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Angiotensin-converting enzyme (ACE) genotypes and disability in hospitalized older patients

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Abstract

The association between angiotensin-converting enzyme (ACE) genotypes and functional decline in older adults remains controversial. To assess if ACE gene variations influences functional abilities at older age, the present study explored the association between the common ACE insertion/deletion (I/D) polymorphism and disability measured with activities of daily living (ADL) in hospitalized older patients. We analyzed the frequency of the ACE genotypes (I/I, I/D, and D/D) in a population of 2,128 hospitalized older patients divided according to presence or absence of ADL disability. Logistic regression analysis adjusted for possible confounding factors, identified an association between the I/I genotype with ADL disability (OR = 1.54, 95% CI 1.04–2.29). This association was significant in men (OR = 2.01, 95% CI 1.07–3.78), but not in women (OR = 1.36, 95% CI 0.82–2.25). These results suggested a possible role of the ACE polymorphism as a genetic marker for ADL disability in hospitalized older patients.

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Acknowledgments

This work was completely supported from “Ministero della Salute”, IRCCS Research Program, Ricerca Corrente 2009–2011, Linea n. 2 “Malattie complesse”.

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Authors and Affiliations

  1. Department of Medical Sciences, Geriatric Unit and Gerontology–Geriatrics Research Laboratory, IRCCS “Casa Sollievo della Sofferenza”, Padre Pio da Pietrelcina Foundation, 71013, San Giovanni Rotondo, Foggia, Italy

    Davide Seripa, Giulia Paroni, Maria G. Matera, Carolina Gravina, Carlo Scarcelli, Michele Corritore, Luigi P. D’Ambrosio, Maria Urbano, Grazia D’Onofrio, Francesco Panza & Alberto Pilotto

  2. Unit of Biostatistics, IRCCS “Casa Sollievo della Sofferenza”, 71013, San Giovanni Rotondo, Foggia, Italy

    Massimiliano Copetti

  3. Dementia Research Group, Institute of Clinical Neurosciences, The John James Building, Frenchay Hospital, University of Bristol, Bristol, UK

    Patrick G. Kehoe

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  1. Davide Seripa
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  2. Giulia Paroni
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  3. Maria G. Matera
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  4. Carolina Gravina
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  13. Alberto Pilotto
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Correspondence to Alberto Pilotto.

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Seripa, D., Paroni, G., Matera, M.G. et al. Angiotensin-converting enzyme (ACE) genotypes and disability in hospitalized older patients. AGE 33, 409–419 (2011). https://doi.org/10.1007/s11357-010-9192-2

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