Letter to the Editor
To the Editor,
We read the study by Yang et al. entitled “In Vitro Elution Characteristics of Vancomycin in a Composite Calcium Phosphate/Calcium Sulfate Bone Substitute” with great interest . We want to congratulate the authors for their great effort and valuable study. However, we felt that there are few queries which the authors could clarify.
The authors reported mixing the biphasic CaP/CaS powder with a radiopaque iohexol solution ahead to mixing the composite with vancomycin, and we are interested to know the reason for this step, especially that when calcium sulfate hemihydrate comes in contact with the iohexol solution, it is ionized and recrystallizes into calcium sulfate dihydrate. We are wondering if the authors took into consideration the potential effect of such addition on the experiment and tried to add a control group.
We are interested to know if the authors noticed any changes in the setting time for the composite with the changing in the antibiotic concentration
- Yang X, Osagie L, Bostrom MP. In Vitro Elution Characteristics of Vancomycin in a Composite Calcium Phosphate/Calcium Sulfate Bone Substitute. HSS J. 2012; 8(2): 129‐132.
- Gitelis S, Brebach GT. The treatment of chronic osteomyelitis with a biodegradable antibiotic-impregnated implant. J Orthop Surg (Hong Kong). 2002; 10(1): 53-60.
- Guo H, Wei J, Liu CS. Development of a degradable cement of calcium phosphate and calcium sulfate composite for bone reconstruction. Biomed Mater. 2006; 1(4): 193-197. doi:10.1088/1748-6041/1/4/003. CrossRef
- Hu G, Xiao L, Fu H, Bi D, Ma H, Tong P. Study on injectable and degradable cement of calcium sulphate and calcium phosphate for bone repair. J Mater Sci: Mater Med. 2010; 21(2): 627-634. doi:10.1007/s10856-009-3885-z.
- Letter to the Editor
HSS Journal ®
Volume 10, Issue 1 , p 98
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