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Continuous Process for the Production of Hexafluoroisopropanol

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Abstract

There has been a renewed interest in the design of catalytic reactors to reduce transport limitations. Towards this goal, a novel single fluid-phase recirculating packed bed reactor concept has been developed and demonstrated for the hydrogenation of hexafluoroacetone to hexafluoroisopropanol, a precursor to Sevoflurane, used as an inhalation anesthetic, in the presence of a Ni/Al2O3 catalyst.

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Acknowledgments

The authors would like to sincerely thank Jim Burgoyne, Walt Megginson, Bill Crist, Ken Gelsinger, Mani Ganti, and Scott Kovalevich for providing help and support in setting up the continuous recirculating packed bed reactor and operating it safely. GC analyses of run samples were performed by William Zimkouski, Terrell Holmes, John Thomas, Ronald Hildreth, Keith Wilkins, Erik Perez, Lee Bashore, John Rogan, and Paul Messick. Their hard work, dedication, timeliness, and attention to details are much appreciated. Last, but not the least, the authors would like to express their deepest gratitude to Lloyd Abrams for catalyst characterization and Alex Marchione for 19F NMR analysis of HFA.

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Authors and Affiliations

  1. DuPont Company, Wilmington, DE, 19880, USA

    John J. Hagedorn, Gregory P. Shankwitz, Susanne H. Wolff, Stephen M. Tieri, James A. Schultz, Tiberiu M. Leib & Sourav K. Sengupta

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  1. John J. Hagedorn
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  2. Gregory P. Shankwitz
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  3. Susanne H. Wolff
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  4. Stephen M. Tieri
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  5. James A. Schultz
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  6. Tiberiu M. Leib
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  7. Sourav K. Sengupta
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Correspondence to Sourav K. Sengupta.

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Hagedorn, J.J., Shankwitz, G.P., Wolff, S.H. et al. Continuous Process for the Production of Hexafluoroisopropanol. Top Catal 57, 1385–1391 (2014). https://doi.org/10.1007/s11244-014-0309-1

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  • DOI: https://doi.org/10.1007/s11244-014-0309-1

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