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The cytotoxic and tyrosine kinase inhibitory properties of C21 steroids and iridoids from the tubers of Alocasia cucullata

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Abstract

Ten steroids and iridoids were isolated from the tubers of Alocasia cucullata (Lour.) G. Don. Among them, alocasgenin A (1) and alocasgenoside B–C (2–3) were new compounds and the aglycone of compound 1, obtained from the acid hydrolysis of 1, was named alocasgenol (1a). Also, for the first time, tenacigenin B (4), 17β-tenacigenin-B (5), 3-O-6-deoxy-3-O-methyl-β-d-allopyranosyl-(1→4)-β-d-oleandropyranosyl-tenacigenin C (6), marsdenoside A–B (7–8) and tenacigenoside A–B (9–10) were isolated from the genus Alocasia. The chemical structures were elucidated by the extensive analysis of spectral data and compared with the literature. By evaluation of the cytotoxic and tyrosine kinase inhibition, compounds 1–10, 1a and compound 2 showed significant growth inhibition against two tumour cell lines, MGC-803 and HT-29, while compounds 1, 1a, 3, 6 and 8 presented moderate inhibition. Furthermore, compound 2 had the inhibitory property against the enzyme activity biochemically.

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Acknowledgements

This study was supported by grant A1-20140371 from Project of Shanghai Education Commission within budget.

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    Authors and Affiliations

    1. Department of Medical Oncology, Fudan University Shanghai Cancer Center, Fudan University, Shanghai, People’s Republic of China

      Wei Peng & ZhiYu Chen

    2. Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, People’s Republic of China

      Wei Peng & ZhiYu Chen

    3. Engineering Research Center of Modern Preparation Technology of TCM, Ministry of Education, Shanghai University of Traditional Chinese Medicine, Room 1107, No. 1200 Cai Lun Road, Pudong District, Shanghai, People’s Republic of China

      Shuang Liang, JiaLiang Hu & Xiangwei Zheng

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    1. Wei Peng
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    2. Shuang Liang
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    3. JiaLiang Hu
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    5. Xiangwei Zheng
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    Corresponding author

    Correspondence to Xiangwei Zheng.

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    W. Peng, S. Liang, Z. Chen and X. Zheng contributed equally to this work.

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    Peng, W., Liang, S., Hu, J. et al. The cytotoxic and tyrosine kinase inhibitory properties of C21 steroids and iridoids from the tubers of Alocasia cucullata . J Nat Med 70, 602–609 (2016). https://doi.org/10.1007/s11418-016-0982-4

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