metal-catalyzed decarboxylative cross-coupling reactions

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Abstract

Transition metal-catalyzed decarboxylative cross-coupling reactions have recently emerged as a new and important category of organic transformations that find versatile applications in the construction of carbon-carbon and carbon-heteroatom bonds. The use of relatively cheap and stable carboxylic acids to replace organometallic reagents enables the decarboxylative cross-coupling reactions to proceed with good selectivities and functional group tolerance. In the present review we summarize the various types of decarboxylative cross-coupling reactions catalyzed by different transition metal complexes. The scope and applications of these reactions are described. The challenges and opportunities in the field are discussed.

Dedicated to Prof. Ronald Breslow on the occasion of his 80th birthday