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Decreased levels of serum nesfatin-1 in patients with obstructive sleep apnea syndrome

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Abstract

Purpose

Recent evidences suggest that inflammation is involved in the mechanism of obstructive sleep apnea syndrome (OSAS). Nesfatin-1, recently identified as the satiety regulator, is implicated to possess an anti-inflammatory effect. The aim of our study is to investigate whether serum levels of nesfatin-1 are associated with the presence and severity of OSAS.

Methods

A total of 196 patients with OSAS and 104 healthy subjects were enrolled in this study. Serum levels of nesfatin-1 were measured by enzyme-linked immunosorbent assay.

Results

OSAS patients showed significantly reduced levels of serum nesfatin-1 levels than healthy controls. Multivariable logistic regression analysis indicates that serum nesfatin-1 levels were inversely associated with the presence of OSAS (odds ration (OR) 0.003, 95 % confidence interval (CI) 0.001 to 0.017; P < 0.001). Serum levels of nesfatin-1 were significantly decreased in severe OSAS patients compared with mild and moderate OSAS patients. Spearman correlation analysis showed that serum nesfatin-1 levels were inversely correlated with the severity of OSAS. In addition, Spearman correlation analysis showed that serum nesfatin-1 levels were negatively correlated with body mass index (BMI) (r = −0.299, P < 0.001), waist–hip ratio (WHR) (r = −0.277, P < 0.001), homeostasis model assessment of insulin resistance (HOMA-IR) (r = −0.338, P < 0.001), and apnea–hypopnea index (AHI) (r = −0.248, P < 0.001) in patients with OSAS.

Conclusions

Decreased serum nesfatin-1 levels are associated with the presence and severity of OSAS.

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Source of funding

Science Funding of Tianjin First Center Hospital (SFTFCH120)

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Authors and Affiliations

  1. Department of Emergency Medicine, Tianjin First Center Hospital, 24 Fukang Road, Nankai District, 300192, Tianjin, People’s Republic of China

    Peng Shen & Yu Wang

  2. Department of Nephrology, Tianjin First Center Hospital, Tianjin, People’s Republic of China

    Yingying Han

  3. Department of Medical Politics, Affiliated Hospital of Logistics College of Chinese People’s Armed Police Force, Tianjin, People’s Republic of China

    Bo Cai

  4. Tianjin University of Traditional Chinese Medicine, 300193, Tianjin, China

    Peng Shen & Yingying Han

Authors
  1. Peng Shen
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  2. Yingying Han
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  3. Bo Cai
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  4. Yu Wang
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Corresponding author

Correspondence to Yu Wang.

Additional information

Peng Shen and Yingying Han contributed equally to this article

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Shen, P., Han, Y., Cai, B. et al. Decreased levels of serum nesfatin-1 in patients with obstructive sleep apnea syndrome. Sleep Breath 19, 515–522 (2015). https://doi.org/10.1007/s11325-014-1039-0

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  • DOI: https://doi.org/10.1007/s11325-014-1039-0

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