Forensic Toxicology

, Volume 32, Issue 2, pp 266–281

Chemical analysis of a benzofuran derivative, 2-(2-ethylaminopropyl)benzofuran (2-EAPB), eight synthetic cannabinoids, five cathinone derivatives, and five other designer drugs newly detected in illegal products

  • Nahoko Uchiyama
  • Yoshihiko Shimokawa
  • Maiko Kawamura
  • Ruri Kikura-Hanajiri
  • Takashi Hakamatsuka
Original Article

DOI: 10.1007/s11419-014-0238-5

Cite this article as:
Uchiyama, N., Shimokawa, Y., Kawamura, M. et al. Forensic Toxicol (2014) 32: 266. doi:10.1007/s11419-014-0238-5

Abstract

From November 2013 to May 2014, 19 newly distributed designer drugs were identified in 104 products in our ongoing survey of illegal products in Japan. The identified compounds included 8 synthetic cannabinoids, FUB-PB-22 (1), 5-fluoro-NNEI indazole analog (5-fluoro-MN-18, 2), AM-2201 indazole analog (THJ-2201, 3), XLR-12 (4), 5-fluoro-AB-PINACA (5), 5-chloro-AB-PINACA (6), AB-CHMINACA (7), and 5-fluoro-AMB (8); 5 cathinone derivatives, DL-4662 (9), α-PHP (10), 4-methoxy-α-POP (11), 4-methoxy-α-PHPP (12), and 4-fluoro-α-PHPP (13); and 6 other substances, namely, the benzofuran derivative 2-(2-ethylaminopropyl)benzofuran (2-EAPB, 14), nitracaine (15), diclofensine (16), diphenidine (17), 1-benzylpiperidine (18), and acetylfentanyl (19). To our knowledge, this is the first report on the chemical properties of compounds 911 and 14. A total of 33 designer drugs, including compounds 119, were detected in the 104 illegal products, in 60 different combination patterns. The numbers of detected compounds per product ranged from 1 to 7. In addition, several products contained three different types of compounds, such as synthetic cannabinoids, cathinone derivatives, and phenethylamine derivatives per product. It is apparent that the types of compounds emerging as illegal products are becoming more diverse, as are their combinations.

Keywords

2-(2-Ethylaminopropyl)benzofuran (2-EAPB) Synthetic cannabinoid Cathinone derivative Diclofensine Diphenidine Nitracaine 

Supplementary material

11419_2014_238_MOESM1_ESM.pdf (204 kb)
Supplementary material 1 (PDF 204 kb)

Copyright information

© Japanese Association of Forensic Toxicology and Springer Japan 2014

Authors and Affiliations

  • Nahoko Uchiyama
    • 1
  • Yoshihiko Shimokawa
    • 1
  • Maiko Kawamura
    • 1
  • Ruri Kikura-Hanajiri
    • 1
  • Takashi Hakamatsuka
    • 1
  1. 1.Division of Pharmacognosy, Phytochemistry and NarcoticsNational Institute of Health SciencesTokyoJapan