Skip to main content
SpringerLink
Log in

Effect of intravaginal fluorogestone acetate sponges on prolactin levels of Damascus-local cross breed goats

  • Regular Articles
  • Published:
Tropical Animal Health and Production Aims and scope Submit manuscript

Abstract

The effect of intravaginal fluorogestone acetate (FGA) sponges on prolactin levels (PRL) and correlations between PRL and milk somatic cell count (SCC) and steroid hormones levels of Damascus-local cross goats during transitional period to anestrous were investigated in this study. Fifty-six goats were assigned to three groups. Group 1 (FGA, n = 19) was treated with 40 mg FGA and equine chorionic gonadotropin (600 IU, i.m.) at time of sponge withdrawal (day 0). Group 2 (FGA-PGF; n = 19) was treated similar to group 1 but was also injected with dinoprost tromethamine (naturally occurring PGF2α) (10 mg, i.m.) on day 0. Control goats (n = 18) were left untreated. On day 0, five fertile bucks were turned in with all goats. Milk and blood samples were collected on days −13 (day of sponge insertion), −6, 0, 1, 2, 7, 13, and 20. Prolactin levels were at lowest values on day −13 of the study and increased (p < 0.05) from day −6 to day 20 in all groups. A significant positive correlation (p < 0.05) between PRL and progesterone and between PRL and estradiol levels was found in this study. No significant correlation was found between PRL and SCC of all groups during the study except on days 2 and 20 where PRL levels were correlated (p < 0.05) with SCC of left udder halves of FGA group. In conclusion, estrus induction with FGA resulted in significant increase in PRL. A positive correlation was found between PRL and steroid hormones, but there was no correlation between PRL and goat milk SCC.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1

Similar content being viewed by others

References

  • Aleandri, M., Fagiolo, A., Calderini, P., Colafrancesco, G., Giangolini, G., Rosati, R., De Michelis, F., 1994. Studies conducted on somatic cells count of goat milk. International symposium on somatic cells and milk of small ruminants, Bella, Italy, pp. 55–58.

  • Bachelot, A., Carre, N., Mialon, O., Matelot, M., Servel, N., Monget, P., Ahtiainen, P., Huhtaniemi, I., Binart, N., 2013. The permissive role of prolactin as a regulator of luteinizing hormone action in the female mouse ovary and extragonadal tumorigenesis. American journal of physiology, endocrinology and metabolism, 305, E845-852.

    Article  CAS  Google Scholar 

  • Ben-Jonathan, N., Hnasko, R., 2001. Dopamine as a prolactin (PRL) inhibitor. Endocrinology Reviews, 22, 724–763.

    Article  CAS  Google Scholar 

  • Błaszczyk, B., Udała, J., Aczarzewicz, D.G., 2004. Changes in estradiol, progesterone, melatonin, prolactin and thyroxine concentrations in blood plasma of goats following induced estrus in and outside the natural breeding season. Small Ruminant Research, 51, 209–219.

    Article  Google Scholar 

  • Brownell, J., 1996. Quinagolide (Norprolac): a novel non-ergot prolactin inhibitor. Drugs Today (Barc) 32 (suppl B), 1–31.

  • Buttle, H. L., 1974. Seasonal variation of prolactin in plasma of male goats. Journal of Reproduction and Fertility, 37, 95–99.

    Article  CAS  PubMed  Google Scholar 

  • Currie, W., Gorewit, R., Michel, F., 1988. Endocrine changes, with special emphasis on oestradiol-17, prolactin and oxytocin, before and during labour and delivery in goats. Journal of Reproduction and Fertility, 82, 299–308.

    Article  CAS  PubMed  Google Scholar 

  • Embert, H.C., 1986. Veterinary Clinical Pathology. 4th ed. Saunders, Philadelphia.

    Google Scholar 

  • Flint, D., Gardner, M., 1994. Evidence that growth hormone stimulates milk synthesis by direct action on the mammary gland and that prolactin exerts effects on milk secretion by maintenance of mammary deoxyribonucleic acid content and tight junction status. Endocrinology, 135, 1119–1124.

    CAS  PubMed  Google Scholar 

  • Fragkou, I. A., Boscos, C. M., Fthenakis, G. C., 2014. Diagnosis of clinical or subclinical mastitis in ewes. Small Ruminant Research, 118:86–92.

    Article  Google Scholar 

  • Gaafar, K. M., Gabr, M. K., Teleb, D. F., 2005. The hormonal profile during the estrous cycle and gestation in Damascus goats. Small Ruminant Research, 57, 85–93.

    Article  Google Scholar 

  • Gomez-Brunet, A., Santiago-Moreno, J., del Campo, A., Malpaux, B., Chemineau, P., Tortonese, D. J., Gonzalez-Bulnes, A., Lopez-Sebastian, A., 2008. Endogenous circannual cycles of ovarian activity and changes in prolactin and melatonin secretion in wild and domestic female sheep maintained under a long-day photoperiod. Biology of Reproduction, 78, 552–562.

    Article  CAS  PubMed  Google Scholar 

  • Gregerson, K. A., 2006. Prolactin: structure, function, and regulation of secretion, In: Neill, JD (Ed.) Knobil and Neill’s Physiology of Reproduction. Elsevier Inc,, Amsterdam, pp. 1703–1726.

    Chapter  Google Scholar 

  • Hesselink, J. W., Taverne, M. A. M., Van Oord, H. A., 1995. Serum prolactin concentration in pseudopregnant and normally reproducing goats. The Veterinary record, August 12, 166–168

  • Kandiel, M. M. M., Watanabe, G., Sosa, G. A., Abou El-Roos, M. E. A., Abdel-Ghaffar, A. E., Li, J. Y., Manabe, N., El Azab, A. E. S. I., Taya, K., 2010. Profiles of Circulating Steroid Hormones, Gonadotropins, Immunoreactive Inhibin and Prolactin During Pregnancy in Goats and Immunolocalization of Inhibin Subunits, Steroidogenic Enzymes and Prolactin in the Corpus Luteum and Placenta. Journal of Reproduction and Development, 56, 243–250.

    Article  CAS  PubMed  Google Scholar 

  • Kowalewski, M. P., 2014. Luteal regression vs. prepartum luteolysis: Regulatory mechanisms governing canine corpus luteum function. Reproductive Biology, 14, 89–102

    Article  PubMed  Google Scholar 

  • Lacasse, P., Lollivier, V., Dessauge, F., Bruckmaier, R. M., Ollier, S., Boutinaud, M., 2012. New developments on the galactopoietic role of prolactin in dairy ruminants. Domestic Animal Endocrinology, 43, 154–160.

    Article  CAS  PubMed  Google Scholar 

  • Lamming, G. E., Moseley, S. R., McNeilly, J. R., 1974. Prolactin release in the sheep. Journal of Reproduction and Fertility, 40, 151–168.

    Article  CAS  PubMed  Google Scholar 

  • Lerondelle, C., Richard, Y., Issartial, J., 1992. Factors affecting somatic cell counts in goat milk. Small Ruminant Research, 8, 129–139.

    Article  Google Scholar 

  • McMahon, G., Shearman, R., Shutt, D. D., Smith, I., 1979. Prostaglandin F2a-Induced Prolactin Release and Luteolysis in the Goat. Australian Journal of Biological Sciences, 32, 109–114.

    CAS  PubMed  Google Scholar 

  • Mori, Y., Maeda, K., Sawasaki, T., Kano, Y., 1985. Photoperiodic control of prolactin secretion in the goats. Japanese Journal of Animal Reproduction, 31, 9–15.

    Article  CAS  Google Scholar 

  • Moro-Mendez, J., Hayes, J. F., 2005. Detection of QTL affecting mastitis resistance traits and SCS in Canadian holsteins. Journal of Dairy Science, 88, 201–201.

    Google Scholar 

  • Niswender, G. D., Juengel, J. L., Silva, P. J., Rollyson, M. K., McIntush, E. W., 2000. Mechanisms controlling the function and life span of the corpus luteum. Physiological reviews, 80, 1–29.

    CAS  PubMed  Google Scholar 

  • Paape, M. J., Wiggans, G. R., Bannerman, D. D., Thomas, D. L., Sanders, A. H., Contreras, A., Moroni, P., Miller, R. H., 2007. Monitoring goat and sheep milk somatic cell counts. Small Ruminant Research, 68, 114–125

    Article  Google Scholar 

  • Prandi, A., Romagnoli, G., Chiesa, F., Tamanini, C., 1987. Plasma prolactin variations and onset of ovarian activity in lactating anestrous goats given melatonin. Animal Reproduction Science, 13, 291–297.

    Article  CAS  Google Scholar 

  • Reeves, J. J., Arimura, A., Schally, A. V., 1970. Serum Levels of Prolactin and Luteinizing Hormone (LH) in the Ewe at Various Stages of the Estrous Cycle. Experimental Biology and Medicine, 134, 938–942.

    Article  CAS  Google Scholar 

  • Rhind, S. M., Chesworth, J. M., Robinson, J. J., 1978. A seasonal difference in ovine peripheral plasma prolactin and progesterone concentrations in early pregnancy and in the relationship between the two hormones. Journal of Reproduction and Fertility, 52, 79–81.

    Article  CAS  PubMed  Google Scholar 

  • Schams, D., Berisha, B., 2004. Regulation of Corpus Luteum Function in Cattle – an Overview. Reproduction in Domestic Animals, 39, 241–251

  • SPSS17.0, 2008. SPSS software (Version17.0), SPSS Inc., Chicago, IL, USA

  • Talafha, A. Q., Lafi, S. Q., Ababneh, M. M., 2008. The effect of estrus synchronization treatment on somatic cell count of transitional-anestrus local-Damascus cross breed goats’ milk. Tropical Animal Health and Production, 40, 185–192.

    Article  CAS  PubMed  Google Scholar 

  • Teleb, D. F., Gabr, M. K., Gaafar, K. M., 2003. Manipulation of lactation and suckling on the resumption of postpartum reproductive activity in Damascus goats. Small Ruminant Research, 49, 183–192.

    Article  Google Scholar 

  • Villaquiran, M., Gipson, T., Merkel, R., Goetsch, A., Sahlu, T., 2004. Body Condition Scores in Goats. American Institute for Goat Research, Langston University.

  • Wojdak-Maksymiec, K., Kemic, M., Strzalaka, J., 2008. Prolactin gene polymorphism and somatic cell count in dairy cattle. Journal of Animal and Veterinary Advances, 7, 35–40.

    CAS  Google Scholar 

Download references

Acknowledgments

The study reported herein received funding from the Deanship of Research, Jordan University of Science and Technology, Irbid, Jordan.

Conflict of interest

The authors declare that they have no conflict of interest

Author information

Authors and Affiliations

  1. Department of Veterinary Clinical Sciences, Faculty of Veterinary Medicine, Jordan University of Science and Technology, P.O. Box 3030, Irbid, 22110, Jordan

    Abdelsalam Qassem Talafha, Mohammed Mahmoud Ababneh & Ahmad Mahmoud Al-Majali

  2. Department of Basic Veterinary Sciences, Faculty of Veterinary Medicine, Jordan University of Science and Technology, Irbid, Jordan

    Mohammad Sobhi Khalifeh

Authors
  1. Abdelsalam Qassem Talafha
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Mohammed Mahmoud Ababneh
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Mohammad Sobhi Khalifeh
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Ahmad Mahmoud Al-Majali
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Abdelsalam Qassem Talafha.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Talafha, A.Q., Ababneh, M.M., Khalifeh, M.S. et al. Effect of intravaginal fluorogestone acetate sponges on prolactin levels of Damascus-local cross breed goats. Trop Anim Health Prod 47, 277–283 (2015). https://doi.org/10.1007/s11250-014-0716-0

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s11250-014-0716-0

Keywords

Search

Navigation