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Characterization of a new Puumala virus genotype associated with hemorrhagic fever with renal syndrome

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Abstract

Hantavirus serotype Puumala (PUUV) is the etiologic agent of Nephropathia epidemica (NE), a mild variant of Hemorrhagic Fever with Renal Syndrome (HFRS) in Europe, with lethality rates up to 1% among human patients. The serotype PUUV is composed of numerous geographically restricted strains forming a great number of phylogeographic lineages, sublineages, variants, and clusters. We describe a new, geographically and phylogenetically well-defined pathogenic PUUV sublineage in Southwest Germany (strain Heidelberg/hu) originated from an HFRS patient. The genetic analysis of PUUV strain Heidelberg/hu may contribute in future to better diagnostics, the development of vaccines, and the understanding of the factors that determine hantavirus pathogenesis.

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Authors and Affiliations

  1. Klinikum der Universität Heidelberg, Sektion Nephrologie Im Neuenheimer Feld 162, D-69120, Heidelberg, Federal Republic of Germany

    Udo Bahr, Martin Zeier & Walter Muranyi

Authors
  1. Udo Bahr
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  2. Martin Zeier
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  3. Walter Muranyi
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Corresponding author

Correspondence to Walter Muranyi.

Additional information

Note: Nucleotide sequence data reported are available in the GenBank database under the accession number DQ094844.

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Bahr, U., Zeier, M. & Muranyi, W. Characterization of a new Puumala virus genotype associated with hemorrhagic fever with renal syndrome. Virus Genes 33, 229–234 (2006). https://doi.org/10.1007/s11262-005-0061-5

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  • DOI: https://doi.org/10.1007/s11262-005-0061-5

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