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Platelet-to-lymphocyte ratio predicts mortality better than neutrophil-to-lymphocyte ratio in hemodialysis patients

  • Nephrology - Original Paper
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Abstract

Purpose

Neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) were established showing the poor prognosis in some diseases, such as cardiovascular diseases and malignancies. The risk of mortality in patients with end-stage renal disease (ESRD) was higher than normal population. In this study, we aimed to investigate the relationship between NLR, PLR, and all-cause mortality in prevalent hemodialysis (HD) patients.

Methods

Eighty patients were enrolled in study. NLR and PLR obtained by dividing absolute neutrophil to absolute lymphocyte count and absolute platelet count to absolute lymphocyte count, respectively. The patients were followed prospectively for 24 months. The primary end point was all-cause mortality.

Results

Mean levels of neutrophil, lymphocyte, and platelet were 3904 ± 1543/mm3, 1442 ± 494/mm3, 174 ± 56 × 103/mm3, respectively. Twenty-one patients died before the follow-up at 24 months. Median NLR and PLR were 2.52 and 130.4, respectively. All-cause mortality was higher in patients with high NLR group compared to the patients with low NLR group (18.8 vs. 7.5 %, p = 0.031) and in patients with higher PLR group compared to patients with lower PLR group (18.8 vs. 7.5 %, p = 0.022). Following adjusted Cox regression analysis, the association of mortality and high NLR was lost (p = 0.54), but the significance of the association of high PLR and mortality increased (p = 0.013).

Conclusion

Although both NLR and PLR were associated with all-cause mortality in prevalent HD patients, only PLR could independently predict all-cause mortality in these populations.

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Acknowledgments

We thank the staff of our hemodialysis center and our patients for their help and support.

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Authors and Affiliations

  1. Division of Nephrology, Department of Internal Medicine, School of Medicine, Mustafa Kemal University, 31100, Antakya, Hatay, Turkey

    Mustafa Yaprak & Faruk Turgut

  2. Division of Nephrology, Department of Internal Medicine, School of Medicine, Harran University, Urfa, Turkey

    Mehmet Nuri Turan

  3. Department of Internal Medicine, Batman Regional State Hospital, Batman, Turkey

    Ramazan Dayanan

  4. Biochemistry, Batman Regional State Hospital, Batman, Turkey

    Selçuk Akın & Elif Değirmen

  5. Division of Medical Oncology, Batman Regional State Hospital, Batman, Turkey

    Mustafa Yıldırım

Authors
  1. Mustafa Yaprak
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  2. Mehmet Nuri Turan
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  4. Selçuk Akın
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  5. Elif Değirmen
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  6. Mustafa Yıldırım
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Correspondence to Mustafa Yaprak.

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The authors have no conflicts of interest to declare.

Ethics committee approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Declaration of Helsinki and its later amendments or comparable ethical standards.

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Written informed consent was obtained from all patients who participated in this study.

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Cite this article

Yaprak, M., Turan, M.N., Dayanan, R. et al. Platelet-to-lymphocyte ratio predicts mortality better than neutrophil-to-lymphocyte ratio in hemodialysis patients. Int Urol Nephrol 48, 1343–1348 (2016). https://doi.org/10.1007/s11255-016-1301-4

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  • DOI: https://doi.org/10.1007/s11255-016-1301-4

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