February 2010, Volume 6, Issue 1, pp 79-84,
Open Access This content is freely available online to anyone, anywhere at any time.
Date: 10 Sep 2009
Deleterious Effects of Intermittent Recombinant Parathyroid Hormone on Cartilage Formation in a Rabbit Microfracture Model: a Preliminary Study
Intermittent parathyroid hormone administration can enhance fracture healing in an animal model. Despite the success of exogenous parathyroid hormone on fracture healing and spine fusion, few studies have examined the role of parathyroid hormone on cartilage formation. We determined the effects of intermittent parathyroid hormone on cartilage formation in a rabbit microfracture model of cartilage regeneration. Twelve rabbits were divided into three equal groups: (1) microfracture alone, (2) microfracture + parathyroid hormone daily for 7 days, and (3) microfracture + parathyroid hormone for 28 days. Nonoperated contralateral knees were used as controls. The animals were sacrificed at 3 months and gross and histologic analysis was performed. The microfracture alone group demonstrated the most healing on gross and histologic analysis. Treatment with either 1 or 4 weeks of parathyroid hormone inhibited cartilage formation. Although discouraging from a cartilage repair point of view, this study suggests that the role parathyroid hormone administration has in clinical fracture healing must be examined carefully. Although parathyroid hormone is beneficial to promote healing in spine fusion and midshaft fractures, its deleterious effects on cartilage formation suggests that it may have adverse effects on the outcomes of periarticular fractures such as tibial plateau injuries that require cartilage healing for a successful clinical outcome.
Each author certifies that he or she has no commercial associations (e.g., consultancies, stock ownership, equity interest, patent/licensing arrangements, etc.) that might pose a conflict of interest in connection with the submitted article.
Each author certifies that his or her institution has approved the animal protocol for this investigation and that all investigations were conducted in conformity with ethical principles of research.
Outerbridge RE. The etiology of chondromalacia patellae. J. Bone Joint Surg. Br. 1961; 43B: 752–757.
Outerbridge RE, Dunlop JA, The etiology of chondromalacia patellae. Clin. Orthop. Rel. Res. 1975; 110: 177–196.CrossRef
Gill TJ, The treatment of articular cartilage defects using microfracture and debridement. Am. J. Knee Surg. 2000; 13: 33–40.PubMed
Steadman JR, Miller BS, Karas SG, et al. The microfracture technique in the treatment of full-thickness chondral lesions of the knee in National Football League players. J. Knee Surg. 2003; 16: 83–86.PubMed
Williams RJ, 3rd, Harnly HW. Microfracture: indications, technique, and results. Instr. Course Lect. 2007; 56: 419–428PubMed
Pineda S, Pollack A, Stevenson S, et al. A semiquantitative scale for histologic grading of articular cartilage repair. Acta Anat. (Basel). 1992; 143: 335–340.CrossRef
Alkhiary YM, Gerstenfeld LC, Krall E, et al. Enhancement of experimental fracture-healing by systemic administration of recombinant human parathyroid hormone (PTH 1–34). J. Bone Joint Surg. Am. 2005; 7: 731–741.CrossRef
- Deleterious Effects of Intermittent Recombinant Parathyroid Hormone on Cartilage Formation in a Rabbit Microfracture Model: a Preliminary Study
- Open Access
- Available under Open Access This content is freely available online to anyone, anywhere at any time.
Volume 6, Issue 1 , pp 79-84
- Cover Date
- Print ISSN
- Online ISSN
- Additional Links
- parathyroid hormone
- Author Affiliations
- 1. Hospital for Special Surgery, 535 East 70th Street, New York, NY, 10021, USA
- 2. Department of Orthopaedic Surgery, University of California, San Francisco, 500 Parnassus Avenue, Millberry Union 320, San Francisco, CA, 94143, USA