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The preventive effect of tamsulosin on voiding dysfunction after prostate biopsy: a prospective, open-label, observational study

  • Urology - Original Paper
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Abstract

Objectives

To evaluate the association of prostate biopsy with voiding impairment and to investigate whether tamsulosin treatment given before prostate biopsy could improve voiding dysfunction after the procedure.

Methods

The study included 88 consecutive patients who underwent transrectal ultrasound-guided prostate biopsy without prior BPH medication and were prospectively randomized. Of these 88 patients, 44 patients underwent prostate biopsy only without tamsulosin treatment and served as the control group. The remaining 44 patients were treated with tamsulosin (0.2 mg daily) beginning the day before the biopsy procedure for 7 days. The International Prostate Symptom Score (IPSS) was recorded in all patients before the procedure and on postbiopsy day 7. Maximal flow rate (Q max) and postvoid residual urine volume were recorded in all patients before the procedure and on postbiopsy days 1 and 7.

Results

No difference was found in baseline characteristics between the two groups. The IPSS (total, storage, and voiding symptom) was not significantly changed after biopsy in both groups. In the control group, the postvoid residual urine volume was increased on postbiopsy days 1 (P < 0.05) and 7, and the Q max was significantly decreased on postbiopsy day 7 compared with the baseline value (P < 0.05). In the tamsulosin group, Q max was significantly increased on postbiopsy days 1 and 7 (P < 0.01). The postvoid residual urine volume was not increased on postbiopsy days 1 and 7. Acute urinary retention after the biopsy procedure did not develop in any of the patients (0 %) in the tamsulosin group, but it developed in two patients (4.5 %) of the control group.

Conclusions

The results of our study show that prostate biopsy leads to objective voiding impairment. Therefore, the use of alpha-1 blocker tamsulosin before biopsy in patients without prior BPH medication may decrease this morbidity.

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Acknowledgments

This study was supported by a grant from Astellas Pharma Korea, Inc.

Conflict of interest

The authors declare that they have no conflict of interest.

Ethical standard

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional research committee. The institutional ethics committee approved this study, and all of the study participants read and signed an informed consent form.

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Authors and Affiliations

  1. Department of Urology, Chonnam National University Hwasun Hospital, 322 Seoyang-ro, Hwasun, 519-763, Republic of Korea

    Seung Jun Chung, Seung Il Jung, Ji Won Ryu, Eu Chang Hwang, Dong Deuk Kwon & Kwangsung Park

  2. Department of Radiology, Chonnam National University Hwasun Hospital, 322 Seoyang-ro, Hwasun, 519-763, Republic of Korea

    Jin Woong Kim

Authors
  1. Seung Jun Chung
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  2. Seung Il Jung
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  3. Ji Won Ryu
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  4. Eu Chang Hwang
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  5. Dong Deuk Kwon
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  6. Kwangsung Park
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  7. Jin Woong Kim
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Correspondence to Seung Il Jung.

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Chung, S.J., Jung, S.I., Ryu, J.W. et al. The preventive effect of tamsulosin on voiding dysfunction after prostate biopsy: a prospective, open-label, observational study. Int Urol Nephrol 47, 711–715 (2015). https://doi.org/10.1007/s11255-015-0955-7

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  • DOI: https://doi.org/10.1007/s11255-015-0955-7

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