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ABO blood group in primary antiphospholipid syndrome: influence in the site of thrombosis?

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Abstract

Antiphospholipid syndrome (APS) is characterized by vascular thrombosis and/or obstetric complications associated with presence of antiphospholipid antibodies (aPL) but additional factors would also induce thrombosis. ABO (H) blood groups are known to be closely related to thrombosis, especially non-O blood type with venous events. The aim of this study was to investigate possible role of ABO (H) blood types in the thrombotic events in primary APS (PAPS). Seventy PAPS patients were selected for the study and were divided according to ABO blood group in: O PAPS (n = 26) and non-O PAPS (n = 44). ABO blood group phenotyping was performed by indirect technique. aPL anticardiolipin (aCL) and anti-βeta2 glycoprotein-1 (aβ2GPI) and the concentrations and activities of von Willebrand factor (VWF) were measured with ELISA. Lupus anticoagulant (LA) was detected by coagulation assays. A significant higher frequency of venous events was observed in non-O PAPS group (72.7 vs. 46.2 %, p = 0.040). In contrast, the frequency of arterial events was significantly higher in the O PAPS compared to the non-O PAPS group (69.2 vs. 36.4 %, respectively; p = 0.013). Frequencies of aCL, LA, aβ2GPI and triple aPL positivity were similar in both groups (p > 0.05). VWF antigen (75.54 ± 8.68 vs. 79.51 ± 7.07 IU/dl, p = 0.041) and activity (70.23 ± 11.96 vs. 77.92 ± 13.67 %, p = 0.020) were decreased in O PAPS compared to non-O blood group. VWF:CB/VWF:Ag ratio was similar among groups (p > 0.05). This is the first report that confirms the role of ABO blood system in thrombosis of PAPS and suggests that non-O blood group was related with venous events and O blood group with arterial thrombosis.

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Acknowledgments

This study was supported by the Conselho Nacional de Desenvolvimento Científico e Tecnológico, CNPq Grants 479161-2012-7 (SPB), 301411/2009-3 (EB), and 306963/2011-6 (EFB), the Fundação de Amparo a Pesquisa do Estado de São Paulo FAPESP, Grant 2013/02785-5 (RPSS), the Federico Foundation (EB and EFB), and the Instituto Nacional de Ciência e Tecnologia de Fluídos Complexos (SPB).

Conflicts of interest

The authors declare that they have no conflict of interest.

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Authors and Affiliations

  1. Laboratory of Genetics and Molecular Hematology (LIM 31), School of Medicine, University of São Paulo (USP), Av. Dr. Enéas de Carvalho Aguiar, 155, 1° andar, sala 43, São Paulo, SP, 05403-000, Brazil

    Natália Mastantuono Nascimento & Sergio Paulo Bydlowski

  2. Fundação Pró-Sangue Hemocentro de São Paulo, Av. Dr. Enéas de Carvalho Aguiar, 155, 1° andar, São Paulo, SP, 05403-000, Brazil

    Rosangela Paula Silva Soares

  3. Rheumatology Division, School of Medicine, University of São Paulo (USP), Av. Dr. Arnaldo 455, 3° andar, sala 3190, São Paulo, SP, 01246-903, Brazil

    Danieli Castro Oliveira de Andrade, Eloísa Bonfá, Luciana Parente Costa Seguro & Eduardo Ferreira Borba

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  1. Natália Mastantuono Nascimento
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  2. Sergio Paulo Bydlowski
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  3. Rosangela Paula Silva Soares
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Correspondence to Sergio Paulo Bydlowski.

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Nascimento, N.M., Bydlowski, S.P., Soares, R.P.S. et al. ABO blood group in primary antiphospholipid syndrome: influence in the site of thrombosis?. J Thromb Thrombolysis 40, 374–378 (2015). https://doi.org/10.1007/s11239-015-1176-8

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  • DOI: https://doi.org/10.1007/s11239-015-1176-8

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