Functionalized Magnetonanoparticles in Visualization of Intracranial Tumors on MRI
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The development of nonradioactive and targeted magnetonanoparticles (MNP) capable of crossing the blood–brain barrier (BBB) and of concentrating in and enhancing the contrast of intracranial tumors on magnetic resonance imaging (MRI).
Nonradioactive 2-deoxy-d-glucose (2DG) was covalently attached to magnetonanoparticles composed of iron oxide and dextran and prepared for intravenous (tail) injection in the naïve rats and mouse models of glioma. MR images were acquired at 3 and 7 T.
2DG-MNP increased tumor visibility and improved delineation of tumor margins. Histopathology confirmed that 2DG-MNP crossed the BBB and accumulated within brain parenchyma.
Nonradioactive 2DG-MNP can cross an intact BBB on and improve visualization of tumor and tumor margins on MRI.
- Functionalized Magnetonanoparticles in Visualization of Intracranial Tumors on MRI
Molecular Imaging and Biology
Volume 15, Issue 3 , pp 299-306
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- 1. Jane and Terry Semel Institute for Neuroscience and Human Behavior, David Geffen school of Medicine, University of California, Los Angeles, CA, USA
- 5. Department of Radiology, David Geffen School of Medicine, University of California, Los Angeles, CA, USA
- 2. Department of Neurosurgery, David Geffen School of Medicine, University of California, Los Angeles, CA, USA
- 3. Department of Radiology, Children’s Hospital of Los Angeles, University of Southern California, Los Angeles, CA, USA
- 4. Department of Physics, University of California, Irvine, CA, USA