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Retinal vein occlusion and paroxysmal nocturnal hemoglobinuria

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Abstract

Paroxysmal nocturnal hemoglobinuria (PNH) is a rare disorder associated with increased risk for thrombosis and reduced life expectancy. Retinal vein occlusion (RVO) is a frequent cause of vision loss but its relationship with PNH has not been studied systematically. Patients followed up for RVO in our ophthalmology department were screened for the presence of a PNH clone in peripheral blood by means of flow cytometry. The presence of other well-documented risk factors for RVO was also analyzed. In a series of 110 patients (54 males, median age of 67) we found no evidence of PNH. Most patients (97/110) had cardiovascular risk factors and/or hyperhomocysteinemia (67/110). Inherited thrombophilias were rare (three confirmed cases). Therefore, PNH does not appear to play a role in the development of RVO. However, this finding does not necessarily apply to young patients and/or those with no conventional risk factors for RVO, due to the low number of patients in these subgroups in our population.

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Authors and Affiliations

  1. Hematology Laboratory (Division of Thrombosis and Hemostasis), ICO-Badalona, Hospital Germans Trias i Pujol, Josep Carreras Leukemia Research Institute, Universitat Autonoma de Barcelona, Ctra. Canyet s/n, 08916, Badalona, Spain

    Marc Sorigue

  2. Hematology Laboratory, ICO-Badalona, Hospital Germans Trias i Pujol, Josep Carreras Leukemia Research Institute, Universitat Autonoma de Barcelona, Badalona, Spain

    Jordi Juncà, Elisa Orna, Ines Rodríguez-Hernandez & Evarist Feliu

  3. Department of Ophthalmology, Hospital Germans Trias i Pujol, Universitat Autonoma de Barcelona, Badalona, Spain

    Nevena Romanic, Jordi Castellvi, Montse Soler & Susana Ruiz

  4. Department of Hematology, Hospital Germans Trias i Pujol, Universitat Autonoma de Barcelona, Badalona, Spain

    Edurne Sarrate

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  1. Marc Sorigue
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  2. Jordi Juncà
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  3. Elisa Orna
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Correspondence to Marc Sorigue.

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Alexion Barcelona provided FLAER.

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Sorigue, M., Juncà, J., Orna, E. et al. Retinal vein occlusion and paroxysmal nocturnal hemoglobinuria. J Thromb Thrombolysis 44, 63–66 (2017). https://doi.org/10.1007/s11239-017-1502-4

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  • DOI: https://doi.org/10.1007/s11239-017-1502-4

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