Science China Chemistry

, Volume 54, Issue 11, pp 1670–1687

Transition metal-catalyzed decarboxylative cross-coupling reactions

Reviews Special Topic · In Honor of the 80th Birthday of Professor Ronald Breslow

DOI: 10.1007/s11426-011-4381-0

Cite this article as:
Shang, R. & Liu, L. Sci. China Chem. (2011) 54: 1670. doi:10.1007/s11426-011-4381-0


Transition metal-catalyzed decarboxylative cross-coupling reactions have recently emerged as a new and important category of organic transformations that find versatile applications in the construction of carbon-carbon and carbon-heteroatom bonds. The use of relatively cheap and stable carboxylic acids to replace organometallic reagents enables the decarboxylative cross-coupling reactions to proceed with good selectivities and functional group tolerance. In the present review we summarize the various types of decarboxylative cross-coupling reactions catalyzed by different transition metal complexes. The scope and applications of these reactions are described. The challenges and opportunities in the field are discussed.


decarboxylationcross-coupling reactiontransition metalcatalysisorganic synthesis

Copyright information

© Science China Press and Springer-Verlag Berlin Heidelberg 2011

Authors and Affiliations

  1. 1.Key Laboratory of Bioorganic Phosphorus Chemistry & Chemical Biology (Ministry of Education); Department of ChemistryTsinghua UniversityBeijingChina
  2. 2.State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic ChemistryChinese Academy of SciencesShanghaiChina