New Generations: Sequencing Machines and Their Computational Challenges
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New generation sequencing systems are changing how molecular biology is practiced. The widely promoted $1000 genome will be a reality with attendant changes for healthcare, including personalized medicine. More broadly the genomes of many new organisms with large samplings from populations will be commonplace. What is less appreciated is the explosive demands on computation, both for CPU cycles and storage as well as the need for new computational methods. In this article we will survey some of these developments and demands.
- New Generations: Sequencing Machines and Their Computational Challenges
Journal of Computer Science and Technology
Volume 25, Issue 1 , pp 3-9
- Cover Date
- Print ISSN
- Online ISSN
- Springer US
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- genome sequencing
- new generation sequencing
- read mapping
- optical mapping
- sequence assembly
- Eulerian graphs
- Industry Sectors
- Author Affiliations
- 1. Laboratory for Molecular and Computational Genomics, Department of Chemistry and Laboratory of Genetics, University of Wisconsin-Madiso, Wisconsin, WI, 53706, U.S.A.
- 2. Department of Biological Sciences, University of Southern California, Los Angeles, CA, 90089-2910, U.S.A.
- 3. Department of Automation, Tsinghua University, Beijing, 100084, China