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Basiliximab versus rabbit antithymocyte globulin as induction therapy for living-related renal transplantation: a single-center experience

  • Nephrology - Translational Section
  • Published:
International Urology and Nephrology Aims and scope Submit manuscript

A Correction to this article was published on 21 January 2019

This article has been updated

Abstract

Purpose

To compare the long-term effects of the interleukin-2 receptor antagonist basiliximab versus rabbit antithymocyte globulin as an induction therapy for living-related renal transplantation.

Methods

This is a prospective, open-label, nonrandomized, controlled study including 213 cases of renal transplant. Immunosuppressive therapy containing calcineurin inhibitors, mycophenolate mofetil and steroids was applied in all cases. The interleukin-2 receptor antagonist group (IL2Ra group) included 108 cases with 20 mg basiliximab induction on Day 0 and Day 4. The other 105 cases comprised the rabbit antithymocyte globulin group (rATG group) with 1.0 mg/kg/day ATG induction from Day 0 to Day 4. The primary endpoint was biopsy-proven acute rejection. Other endpoints included delayed graft function (DGF), graft loss and death.

Results

All patients were followed up for 3 years. Acute rejection rates in the IL2Ra group and the ATG group were 5.6 and 3.8 % (P = 0.781), and the differences in the DGF rates, graft loss and death were insignificant between groups. All-cause infection rates in the IL2Ra and rATG groups were 26.9 and 43.8 % (P = 0.010). Urinary tract infections were more common in the rATG group than in the IL2Ra group (15.2 vs 6.5 %, P = 0.040). Specific viral infection rates were significantly different (18.1 % in rATG group vs 8.3 % in IL2Ra group, P = 0.035).

Conclusions

IL2Ra and rATG had no significant differences as induction therapies during the perioperative period of living-related renal transplantation, according to acute rejection rates, DGF rates, graft loss, 1- and 3-year patient/graft survival rates. However, the incidence of infection, especially of urinary tract infection and specific viral infection, was higher in rATG-induced patients.

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Change history

  • 21 January 2019

    In the original publication, incorrect grant number was included in the Acknowledgements text as ?This study (article) was supported by Natural Science Foundation Y16H050011 of Zhejiang Province, China?. The correct acknowledgement section is given here.

  • 21 January 2019

    In the original publication, incorrect grant number was included in the Acknowledgements text as ���This study (article) was supported by Natural Science Foundation Y16H050011 of Zhejiang Province, China���. The correct acknowledgement section is given here.

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Acknowledgments

This study (article) was supported by Natural Science Foundation Y16H050011 of Zhejiang Province, China.

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    Authors and Affiliations

    1. Kidney Disease Center, The First Affiliated Hospital, College of Medicine, Zhejiang University, Qingchun Road 79, Hangzhou, 310003, China

      Hong-Feng Huang, Jing-Yi Zhou, Wen-Qing Xie, Jian-Yong Wu, Hao Deng & Jiang-Hua Chen

    2. Key Laboratory of Nephropathy, Hangzhou, 310003, Zhejiang Province, China

      Hong-Feng Huang, Jing-Yi Zhou, Wen-Qing Xie, Jian-Yong Wu, Hao Deng & Jiang-Hua Chen

    3. Kidney Disease Immunology Laboratory, The Third Grade Laboratory, State Administration of Traditional Chinese Medicine of China, Hangzhou, 310003, China

      Hong-Feng Huang, Jing-Yi Zhou, Wen-Qing Xie, Jian-Yong Wu, Hao Deng & Jiang-Hua Chen

    4. Key Laboratory of Multiple Organ Transplantation, Ministry of Health of China, Hangzhou, 310003, China

      Hong-Feng Huang, Jing-Yi Zhou, Wen-Qing Xie, Jian-Yong Wu, Hao Deng & Jiang-Hua Chen

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    1. Hong-Feng Huang
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    Correspondence to Jiang-Hua Chen.

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    No conflicts of interest to declare.

    Human and animal rights

    All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards, and all organs originate from living-related donors.

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    Informed consent was obtained from all individual participants included in the study.

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    Hong-Feng Huang and Jing-Yi Zhou have contributed equally to this work.

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    Huang, HF., Zhou, JY., Xie, WQ. et al. Basiliximab versus rabbit antithymocyte globulin as induction therapy for living-related renal transplantation: a single-center experience. Int Urol Nephrol 48, 1363–1370 (2016). https://doi.org/10.1007/s11255-016-1307-y

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    • DOI: https://doi.org/10.1007/s11255-016-1307-y

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