Abstract
Aim of study
Urinary dysfunction in Creutzfeldt–Jakob disease (CJD) patients is attributed to functional incontinence, since they often have immobility and loss of motivation. In contrast, previously no urodynamic findings are available in CJD patients.
Case report
We had 2 CJD patients who had urinary frequency and urinary retention. We performed urodynamics with the spouse’s informed consent in order to explore the mechanism of urinary dysfunction in those cases. Case 1 had typical acute cognitive deterioration with incontinence and urinary retention, while case 2 had subacute cognitive deterioration (that started after admission) and nocturia. The urodynamic findings were diverse. One feature was detrusor overactivity during bladder filling in case 1. Another feature of urodynamic finding includes neurogenic change of sphincter EMG in case 1 and decreased bladder sensation in case 2.
Conclusion
Urodynamics in our two CJD patients revealed detrusor overactivity and neurogenic sphincter electromyogram, presumably reflecting pathological lesions in the prefrontal cortex/basal ganglia as well as the sacral spinal cord in CJD.
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We had no sponsors. None of the authors had conflict of interest to this study.
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All procedures performed in this study were in accordance with the ethical standards of the institutional committee and with the 1964 Helsinki Declaration, and performed with the family’s informed consent.
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Yano, M., Sakakibara, R., Tateno, F. et al. Urodynamic findings in patients with Creutzfeldt–Jakob disease: a case report. Int Urol Nephrol 48, 1579–1583 (2016). https://doi.org/10.1007/s11255-016-1344-6
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DOI: https://doi.org/10.1007/s11255-016-1344-6