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A new gyrovirus in human feces

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Abstract

A novel gyrovirus genome found in the feces of an adult with diarrhea is described. The genome shows the three expected main ORFs encoding a structural protein (VP1), nonstructural protein (VP2), and Apoptin protein (VP3), which shared identities of 41, 42, and 38 % with those of the most closely related gyrovirus proteins, respectively. Given the high divergence in its genome, this gyrovirus may be considered the prototype for a new viral species (GyV9) in the Gyrovirus genus. Because the closest relatives of this gyrovirus infect chicken, a possible dietary origin for the presence of this virus in human feces is discussed.

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Acknowledgments

We acknowledge NHLBI Grant R01 HL105770 to E.L.D and the Blood Systems Research Institute for support. A.C.C. was supported by Sao Paulo Research Foundation (FAPESP), Grant Numbers 2014/05211-2 and 2012/03417-7. We thank Sylvie Pillet and Philippe Berthelot for collection of clinical information and samples.

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Authors and Affiliations

  1. Blood Systems Research Institute, San Francisco, CA, 94118, USA

    Tung Gia Phan, Antonio Charlys da Costa, Wen Zhang, Xutao Deng & Eric Delwart

  2. Department of Laboratory Medicine, University of California at San Francisco, San Francisco, CA, 94118, USA

    Tung Gia Phan & Eric Delwart

  3. Institute of Tropical Medicine, School of Medicine, University of São Paulo, São Paulo, Brazil

    Antonio Charlys da Costa

  4. School of Medicine, Jiangsu University, Zhenjiang, 212013, Jiangsu, China

    Wen Zhang

  5. National Reference Centre for Enteric Viruses, University Hospital of Dijon, Dijon, France

    Pierre Pothier & Katia Ambert-Balay

Authors
  1. Tung Gia Phan
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  2. Antonio Charlys da Costa
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Correspondence to Eric Delwart.

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Edited by Paul Schnitzler.

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Phan, T.G., da Costa, A.C., Zhang, W. et al. A new gyrovirus in human feces. Virus Genes 51, 132–135 (2015). https://doi.org/10.1007/s11262-015-1210-0

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  • DOI: https://doi.org/10.1007/s11262-015-1210-0

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