, Volume 5, Issue 2, pp 200-203
Date: 18 Aug 2009

Hospital for Special Surgery 2009 Resident and Fellow Research Presentations Award-Winning Abstracts

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The Lewis Clark Wagner Award Recognizes Outstanding Resident’s Paper

Recipient: Lawrence V. Gulotta, MD

Stem Cells Genetically Modified with the Developmental Gene MT1-MMP Improve Regeneration of the Tendon-to-Bone Insertion Site

Lawrence V. Gulotta, M.D; David Kovacevic, MD; John R. Ehteshami, MD; Scott Montgomery, BS; Jonathan D. Packer, MD; Scott A. Rodeo, MD.

Introduction

Rotator cuffs heal through a scar tissue interface following repair that makes them prone to failure. MT1-MMP is upregulated during embryogenesis in areas that develop into tendon–bone insertion sites. The purpose of this study was to determine if the application of mesenchymal stem cells (MSCs) transduced with Ad-MT1-MMP could improve regeneration of the tendon–bone insertion site in a rotator cuff repair model. Our hypothesis was that pluripotent stem cells in the presence of the developmental signal from MT1-MMP would drive the healing process towards regeneration and away from scar formation.

Methods

In this IACUC-ap ...