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DHEA, DHEA-S and cortisol responses to acute exercise in older adults in relation to exercise training status and sex

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Abstract

The aim of the present study was to investigate resting measures of dehydroepiandrosterone (DHEA), dehydroepiandrosterone sulphate (DHEA-S) and cortisol, and the response and recovery of these hormones to acute exercise, in male and female older adults of different exercise training status. Participants were 49 community-dwelling older adults (23 females) aged between 60 and 77 years who were either sedentary (n = 14), moderately active (n = 14) or endurance trained (n = 21). Participants undertook an acute bout of exercise in the form of an incremental submaximal treadmill test. The exercise lasted on average 23 min 49 s (SD = 2 min 8 s) and participants reached 76.5% (SD = 5.44) of the predicted maximal heart rate. Blood samples were collected prior to exercise, immediately, and 1 h post-exercise. DHEA levels significantly increased immediately post-exercise; however, DHEA-S levels only significantly increased in females. Cortisol significantly decreased immediately post-exercise and 1 h post-exercise compared to pre-exercise. There were no significant differences in resting hormone levels or hormonal responses to exercise between training status groups. The findings suggest that exercise can stimulate DHEA production in older adults and that hormonal responses to exercise differ between male and female older adults.

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References

  • Abbasi A, Duthie EH, Sheldahl L, Wilson C, Sasse E, Rudman I, Mattson DE (1998) Association of dehydroepiandrosterone sulphate, body composition and physical fitness in independent community-dwelling older men and women. J Am Geriatr Soc 46:263–273

    Google Scholar 

  • Ainsworth BE, Haskell WL, Whitt CM, Irwin ML, Swartz AN, Strath SJ, O'Brien WL (2000) Compendium of physical activities: an update of activity codes and MET intensities. Med Sci Sports Exerc 32:S498–S504

    Article  PubMed  CAS  Google Scholar 

  • Aldred S, Rohalu M, Edwards K, Burns V (2009) Altered DHEA and DHEAS response to exercise in healthy older adults. J Ageing Phys Act 17:77–88

    Google Scholar 

  • Anderson NB, Armstead CA (1995) Toward understanding the association of socio-economic status and health—a new challenge for the biopsychosocial approach. Psychosom Med 57:213–225

    PubMed  CAS  Google Scholar 

  • Arai MH, Deuarte AJ, Natale VM (2006) The effects of long-term endurance training on the immune and endocrine systems of elderly men: the role of cytokines and anabolic hormones. Immun Ageing 25:3–9

    Google Scholar 

  • Belanger A, Candas B, Dupont A, Cusan L, Diamond P, Gomez JL, Labrie F (1994) Changes in serum concentrations of conjugated and unconjugated steriods in 40-year-old to 80-year-old men. J Clin Endocrinol Met 79:1086–1090

    Article  CAS  Google Scholar 

  • Bishop NC (2006) Acute exercise and aquired immune function. In: Glesson M (ed) Immune function in sport and exercise. Churchill Livingstone Elsevier, London

    Google Scholar 

  • Bonnefoy M, Kostka T, Patricot MC, Berthouze SE, Mathian B, Lacour JR (1998) Physical activity and dehydroepiandrosterone sulphate, insulin-like growth factor and testosterone in healthy active elderly. Age Ageing 1998:745–751

    Article  Google Scholar 

  • Bonnefoy M, Patricot MC, Lacour JR, Rahmani A, Berthouze SE, Kostka T (2002) Relation between physical activity, muscle function and IGF-1, testosterone and DHEAS concentrations in the elderly. Rev Med Interne 23:819–827

    Article  PubMed  CAS  Google Scholar 

  • Borg GA (1998) Borg's ratings of percieved exhertion and pain scales. Human Kinetics, Champaign

    Google Scholar 

  • Buford TW, Willoughby DS (2005) Impact of DHEA(S) and cortisol on immune function in ageing: a brief review. Appl Physiol Nutr Metab 33:429–433

    Article  Google Scholar 

  • Butcher SK, Killampalli V, Lascelles D, Wang K, Alpar EK, Lord JM (2005) Raised cortisol:DHEAS ratios in the elderly after injury: potential impact upon neutrophil function and immunity. Aging Cell 4:319–324

    Article  PubMed  CAS  Google Scholar 

  • Cadore EL, Lhullier FL, Brentano MA, da Silva RF, Ambrosini MB, Spinelli R, Silva RF, Kruel LF (2008) Hormonal responses to resistance exercise in long term trained and untrained middle-aged men. J Strength Cond Res 22:1617–1627

    Article  PubMed  Google Scholar 

  • Chahal HS, Drake WM (2007) The endocrine system and ageing. J Pathol 211:173–180

    Article  PubMed  CAS  Google Scholar 

  • Copeland JL, Consitt LA, Tremblay MS (2002) Hormal responses to endurance and resistance exercise in females aged 19–69 years. J Gerontol A Biol Sci Med Sci 57:158–165

    Article  Google Scholar 

  • Cumming DC, Brunsting LA, Strich G, Reis AL, Rebar W (1986) Reproductive hormone increases in response to acute exercise in men. Med Sci Sports Exerc 18:369–373

    Article  PubMed  CAS  Google Scholar 

  • de Gonzalo-Calvo D, Fernandez-Garcia B, de Luxan-Delago B, Rodriguez-Gonzalez S, Garcia-Marcia M, Suarez FM, Solano JJ, Rodriguez-Colunga MJ, Coto-Montes A (2011) Long-term training induces a healthy inflammatory and endocrine emergent biomarker profile in elderly men. Age (Dordr) (in press)

  • Deuschle M, Gotthardt U, Schweiger U, Weber B, Körner A, Schmider J, Standhardt H, Lammers C-H, Heuser I (1997) With aging in humans the activity of the hypothalamus–pituitary–adrenal system increases and its diurnal amplitude flattens. Life Sci 61:2239–2246

    Article  PubMed  CAS  Google Scholar 

  • Ford G, Ecob R, Hunt K, Macintyre S, West P (1994) Patterns of class inequality in health through the life span: class gradients at 15, 35 and 55 years in the west of Scotland. Soc Sci Med 39:1037–1050

    Article  PubMed  CAS  Google Scholar 

  • Giannopoulou L, Carhart R, Sauro LM, Kanaley JA (2003) Adrenocortical responses to submaximal exercise in postmenopausal black and white women. Metabolism 52:1643–1647

    Article  PubMed  CAS  Google Scholar 

  • Häkkinen K, Parkarinen A, Kraemer WJ, Newton RU, Alen M (2000) Basal concentrations and acute responses of serum hormones and strength development during heavy resistance training in middle-aged and elderly men and woman. J Gerontol A Biol Sci Med Sci 55:B95–B105

    Article  PubMed  Google Scholar 

  • Hersey WCr, Graves JE, Pollock ML, Gingerich R, Shireman RB, Heath GW, Spierto F, McCole SD, Hagberg JM (1994) Endurance exercise training improves body composition and plasma insulin responses in 70- to 79-year old men and women. Metabolism 43:847–854

    Article  PubMed  CAS  Google Scholar 

  • Hugget DL, Connelly DM, Overend TJ (2005) Maximal aerobic capacity testing of older adults: a critical review. J Gerontol A Biol Sci Med Sci 60:57–66

    Article  Google Scholar 

  • Johnson LG, Kraemer RR, Haltom R, Kraemer GR, Gaines HE, Castracane VD (1997) Effects of estrogen replacement therapy on dehydroepiandrosterone, dehydroepiandrosterone sulphate, and cortisol responses to exercise in postmenopausal women. Fertil Steril 68:836–843

    Article  PubMed  CAS  Google Scholar 

  • Keizer HA, Kuipers H, de Haan J, Janssen GM, Beckers E, Habets L, van Kranenberg G, Geurten P (1987) Effect of a 3 month endurance training program on metabolic and multiple hormonal responses to exercise. Int J Sports Med 8:154–160

    Article  PubMed  Google Scholar 

  • Keizer H, Janssen GM, Menheere P, Kranenberg G (1989) Changes in basal plasma testosterone, cortisol, and dehydroepiandrosterone sulphate in previously untrained males and females preparing for a marathon. Int J Sports Med 10:S139–S145

    Article  PubMed  Google Scholar 

  • Kemmler W, Wildt L, Engelke K, Pintag R, Pavel M, Bracher B, Weineck J, Kalender W (2003) Acute hormonal responses of a high impact physical exercise session in early postmenopausal women. Eur J Appl Physiol 90:199–200

    Article  PubMed  CAS  Google Scholar 

  • Kostka T, Pariante CM, Berthouze SE, Lacour JR, Bonnefoy M (2002) Influence of 6 month changes in habitual physical activity on dehydroepiandrosterone sulphate in elderly subjects. Biol Sport 19:33–41

    Google Scholar 

  • Labrie F, Belanger A, Cusan L, Gomez JL, Candas B (1997) Marked decline in serum concentrations of adrenal C19 sex steroid precursors and conjugated androgen metabolites during aging. J Clin Endocrinol Met 82:2396–2402

    Article  CAS  Google Scholar 

  • Marmot MG, Smith GD, Stansfeld S, Patel C, North F, Head J, White I, Brunner E, Feeney A (1991) Health inequalities amoung British civil servants: the Whitehall II study. Lancet 337:1387–1399

    Article  PubMed  CAS  Google Scholar 

  • McArdle WD, Katch FI, Katch VL (2001) Exercise physiology: energy, nutrition and human performance. Lippincott Williams & Wilkins, Baltimore

    Google Scholar 

  • Nelson ME, Rejeski WJ, Blair SN, Duncan PW, Judge JO, King AC (2007) Physical acivity and public health in older adults. Circulation 116:1094

    Article  PubMed  Google Scholar 

  • Nieman DC, Henson DA, Gusewitch G, Warren BJ, Dotson RC, Butterworth DE, Nehlsencannarella SL (1993) Physical activity and immune function in elderly women. Med Sci Sports Exerc 25:823–831

    Article  PubMed  CAS  Google Scholar 

  • Orentreich N, Brind JL, Vogelman JH, Andres R, Baldwin H (1992) Long term longitudinal measurements of plasma dehydroepiandrosterone sulphate in normal man. J Clin Endocrinol Met 75:1002–1004

    Article  CAS  Google Scholar 

  • Pedersen BK, Hoffman-Goetz L (2000) Exercise and the immune system: regulation, integration, and adaptation. Physiol Rev 80:1055–1081

    PubMed  CAS  Google Scholar 

  • Phillips AC, Burns VE, Lord JM (2007) Stress and exercise: getting the balance right for aging immunity. Exerc Sport Sci Rev 35:35–39

    Article  PubMed  Google Scholar 

  • Ponjee GA, De Rooy HA, Vader HL (1994) Androgen turnover during marathon running. Med Sci Sports Exerc 26:1274–1277

    Article  PubMed  CAS  Google Scholar 

  • Ravaglia G, Forti P, Maioli F, Pratelli L, Vettori C, Bastagli L, Mariani E, Facchini A, Cucinotta D (2001) Regular moderate intensity physical activity and blood concentrations of endogenous anabolic hormones and thyroid hormones in aging men. Mech Ageing Dev 122:191–203

    Article  PubMed  CAS  Google Scholar 

  • Shinkai S, Kohno H, Kimura K, Komura T, Asai H, Inai R, Oka K, Kurokawa Y, Shephard RJ (1995) Physical activity and immune senescence in men. Med Sci Sports Exerc 27:1516–1526

    Article  PubMed  CAS  Google Scholar 

  • Tanka H, Monahan KD, Seals DR (2001) Age predicted maximal heart rate revisited. J Am Coll Cardiol 37:153–156

    Article  Google Scholar 

  • Tharrett SJ, Peterson JA (1997) ACSM's health/fitness facility standards and guidelines. Human Kinetics, Champaign

    Google Scholar 

  • Tissandier O, Peres G, Fiet J, Piette F (2001) Testosterone, dehydroepiandrosterone, insulin-like growth factor 1, and insulin in sedentary and physically trained aged men. Eur J Appl Physiol 85:177–184

    Article  PubMed  CAS  Google Scholar 

  • Traustadottir T, Bosch PR, Cantu T, Matt KS (2004) Hypothalamic–pituitary–adrenal axis response and recovery from high-intensity exercise in women: effects of aging and fitness. J Clin Endocrinol Met 89:3248–3254

    Article  CAS  Google Scholar 

  • Tremblay MS, Copeland JL, Van Helder W (2004) Effect of training status and exercise mode on endogenous steroid hormones in men. J Appl Physiol 96:531–539

    Article  PubMed  CAS  Google Scholar 

  • VanCauter E, Leproult R, Kupfer DJ (1996) Effects of gender and age on the levels and circadian rhythmicity of plasma cortisol. J Clin Endocrinol Met 81:2468–2473

    Article  CAS  Google Scholar 

  • Velardo A, Pantaleoni M, Valerio L, Barini A, Marrama P (1991) Influence of exercise on dehydroepiandrosterone sulphate and delta 4-androsterone plasma levels in man. Exp Clin Endocrinol 97:99–101

    Article  PubMed  CAS  Google Scholar 

  • Walston J, Hadley EC, Ferrucci L, Guralnik JM, Newman AB, Studenski SA, Ershler WB, Harris T, Fried LP (2006) Research agenda for frailty in older adults: toward a better understanding of physiology and etiology: summary from the American Geriatrics Society/National Institute on Aging Research Conference on Frailty in Older Adults. J Am Geriatr Soc 54:991–1001

    Article  PubMed  Google Scholar 

  • Zigmond AS, Snaith RP (1983) The hospital anxiety and depression scale. Acta Psychiatr Scand 67:361–370

    Article  PubMed  CAS  Google Scholar 

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Acknowledgments

The authors would like to thank the participants and Siobhan Forrest, Deborah Shearring, Alison Wood, Patrick Dawkes, Rosa James-Watling, Ruth Mackay, Emma Dodd and Lucy Dowsett for their help with data collection.

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Authors and Affiliations

  1. School of Sport and Exercise Sciences, University of Birmingham, Birmingham, West Midlands, England, UK, B15 2TT

    Jennifer L. J. Heaney, Douglas Carroll & Anna C. Phillips

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  1. Jennifer L. J. Heaney
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  2. Douglas Carroll
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  3. Anna C. Phillips
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Correspondence to Jennifer L. J. Heaney.

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Heaney, J.L.J., Carroll, D. & Phillips, A.C. DHEA, DHEA-S and cortisol responses to acute exercise in older adults in relation to exercise training status and sex. AGE 35, 395–405 (2013). https://doi.org/10.1007/s11357-011-9345-y

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  • DOI: https://doi.org/10.1007/s11357-011-9345-y

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