Abstract
Purpose
This study’s purpose was to examine established cardiovascular risk prediction model scores for their associations with albuminuria and estimated glomerular filtration rate (eGFR) in Korean population.
Methods
We calculated the 10-year atherosclerotic cardiovascular disease (ASCVD) risk estimated score, Korean coronary heart disease risk prediction score (KRS), and the Adult Treatment Panel (ATP) III risk score for 9733 South Koreans, aged 40–79 years, who were not diagnosed with stroke, angina pectoris, or myocardial ischemia using data from the 2011–2013 Korea National Health and Nutrition Examination Survey.
Results
The associations between cardiovascular risk model scores and the urine albumin-to-creatinine ratio (UACR) and eGFR tended to be stronger for the ASCVD risk score than for the other risk scores. The area under the receiver operating characteristic curve for increased albuminuria (UACR ≥ 30 mg/g) and decreased eGFR (<60 mL/min/1.73 m2) was significantly higher for the ASCVD risk score than for the ATP III risk score and the KRS (except for increased albuminuria in women).
Conclusions
The ASCVD risk score had a stronger relationship with and better predicted albuminuria and eGFR than did the KRS and ATP III risk score.
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K. Lee declares that she has no conflict of interest. J. Kim declares that he has no conflict of interest.
Ethical approval
All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards. The KNHANES was conducted with ethical approval from the Institutional Review Board of the Korea Center for Disease Control and Prevention (Nos: 2012-01EXP-01-2C, 2013-07CON-03-4C).
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Informed consent was obtained from all individual participants included in the study.
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Lee, K., Kim, J. Estimated glomerular filtration rate and albuminuria in Korean population evaluated for cardiovascular risk. Int Urol Nephrol 48, 759–764 (2016). https://doi.org/10.1007/s11255-016-1244-9
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DOI: https://doi.org/10.1007/s11255-016-1244-9