Forensic Toxicology

, Volume 31, Issue 2, pp 292–300

Mass spectrometric differentiation of the isomers of mono-methoxyethylamphetamines and mono-methoxydimethylamphetamines by GC–EI–MS–MS

  • Kei Zaitsu
  • Haruhiko Miyagawa
  • Yuki Sakamoto
  • Shuntaro Matsuta
  • Kento Tsuboi
  • Hiroshi Nishioka
  • Munehiro Katagi
  • Takako Sato
  • Michiaki Tatsuno
  • Hitoshi Tsuchihashi
  • Koichi Suzuki
  • Akira Ishii
Original Article

DOI: 10.1007/s11419-013-0193-6

Cite this article as:
Zaitsu, K., Miyagawa, H., Sakamoto, Y. et al. Forensic Toxicol (2013) 31: 292. doi:10.1007/s11419-013-0193-6

Abstract

Mass spectrometric differentiation of the six isomers of mono-methoxyethylamphetamines (MeO-EAs) and mono-methoxydimethylamphetamines (MeO-DMAs) by gas chromatography–electron ionization–tandem mass spectrometry (GC–EI–MS–MS) was investigated. Based on their EI-mass spectra, the fragment ions at m/z 121 and 72 were selected as precursor ions for their regioisomeric and structurally isomeric differentiation, respectively. Collision-induced dissociation provides intensity differences in product ions among the isomers, enabling mass spectrometric differentiation of the isomers. Furthermore, high reproducibility of the product ion spectra at the optimized collision energy was confirmed, demonstrating the reliability of the method. To our knowledge, this is the first report on mass spectrometric differentiation of the six isomers of MeO-EAs and MeO-DMAs by GC–EI–MS–MS. Isomeric differentiation by GC–EI–MS–MS has a high potential to discriminate isomers of newly encountered designer drugs, making GC–MS–MS a powerful tool in the forensic toxicology field.

Keywords

GC–EI–MS–MS Isomeric differentiation Methoxyethylamphetamine Methoxydimethylamphetamine Designer drugs 

Copyright information

© Japanese Association of Forensic Toxicology and Springer Japan 2013

Authors and Affiliations

  • Kei Zaitsu
    • 1
  • Haruhiko Miyagawa
    • 2
  • Yuki Sakamoto
    • 2
  • Shuntaro Matsuta
    • 3
  • Kento Tsuboi
    • 4
  • Hiroshi Nishioka
    • 3
  • Munehiro Katagi
    • 3
  • Takako Sato
    • 4
  • Michiaki Tatsuno
    • 3
  • Hitoshi Tsuchihashi
    • 4
  • Koichi Suzuki
    • 4
  • Akira Ishii
    • 1
  1. 1.Department of Legal Medicine and BioethicsNagoya University Graduate School of MedicineNagoyaJapan
  2. 2.Shimadzu CorporationKyotoJapan
  3. 3.Forensic Science Laboratory, Osaka Prefectural Police HeadquartersOsakaJapan
  4. 4.Department of Legal MedicineOsaka Medical CollegeTakatsukiJapan