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Characterization of Colombian serotype 1 avian paramyxoviruses, 2008–2010

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Abstract

Newcastle disease (ND) still remains one of the most important diseases affecting domestic poultry in Colombia. Here, for the first time, we report on the molecular characterization of 12 virulent and 12 avirulent or lentogenic avian paramyxovirus type 1 (APMV-1) strains that were isolated from commercial, backyard, and game poultry in Colombia from 2008 to 2010. The 12 virulent isolates had a fusion (F) protein cleavage site with basic amino acids at positions 113, 115, and 116 and a phenylalanine at position 117 (112RRQKR*F117), characteristic of virulent strains. The remaining 12 isolates had the F protein cleavage sites 112GKQGR*L117 or 112GRQGR*L117 typical of avirulent or lentogenic APMV-1 strains. Phylogenetic analysis of full-length F genes of all isolates was performed, and based on the recently proposed criteria for classification of APMV-1 strains, the 24 Colombian isolates were found to belong to class II viruses and clustered into four different genotypes. Ten virulent isolates clustered with genotype VII (sub-genotype VIId), seven lentogenic strains within genotype II, five lentogenic strains with genotype I (sub-genotype Ia), and two virulent isolates within genotype XII. Our data provide essential information on the genetic diversity of AMPV-1 isolates circulating in Colombia.

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Acknowledgements

The authors would like to thank to Dr. Kurtis Swelka and his animal care staff for their help with the animal experiments. This study was part of a World Organization for Animal Health (OIE) sponsored twinning project between NCFAD, Winnipeg, and the Laboratorio Nacional de Diagnóstico Veterinario-ICA-Colombia.

Author contributions

Y. B. and J.P. provided laboratory management support and manuscript editing, T.H. amplified and sequenced the NDV isolates, W.X. performed the phylogenetic tree analysis, N.A.M.C. provided the virus isolates, H.K. amplified the NDV isolates, and C.P.C.P. coordinated the original characterization of NDV isolates in Colombia. All authors read and approved the final manuscript.

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Author notes

  1. J. Pasick

    Present address: , 174 Stone Road West, Guelph, ON, N1G 4S9, Canada

Authors and Affiliations

  1. National Centre for Foreign Animal Disease, Canadian Food Inspection Agency, Winnipeg, MB, Canada

    Y. Berhane, T. Hisanaga, W. Xu, H. Kehler & J. Pasick

  2. Department of Animal Science, University of Manitoba, Winnipeg, Canada

    Y. Berhane

  3. Instituto Colombiano Agropecuario, Bogotá, DC, Colombia

    N. A. Mosos Campos & C. P. Calderón Parra

Authors
  1. Y. Berhane
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  2. T. Hisanaga
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  3. W. Xu
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  4. N. A. Mosos Campos
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  5. H. Kehler
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  6. C. P. Calderón Parra
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  7. J. Pasick
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Corresponding author

Correspondence to J. Pasick.

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The authors declare no conflicts of interest.

Ethical approval

All experiments involving live vertebrates associated with this study were carried out in accordance with guidelines set out by the Canadian Council on Animal Care and approval by the institutional animal care committee.

Additional information

Edited by Zhen F. Fu.

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Berhane, Y., Hisanaga, T., Xu, W. et al. Characterization of Colombian serotype 1 avian paramyxoviruses, 2008–2010. Virus Genes 53, 584–592 (2017). https://doi.org/10.1007/s11262-017-1461-z

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  • DOI: https://doi.org/10.1007/s11262-017-1461-z

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