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Acute improvement of pulmonary hemodynamics does not alleviate Cheyne-Stokes respiration in chronic heart failure—a randomized, controlled, double-blind, crossover trial

  • Sleep Breathing Physiology and Disorders • Original Article
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Abstract

Objectives

This randomized, controlled trial aimed to investigate whether acute improvement of pulmonary congestion would reduce the severity of Cheyne-Stokes respiration (CSR) in patients with chronic heart failure (CHF).

Methods

Twenty-one consecutive patients with CHF and CSR (apnea-hypopnea index [AHI] ≥15/h) underwent right heart catheterization with titration of intravenous (IV) glyceryltrinitrate (GTN) to a maximum tolerable dosage and inhalation of iloprost 10 μg/mL after a washout phase. Maximum tolerable dosages of GTN and iloprost were randomly applied during full cardiorespiratory polysomnography within two split-night procedures and compared with IV or inhaled sodium chloride (NaCl) 0.9 %, respectively.

Results

GTN (6.2 ± 1.5 mg/h) and iloprost significantly lowered \mean pulmonary artery pressure (20.1 ± 9.0 to 11.6 ± 4.2 mmHg, p < 0.001 and 16.9 ± 7.9 to 14.2 ± 6.4 mmHg, p < 0.01, respectively). Pulmonary capillary wedge pressure was only reduced by GTN (14.0 ± 5.6 to 7.2 ± 3.9 mmHg, p < 0.001), and there was no significant change in the cardiac index. Sleep studies revealed no significant improvement in markers of CSR severity, including AHI, central apnea index, and CSR cycle length following GTN or iloprost treatment. Significant decreases in blood pressure, mean oxygen saturation, and S3 sleep were documented during GTN infusion.

Conclusions

Acute improvement of pulmonary congestion by GTN had no immediate impact on CSR severity. Future investigations must therefore include longer treatment periods and treatment regimens that have positive, rather than negative, additional effects on peripheral and central chemoreceptors and sleep structure.

Trial registration

German Clinical Trial Registry-ID:DRKS00000467 (www.germanctr.de)

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Acknowledgments

The authors would like to thank Markus Möllenberg, Jelena Dohrmann, Thomas Fischbach, Maryam Afsah, and all the nurses from our sleep laboratory for their enormous efforts spent on the success of this study.

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Authors and Affiliations

  1. Department of Cardiology, Heart and Diabetes Center North Rhine-Westphalia, Ruhr University Bochum, Georgstraße 11, 32545, Bad Oeynhausen, Germany

    Thomas Bitter, Henrik Fox, Heidi Schmalgemeier, Birgit Wellmann, Andrea Zwenke, Jens Spiesshöfer, Zisis Dimitriadis, Dieter Horstkotte & Olaf Oldenburg

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  1. Thomas Bitter
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  2. Henrik Fox
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  3. Heidi Schmalgemeier
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Correspondence to Thomas Bitter.

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Conflict of interest

The authors declare that they have no competing interests.

Funding

Bayer Healthcare GmbH and the Ruhr University Bochum provided financial support for the conduction of the study. The sponsor had no role in the design or conduct of this research.

Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

Informed consent

Informed consent was obtained from all individual participants included in the study.

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Bitter, T., Fox, H., Schmalgemeier, H. et al. Acute improvement of pulmonary hemodynamics does not alleviate Cheyne-Stokes respiration in chronic heart failure—a randomized, controlled, double-blind, crossover trial. Sleep Breath 20, 795–804 (2016). https://doi.org/10.1007/s11325-015-1300-1

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  • DOI: https://doi.org/10.1007/s11325-015-1300-1

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