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Effects of dose rate on early and late complications in low dose rate brachytherapy for mobile tongue carcinoma using 192Ir sources

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Abstract

Objectives

Low dose rate brachytherapy using 192Ir sources (LDR-BRT) is the definitive radiotherapy for early stage mobile tongue carcinoma. The effects of dose rate on early and late complications require re-evaluation, because the prescribed dose is almost fixed and a spacer has recently been used in all cases. Given this situation, we investigated any adverse effects of dose rate in LDR-BRT.

Methods

For this retrospective study, 116 patients with early tongue cancer treated with LDR-BRT alone at Tokyo Medical and Dental University Medical Hospital between 2008 and 2013 were enrolled. The patients were classified into two groups according to dose rate or biological effective dose. All patients had a spacer in place throughout the treatment period.

Results

The rates of overall survival, local control, and neck node metastasis did not differ significantly between the two groups. Notably, there were no significant differences in the severity or incidence of early or late complications between the two groups.

Conclusions

In the present study, we demonstrated that a dose rate of up to 0.91 Gy/h did not significantly influence the incidence of early or late complications when other factors were well controlled in the presence of a spacer.

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Acknowledgements

This study was supported in part by JSPS KAKENHI Grant Number JP26293399.

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Authors and Affiliations

  1. Department of Oral Radiation Oncology, Division of Oral Health Science, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo, 113-8549, Japan

    Atsushi Kaida & Masahiko Miura

  2. Department of Oral and Maxillofacial Radiology, Division of Oral Health Science, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo, 113-8549, Japan

    Hiroshi Watanabe

  3. Department of Radiation Therapeutics and Oncology, Division of Maxillofacial and Neck Reconstruction, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo, 113-8549, Japan

    Kazuma Toda, Keiko Yuasa-Nakagawa & Ryoichi Yoshimura

Authors
  1. Atsushi Kaida
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  2. Hiroshi Watanabe
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  3. Kazuma Toda
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  4. Keiko Yuasa-Nakagawa
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  5. Ryoichi Yoshimura
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  6. Masahiko Miura
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Corresponding author

Correspondence to Masahiko Miura.

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Conflict of interest

Atsushi Kaida, Hiroshi Watanabe, Kazuma Toda, Keiko Yuasa-Nakagawa, Ryoichi Yoshimura, and Masahiko Miura declare that they have no conflict of interest.

Human rights statement

All procedures followed were in accordance with the ethical standards of the responsible committee on human experimentation (institutional and national) and with the Helsinki Declaration of 1964 and later versions.

Informed consent

Informed consent was obtained from all patients for being included in the study.

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Kaida, A., Watanabe, H., Toda, K. et al. Effects of dose rate on early and late complications in low dose rate brachytherapy for mobile tongue carcinoma using 192Ir sources. Oral Radiol 33, 187–192 (2017). https://doi.org/10.1007/s11282-016-0263-7

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  • DOI: https://doi.org/10.1007/s11282-016-0263-7

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