HSS Journal

, Volume 5, Issue 1, pp 49-50

First online:

SH3BP2 is a Critical Regulator of Macrophage and Osteoclast Response to M-CSF and RANKL Stimulation

  • Mark S. McMahonAffiliated withDepartment of Orthopedic Surgery, Beth Israel Deaconess Medical CenterDepartment of Developmental Biology, Harvard School of Dental Medicine Email author 
  • , Yasuyoshi UekiAffiliated withDepartment of Developmental Biology, Harvard School of Dental Medicine

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The protein Src homology 3 domain-binding protein 2 (SH3BP2) is a regulator of tumor necrosis factor (TNF)-alpha generation in macrophages and of osteoclast differentiation. SH3BP2 regulates bone marrow monocyte responses to macrophage and osteoclast differentiation signals downstream of the receptors for macrophage colony-stimulating factor and receptor activator of nuclear factor kappaB ligand. SH3BP2 is a potential target for the development of novel anti-TNF-alpha therapeutic interventions as well as a target for suppression of osteoclastogenesis.


SH3BP2 macrophage osteoclast M-CSF RANKL