, Volume 25, Issue 1, pp 3-9

New Generations: Sequencing Machines and Their Computational Challenges

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Abstract

New generation sequencing systems are changing how molecular biology is practiced. The widely promoted $1000 genome will be a reality with attendant changes for healthcare, including personalized medicine. More broadly the genomes of many new organisms with large samplings from populations will be commonplace. What is less appreciated is the explosive demands on computation, both for CPU cycles and storage as well as the need for new computational methods. In this article we will survey some of these developments and demands.

This work is supported by NIH under Grant No. R01 HG000225 (DCS) and NSF of USA under Grant No. DBI-0501818 (DCS).