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A pilot randomized study on use of oral acetazolamide in patients with refractory dysuria

  • Urology - Original Paper
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Abstract

Purpose

Assessment of daily oral acetazolamide in treatment of refractory dysuria.

Methods

Forty-one patients were randomly allocated to either be treated with acetazolamide (250 mg twice daily) or to receive placebo. The irritative voiding symptoms and urinary pH were recorded before and after treatment. The quality of life indices including the impact of voiding symptoms on daily and social activities, mood disturbance and sleep disorders were also measured by a questionnaire.

Results

Urinary pH was increased in the group taking acetazolamide (P < 0.001). They also reported alleviation of dysuria (P < 0.001), frequency (P = 0.039) and urgency (P = 0.016). However, nocturia was not improved in the study group. No change was observed in the aforementioned parameters in the placebo group. Daily personal life, social activities and the quality of sleep were improved by 52, 38 and 33%, respectively.

Conclusion

Oral acetazolamide can reduce the irritative voiding symptoms and improve the quality of life which is concomitant with an increase in urinary pH.

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Acknowledgements

Funding was received by Aja University of Medical Sciences.

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Authors and Affiliations

  1. Department of Urology, Imam Reza Hospital, Aja University of Medical Sciences, Tehran, Islamic Republic of Iran

    Morteza Hamidi & Ahmad Masoomi

  2. Department of Urology, Sina Hospital, Tehran University of Medical Sciences, Tehran, Islamic Republic of Iran

    Seyed Mohammad Kazem Aghamir & Alborz Salavati

Authors
  1. Morteza Hamidi
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  2. Seyed Mohammad Kazem Aghamir
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  3. Alborz Salavati
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  4. Ahmad Masoomi
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Corresponding author

Correspondence to Morteza Hamidi.

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Conflict of interest

Authors declare no conflict of interest.

Ethical approval

All procedures performed in this study were in accordance with the ethical standards of our institutional review board and with the 1964 Helsinki declaration and its later amendments.

Informed consent

Informed consent was obtained from all individual participants included in the study.

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Hamidi, M., Aghamir, S.M.K., Salavati, A. et al. A pilot randomized study on use of oral acetazolamide in patients with refractory dysuria. Int Urol Nephrol 49, 927–930 (2017). https://doi.org/10.1007/s11255-017-1566-2

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  • DOI: https://doi.org/10.1007/s11255-017-1566-2

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